Mary Mirvis

1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions? @wallaceucsf.bsky.social www.biorxiv.org/content/10.6...

Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it. PhD students: choose someone you like to talk to!

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

fascinating new preprint!!

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

I'll be sharing my work on how cells know when to make missing structures at #cellbio2025 today! Come check out my poster (B406) and my talk in the Evolutionary Cell Bio mini symposium session which starts at 4pm.

The giant ciliate Stentor has a macronucleus that undergoes a dramatic shape change during cellular regeneration. In poster 038 at CellBio2025 Monday Dec 8, I present work by Isabella Ibalio showing that histone modifications correlate with these dramatic nuclear shape changes.

Stentor is a single cell that can regenerate missing pieces, but how does it know when something is missing? In poster 406 at CellBio2025 Monday Dec 8, Connie Yan shows that conserved cell cycle machinery plays a key role in triggering cellular regeneration.

Stentor is a single cell with a complex cortical pattern showing anterior/posterior polarization In poster 410 at CellBio2025 Monday Dec 8, Yina Hudnall shows a role for posterior-enriched mRNA that encoding DNA binding proteins.

Mitochondria form dynamic networks that can be represented as graphs. But the space of graphs is complex. In poster 376 at CellBio2025 Monday Dec 8, Raphie Mostov presents a mathematical approach to represent mitochondria far more simply.

Come check out my poster & talk!! #CellBio2025 #ASCB

The cell is a crowded place where organelles are packed together . In poster B365 at CellBio2025 Monday Dec 8 in the Quantitative Modeling session room 122, Mary Mirvis uses soft x-ray tomography to explore how packing interactions affect organelle shape and interaction.

The low Reynolds number of cytoplasmic flow which makes mixing hard. In poster 359 at the CellBio2025 meeting Sunday Dec 7, Ulises Diaz shows how giant cells leverage reversible actin gel assembly to drive rapid mixing of cytoplasm, faster even than "chaotic mixing" schemes.

Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 163 at CellBio2025 Sunday Dec 7, I present work by Hiro Ishikawa using a synthetic biology approach to test a length-sensing model based on diffusion of kinesin in flagella

Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.

Cells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.

#newpost, exploring an exciting meta-science movement called #nightscience! Thanks @marymirvis.bsky.social for the resource!

Your go-to tutorial for simulating mesoscale membranes is here. Look no further for: -Understanding the state of the field -A guide for creating new models for your science -Hands-on tutorials to simulate your very own membranes See tinyurl.com/punk3tcu and the below 🧵 start your journey 💻

In another exciting development our new preprint is online: www.biorxiv.org/cgi/content/... This is the work of my brilliant graduate student Katerina Kourkoulou in collaboration with Maggie Liu and Arnold Mathijssen. Here is a video of the subject of our study:

Metascience 2025 recordings are now available! #Metascience25 gathered researchers, funders, policymakers & more to explore how the research process can improve. The program included preconference symposia & plenary sessions on topics from policy change to AI in research. 🎥 cassyni.com/s/metasc...

📢 Abstract submission deadline reminder for 'Cell biology of the nucleus'! Before packing your bags and leaving for your summer vacation, there is one important task left to do: submit your abstract for #EESNucleus ✍️ Deadline is 26 August: https://s.embl.org/ees25-07-bl

So excited to be in Heidelberg for www.embl.org/about/info/c... ! This is going to be an awesome meeting, been looking forward to it for months! #EESTCBio

Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration. www.ascb.org/society-news...

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

I’ll be there! Can’t wait!

Losing MOSAIC is such a senseless gut punch to so many deserving people like my lab mate @aralbright.bsky.social and science as a whole. www.npr.org/sections/sho...

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!

Come to the Annual Fletcher Lab Artshow on Friday May 9th, 2025! We host this event yearly as an opportunity for folks to display their artwork, come together with wine and cheese, and admire artwork!

Many thanks to my co-author Brooke Weingard, my advisors Steve Goodman & @wallaceucsf.bsky.social , my Marshall lab mates and many others who have been supportive of this sort of oddball project. Now more than ever, I'm humbled by the absolute privilege of doing science! thanks for reading! 11/11

I'm excited for this chance to highlight the power of rigorous evidence synthesis for fundamental cell biology, something I hope to see more of and help develop in the future! If you're interested in the intersection of evidence/knowledge synthesis & fundamental bio please connect with me! 10/11

Stay tuned for part two of this story which will dive into the linguistic and conceptual basis of "cell anatomy" throughout the corpus. We plan on keeping this corpus up to date & expanding its scope as a collaborative interactive resource (we call it a "living corpus" as a running joke ) 9/11

We believe that the acceleration of whole-cell imaging tech & data in recent years represents the early stages of an emerging field. Hopefully this work will serve as a useful tool and catalyst for community discourse to standardize technical & conceptual norms. 8/11

But there are biases in the dataset! Namely small sample sizes, small cell types, non-mammalian cell types. This is a reflection of how technically challenging and costly whole-cell data is, even further highlighting the value of pooling datasets for research synthesis work. 7/11