Mark Plitt

Mark Plitt

@markplitt.bsky.social

Postdoc @ UC Berkeley | Jane Coffin Childs Fellow | brains, memory, synapses | new(ish) dad | lover of all animal facts

111 followers116 following3 posts

Mark Plitt
@markplitt.bsky.social

Very exciting to see our work being highlighted by @thetransmitter.bsky.social! Thanks to Natalia Mesa, and as always thanks to our collaborators in the Jayaraman lab!… back to grinding away at reviewer experiments

Yvette Fisher@yvetteefisher.bsky.social

Thank you Natalia Mesa at the @thetransmitter.bsky.social for highlighting our labs preprint on synaptic mechanisms of head direction learning!! 🪰🧭 Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab! www.thetransmitter.org/learning-and...

thetransmitter.orgUnique learning mechanism drives navigation in fruit fliesThe neuromodulator octopamine, the insect counterpart to norepinephrine, helps flies get their bearings in an unfamiliar environment.
Mark Plitt
@markplitt.bsky.social

My final paper from grad school is out! Thank you to @marisosa.bsky.social @ellasay.bsky.social and my co-first author Konstantin Kaganovsky! We show that reward and novelty coding in the hippocampus requires a specific membrane fusion protein implicated in activity-dependent AMPAR mobilization!

Lisa Giocomo@lgiocomo.bsky.social

New paper! Congrats to @markplitt.bsky.social, Konstantin and team! The brain’s spatial map isn’t static but for hippocampus CA1 maps to change with experience, they need postsynaptic membrane fusion. A new link between synaptic machinery and flexible coding! www.sciencedirect.com/science/arti...

sciencedirect.comHippocampal place code plasticity in CA1 requires postsynaptic membrane fusionRapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a central component of synaptic plasticity. However, it is un…

Mark Plitt reposted

Emily A. Aery Jones
@emilyaeryjones.bsky.social

My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13

nature.comEntorhinal cortex represents task-relevant remote locations independently of CA1 - Nature NeuroscienceNeurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...
Mark Plitt
@markplitt.bsky.social

I am incredibly excited and proud to share my first preprint from my postdoc! Thank you to all of the co-authors for all your hard work! Check out the paper for big insights into plasticity mechanisms in navigation circuits! And surprising motifs for inhibitory synaptic plasticity!

Yvette Fisher@yvetteefisher.bsky.social

*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️

Mark Plitt reposted

Mari Sosa
@marisosa.bsky.social

It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵 www.nature.com/articles/s41...

nature.comA flexible hippocampal population code for experience relative to reward - Nature NeuroscienceSosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...

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