Molecular and Cellular Function, University of Manchester

Molecular and Cellular Function, University of Manchester

@mcf-uom.bsky.social

We are the Division of Molecular and Cellular Function Division at the Faculty of Biology, Medicine and Health, University of Manchester. We perform discovery research to provide insight into crucial cellular processes.

195 followers38 following16 posts

Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

New preprint from MCF: Kerrie Marie and collaborators reveal dynamic patterns of lineage state switching correlated with melanoma tumor evolution, offering insights into potential new therapeutic targets. www.biorxiv.org/content/10.1...

biorxiv.orgTransitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasisMelanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of ...

Molecular and Cellular Function, University of Manchester reposted

Byron Lab
@thebyronlab.bsky.social

Fantastic postdoc opportunities available @fbmh-uom.bsky.social! 💡 Please get in touch if you're interested in using biomaterials, cell biology, 'omics technologies and data science to investigate cell adhesion networks and gene expression in cancer #science #research #jobs #careers

Molecular and Cellular Function, University of Manchester@mcf-uom.bsky.social

Early-career fellowships at the University of Manchester! To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers: www.bmh.manchester.ac.uk/research/sup...

bmh.manchester.ac.ukBicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of ManchesterFind out about and apply for a Bicentenary Early Career Research Fellowship.
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

Our researchers leb by @hilaryashe.bsky.social show the versatility of the SunTag system by providing proof-of-principle data for new avenues of exploration, quantitation and visualisation of protein synthesis. @biologists.bsky.social journals.biologists.com/jcs/article/...

journals.biologists.comExploiting the SunTag system to study the developmental regulation of mRNA translationThe ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of transl...

Molecular and Cellular Function, University of Manchester reposted

Hilary Ashe
@hilaryashe.bsky.social

Our new paper describes how SunTag imaging of mRNA translation can be used to study ribosome pausing in development. We also adapt the system to study translation of a secreted protein. Work done in collaboration with @mrattray.bsky.social and @markashe.bsky.social doi.org/10.1242/jcs....

doi.orgExploiting the SunTag system to study the developmental regulation of mRNA translationThe ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of transl...
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

A new day, a new preprint! @tranejoan.bsky.social lab demonstrated that macrophages promote collagen deposition in fibroblasts by inducing circadian rhythms, with M2-derived PDGFA playing a key role in this process. Read here: www.biorxiv.org/content/10.1...

biorxiv.orgMacrophages promote collagen deposition through circadian regulation of fibroblastsCollagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Molecular and Cellular Function, University of Manchester reposted

Joan Chang
@tranejoan.bsky.social

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻 #macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social www.biorxiv.org/content/10.1...

biorxiv.orgMacrophages promote collagen deposition through circadian regulation of fibroblastsCollagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Molecular and Cellular Function, University of Manchester reposted

Sankari Nagarajan
@sankarinagarajan.bsky.social

Exciting PhD opportunity available in my lab for the students from Black heritage background. Apply soon. 🤞🤞🤞 @mcr-breastcentre.bsky.social @mcf-uom.bsky.social CRUK Black Leaders in Cancer Non-Clinical PhD Opportunity 📅 Deadline: 4 April 🔗 crukcentre.manchester.ac.uk/study/resear...

crukcentre.manchester.ac.ukResearch Opportunities - Cancer Research UK Manchester CentreExplore the range of postgraduate cancer research opportunities available in Manchester.
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

Early-career fellowships at the University of Manchester! To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers: www.bmh.manchester.ac.uk/research/sup...

bmh.manchester.ac.ukBicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of ManchesterFind out about and apply for a Bicentenary Early Career Research Fellowship.
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

New preprint! @sankarinagarajan.bsky.social and colleagues employed machine learning approaches to identify critical gene pathways and transcription factor networks in breast cancer

Sankari Nagarajan@sankarinagarajan.bsky.social

Our lab's very first manuscript is out in BioRxiv. Hope this would be interesting for breast cancer scientists: www.biorxiv.org/content/10.1... @mcf-uom.bsky.social @mcr-breastcentre.bsky.social @mcrcnews.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

biorxiv.orgSubtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancersGene expression is tightly controlled by DNA elements called enhancers by associating with lineage-specific transcription factors. These enhancers transcribe non-coding RNAs (called enhancer RNAs or e...

Molecular and Cellular Function, University of Manchester reposted

Hilary Ashe
@hilaryashe.bsky.social

Is there more to defining the eve stripes in the Drosophila embryo than just transcriptional regulation? We provide evidence that spatially regulated mRNA decay is also important.

Magnus Rattray@mrattray.bsky.social

Nice new paper from Jennifer Love and @hilaryashe.bsky.social lab members shows how mRNA decay is spatially and temporally regulated, ramping up at the edges of stripes in early drosophila embryos, with mRNAs increasingly localising to P-bodies for degradation www.biorxiv.org/content/10.1...

biorxiv.orgbiorxiv.org
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

New paper by @pliotasgroup.bsky.social !

Pliotas Group@pliotasgroup.bsky.social

In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...

cell.comThe mechanosensitive channel YbiO has a conductance equivalent to the largest gated-poreLane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

Paper alert! Pliotas Group reviewed pulsed dipolar electron paramagnetic resonance spectroscopy applications and highlighted emerging strategies for future studies www.sciencedirect.com/science/arti...

sciencedirect.comEnabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labellingPulsed dipolar electron paramagnetic resonance spectroscopy (PDS), combined with site-directed spin-labelling, represents a powerful tool for the inve…

Molecular and Cellular Function, University of Manchester reposted

Joan Chang
@tranejoan.bsky.social

Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻 Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis. doi.org/10.7554/eLif... @elife.bsky.social

doi.orgEndocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosisSecretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

Paper alert! A collaborative study led by @tranejoan.bsky.social shows that circadian-regulated endocytic recycling is central to homeostatic assembly of collagen fibrils and is disrupted in diseases. Published in @elife.bsky.social doi.org/10.7554/eLif...

doi.orgEndocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosisSecretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...
Molecular and Cellular Function, University of Manchester
@mcf-uom.bsky.social

Bicentenary PhD scholarship is available in @ximenasotouom.bsky.social group. If you are enthusiastic and keen on using Zebrafish to elucidate signals and mechanisms involved in spinal cord regeneration apply! Deadline is the 10th of January, 2025. www.findaphd.com/phds/project...

findaphd.com(Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression at The University of Manchester on FindAPhD.comPhD Project - (Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression at The University of Manchester, listed on FindAPhD.com

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