Jason McLellan
Jason McLellan
@mclellanlab.bsky.social
Structural virology / Structure-based vaccine design mclellanlab.org Professor of Molecular Biosciences The University of Texas at Austin Opinions are my own and not the views of my employer
3.7K followers204 following512 posts
Always nice to see some of our work featured in the PDB's Molecule of the Month: pdb101.rcsb.org/motm/319
I enjoyed this article. Interesting statistical comparisons. www.expectinggoals.com/p/messi-rona...
My daughter was invited on stage to help Neil deGrasse Tyson @neildegrassetyson.com post a Tweet!
Jason McLellan reposted
#PostdocRecruiting: My group at the University of Texas at Austin is recruiting a Postdoc in virology and structural biology. Please see more details here: utaustin.wd1.myworkdayjobs.com/UTstaff/job/... Informal inquiries are encouraged, and see more lab info here: zunlongke-lab.org
Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
In addition, we imaged rVSVs displaying ANDV and CCHFV glycoproteins (provided by @chandranlab.bsky.social) and worked with @jesseerasmus.bsky.social and colleagues at HDT Bio to assess the VLPs' immunogenicity in mice via repRNA. Thanks to all authors for their contributions!
The published paper is now available online: authors.elsevier.com/sd/article/S...
Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
Excited for Adam Klivans and my other colleagues at UT working in the AI space!
Already among the most powerful artificial intelligence hubs in academia, the UT Center for Generative AI is keeping its foot on the gas. “It’s exciting to accelerate discovery and to create more opportunities for our researchers to push the boundaries of what’s possible.”
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
UT Austin has a new “genius grant” recipient! Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation. #TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social cns.utexas.edu/news/accolad...
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
In addition, 7/8 antibodies targeting MPXV cross-reacted with VARV (smallpox) OPG153. We mapped 3 epitopes on OPG153 by cryo-EM and showed that immunization with the globular domain of OPG153 can elicit significantly higher nAb titers than MVA-BN against VACV and MPXV. doi.org/10.1101/2025....
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
Jason McLellan reposted
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
Jason McLellan reposted
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV. @mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine cns.utexas.edu/news/announc...
Jason McLellan reposted
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
Promising results for a third PreF-based RSV vaccine: https://www.nejm.org/doi/10.1056/NEJMoa2307079
My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286
My babies are the October Molecule of the Month https://pdb101.rcsb.org/motm/286
Positive Phase I results for @icosavax's bivalent RSV/HMPV vaccine candidate displaying prefusion F-based antigens on their protein nanoparticles https://ir.icosavax.com/news-releases/news-release-details/icosavax-announces-positive-topline-interim-phase-1-results