Mark Andermann

Rachel Essner and the team deserve huge congrats for this opus on integrative brain-to-body signaling in the parabrachial nucleus. Now improved and published! Check it out.

Imaging activity in many defined cell types is now easi(er) using conventional 2p and confocal microscopes. 3000-5000 imaged neurons per recording, 78% matched to post hoc 3D EASI-FISH. We wanted this to be useful, affordable, and reliable. Jonna and an incredible team made it happen. Check it out!

Peter Kalugin's paper on optical tracking of up to ten neuromodulators simultaneously is out in Neuron with some cool new results, including quantitative demixing of norepinephrine and dopamine concentrations. Please check it out!

Excited to share my PhD paper! In it, we use targeted 2-photon optogenetic stimulation to determine how V1 activity is read-out in a detection task. We found that network influence, not visual coding properties, predicted the impact of ensembles on behavior - contradicting our expectations (1/5).

Our lab is hoping to hire a long-term lab manager / research associate to help with admin tasks and neuroscience experiments (3-year minimum commitment). bilh.wd1.myworkdayjobs.com/External/job...

Congrats Marta on a very strong effort!

NEW: Mark Andermann ( @markandermann.bsky.social)‬ of @harvardmed.bsky.social‬ brings experimental data and computational modeling together to understand cortical reactivations. Watch the video: youtu.be/1N6i7Zi9kXs #NeuroAI2025 #neuroscience #AI #NeuroAI

Out now in @nathumbehav.nature.com: Cuts to NIH funding will impact the economy and employment nationwide. We visualize these losses and advocate for a theory-driven approach to communicating local, self-relevant impact. w/ @joshuasweitz.bsky.social + SCIMaP team: www.nature.com/articles/s41...

Wild! Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.

Disruption of visual cortical activity and offline reactivations of recent salient experience in the hours following training on a task associating cues with outcomes completely blocks across-day learning! Exciting work by Kristian, Marianne and their team!

We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet. Congrats to Marta, Stephen and the whole team!

Academic workers across the country are calling 📞 Legislators to ask them to sign on to bipartisan letters ✉️ in support of robust NIH funding and opposing the 15% indirect cost caps. Take 5 minutes to call your legislators today. Deadline is May 19th. docs.google.com/document/d/1...

A drop of milkshake takes a wild ride as it passes through the body. Rachel and Kiersten and the team came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.

🚨iGluSnFR4 is finally out!🚨🧪 We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️ www.biorxiv.org/content/10.1... 🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX #Neuroscience

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

Don't miss the final opportunity to showcase your research with a poster presentation at Interoception at the @alleninstitute.bsky.social! Submit by March 4 (11:59pm MST). keysym.us/KSInterocept... youtu.be/424TJ_VTUCI #KSInteroception25 @markandermann.bsky.social @ruimcosta.bsky.social

Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping. www.eventbrite.com/e/stand-up-f...

We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!

Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution https://www.biorxiv.org/content/10.1101/2025.01.10.632162v1

Eight days left to submit your abstract for the 2025 Keystone Symposium on Brain Body Communication at the Allen Institute for Brain Science in Seattle! Join us in exploring the latest in interoception research. Please repost, thanks!

Happy holidays! For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!

The choroid plexus actively recruits immune cells during inflammation, according to a new study. By @claudia-lopez.bsky.social www.thetransmitter.org/neuroinflamm...

Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3

Come explore emerging research in brain-body communication @KeystoneSymp Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh