STITCHES Medicine - the Best of Medical Research

Every day we'll send you quick, insightful updates on medicine, carefully selected from top journals and the best papers, in a daily 5-minute read. #MedSky #newsletter Subscribe for free! 👇

Single-dose Lonvoguran Ziclumeran slashes hereditary angioedema attack rates by 87% compared to placebo in pivotal trial. by Cohn DM, Gurugama P (...) Banerji A et 19 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2600931

FBXW5 suppresses immune response in triple-negative breast cancer, promoting resistance to chemoimmunotherapy; targeting it may enhance treatment efficacy. by Li X, Chen T (...) Yang Q et 16 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/201573

Continuous glucose monitoring significantly reduces A1C levels and hyperglycemia risk in non-insulin-treated type 2 diabetes patients. by Oser TK, Martens T (...) Beck RW et 25 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2608571

AI-enabled epilepsy management system enhances patient engagement and seizure detection accuracy through real-time feedback and monitoring. by Goldblum Z, Shi H (...) Litt B et 14 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Multicancer early-detection tests show no significant impact on late-stage cancer diagnosis, warranting further long-term investigation. by Sasieni P, Johnson P (...) Swanton C et 10 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2505723

Urine cfRNA profiling accurately detects bladder cancer and predicts treatment responses, offering a novel, noninvasive diagnostic avenue. by Liu KJ, Shi WY (...) Diehn M et 39 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Refined CIRI2-CLL Enhances Risk Prediction for CLL Patients, Boosting Progression-Free Survival Forecasts by 14%-37% After Treatment by Al-Sawaf O, Zhang C (...) Fischer K et 19 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-26-00161

Ovarian Cancer Guideline Update: Prioritize Platinum-Based Regimens for Recurrence, with Mirvetuximab for Resistant Cases by Lesnock JL, Temin S (...) Scalici JM et 14 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-26-01591

Perinatal immune plasticity enables infants to transition from maternal reliance to independence, influencing immunity and infection responses significantly. by Kierdorf K, Sperandio M, Hornef MW and Henneke P in Nat Rev Immunol #MedSky 👉 get more here 📖 read the article:

Targeting tryptophan hydroxylase 1 halts aggressive neuroendocrine prostate cancer growth and disrupts its plasticity, revealing a new therapeutic avenue. by Wei J, Wang J (...) Wu BJ et 9 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/200391

CCND1 Boosts Cardiac Repair by Reprogramming Macrophages Post-Myocardial Infarction, Targeting a Novel Therapeutic Axis. by Wang C, Han H (...) Chen Q et 20 al. in Circulation #MedSky 👉 get more here 📖 read the article: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079966

Oveporexton dramatically enhances wakefulness and significantly reduces cataplexy in narcolepsy type 1, despite notable side effects. by Dauvilliers Y, Mignot E (...) Plazzi G et 35 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2601598

Inhaled siRNA ARO-RAGE safely targets pulmonary inflammation, demonstrating effective delivery and engagement in asthma patients and healthy volunteers. by O'Carroll M, Kasahara D (...) Salathe M et 12 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Bacterial lysate OM-85 fails to prevent wheezing illnesses in preschool children, showing no significant impact compared to placebo. by Morgan WJ, Mauger DT (...) Martinez FD et 18 al. in Lancet #MedSky 👉 get more here 📖 read the article: https://www.thelancet.com/retrieve/pii/S0140673626014431

Navigating pediatric care for Jehovah's Witnesses demands ethical sensitivity, individualized strategies, and a balance between beliefs and medical safety. by Weaver MS, Takemoto C and Johnson LM in Blood #MedSky 👉 get more here 📖 read the article: https://#

Pulmonary nodule management hinges on type: solid nodules stable for 2 years are benign, while subsolid nodules require closer scrutiny. by Callister MEJ and Silvestri GA in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMcp2515063

Balanced fluids do not improve kidney outcomes in septic shock over 0.9% saline; both treatments yield similar patient results. by Balamuth F, Weiss SL (...) Kuppermann N et 59 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2601969

COVID-19 vaccines significantly lower hospitalization risks and serious outcomes across various age groups without new safety concerns. by Lipson RA, Senerth E (...) Morgan RL et 14 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2853778

14-day ambulatory ECG monitoring fails to significantly reduce syncope episodes in patients with unexplained causes post-emergency evaluation. by Reed MJ, Goodacre S (...) Taylor L et 14 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2605812

New Guidelines Highlight Top Medications for Effective Migraine Prevention: Galcanezumab and Erenumab Lead the Charge. by Pringsheim T, Smith DB (...) Potrebic S et 19 al. in Neurology #MedSky 👉 get more here 📖 read the article: https://www.neurology.org/doi/10.1212/WNL.0000000000218112

Aspirin omission during primary PCI in STEMI patients increases risk of death, stroke, or heart attack compared to dual therapy. by Takahashi K, Kozuma K (...) Nakazawa G et 24 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2606997

Recombinant shingles vaccine cuts cardiovascular risk by up to 12%, highlighting its potential cardioprotective benefits in older adults. by Corsi-Zuelli F, Li F (...) Taquet M et 4 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Formulary denials surged 67% from 2018 to 2024, causing significant treatment delays and medication access issues for patients. by Levy JF, Alexander GC, Vabson B and Ippolito BN in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2851461

Survodutide significantly outperforms placebo, achieving over 12% weight loss in obese adults after 76 weeks. by le Roux CW, Wharton S (...) Kaplan LM et 21 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2600751

High-dose methotrexate fails to reduce CNS relapse in ultra high-risk large B-cell lymphoma, challenging its routine use for prophylaxis. by Wilson MR, Lewis KL (...) Eyre TA et 36 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-26-00947

Arginine therapy fails to hasten recovery from acute pain crises in sickle cell disease, showing no benefits over placebo. by Morris CR, Hatabah D (...) Dampier C et 29 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2853065

Opioid prescriptions surge by 19% at teaching hospitals during Joint Commission inspections, highlighting pressure on clinicians amid scrutiny. by Cron DC, Worsham CM, Bray CF and Jena AB in BMJ #MedSky 👉 get more here 📖 read the article: https://www.bmj.com/content/394/bmj-2026-100320

Ambient scribes risk undermining patient-centered care; integrating narrative analysis is essential for harnessing their full potential. by Ostherr K, Engebretsen E and Woods A in Lancet #MedSky 👉 get more here 📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0140673626013814

Low stimulation thresholds in pedicle screws during pediatric scoliosis surgery do not correlate with increased neuromonitoring alerts or adverse outcomes. by Wolf JJ, Shobode M (...) Kadado A et 8 al. in Spine (Phila Pa 1976) #MedSky 👉 get more here 📖 read the article:

Timely surgery within two years enhances recovery in degenerative cervical myelopathy, improving quality of life and physical function. by Nagoshi N, Yamane J (...) Watanabe K et 13 al. in Spine (Phila Pa 1976) #MedSky 👉 get more here 📖 read the article:

Tissue aging clocks leverage histopathological imaging to unveil organ-level decline, linking lifestyle factors and diseases like Alzheimer’s. by Abila E, Buljan I (...) Rendeiro AF et 26 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Innovative chemo-free regimen achieves 100% overall response and 86% complete response in untreated indolent B-cell lymphoma patients. by Lynch RC, Poh C (...) Gopal AK et 14 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02906

Secukinumab outperforms placebo in achieving sustained remission for relapsed polymyalgia rheumatica while reducing glucocorticoid usage. by Stone JH, Buttgereit F (...) Patekar M et 22 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2602567

Selpercatinib significantly boosts event-free survival in early-stage NSCLC, achieving 92% at two years vs. 61% with placebo. by Wu YL, Hochmair M (...) Drilon A et 16 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2602628

Single dose of VERVE-102 delivers significant, lasting reductions in PCSK9 and LDL cholesterol levels in genetic heart disease patients. by Vafai SB, Täubel J (...) Kathiresan S et 28 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2601283

Insulin resistance impairs mitochondrial function, delaying lactation onset and increasing neonatal weight loss in postpartum women. by Meng X, Elajnaf T (...) Hannan FM et 12 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/197311

Lactate triggers fibrotic progression in kidney injury by modulating DDX18, pinpointing a new therapeutic target for chronic kidney disease. by Dong L, Xie J (...) Zuo D et 12 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/201848

Revising treatment guidelines is crucial; age alone is insufficient for guiding adjuvant therapy in lower-grade glioma patients. by Kinslow CJ, Minniti G (...) Wang TJC et 34 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01846

Inflammatory fibroblast states in Crohn's disease are sustained by epigenetic mechanisms, presenting new targets for therapeutic intervention. by Koplev S, Sharma O (...) Friedrich M et 42 al. in Nat Immunol #MedSky 👉 get more here 📖 read the article:

Adjuvant nivolumab fails to improve disease-free survival in resected non-small cell lung cancer, even with high PD-L1 expression. by Chaft JE, Sun Z (...) Ramalingam SS et 26 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2849809

Serial amnioinfusions before 26 weeks significantly improve neonatal survival rates in anhydramnios due to fetal kidney failure. by Miller JL, Baschat AA (...) Atkinson MA et 40 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2850820

Combination of Osimertinib and Chemotherapy Boosts Progression-Free Survival in EGFR-Mutated NSCLC with TP53 Mutations by Zhou T, Zhou H (...) Zhang L et 20 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2852628

Intracranial DRI γδ T cell therapy shows promise against glioblastoma with manageable toxicity and improved survival outcomes. by Nabors LB, Lobbous M (...) Lamb LS et 10 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02463

GLP-1 receptor agonists emerge as potential game-changers in cancer therapy, linking metabolic health to improved outcomes in obesity-related malignancies. by Temperley HC and Kelly ME in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-26-00062

HLA loss in leukemia relapse post-transplant affects 15.6% of patients, highlighting the need for tailored donor selection strategies. by Fleischhauer K, Toffalori C (...) Vago L et 47 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-26-00113

Aging parents and ART significantly increase de novo mutations, impacting gestational duration and potential neurocognitive development in offspring. by Qin N, Dai J (...) Hu Z et 27 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Continuing Original Therapy Plus Brain Radiotherapy Boosts Survival for Patients with Brain-Only Progression in Small Cell Lung Cancer by Lu S, Jia J (...) Zhu H et 6 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02536

HIV Treatment: Doravirine-based Regimen Links to Less Weight Gain and Comparable Viral Suppression Compared to Dolutegravir. by Woods J, Lebina L (...) Sokhela SM et 13 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2852404

PRISM2 revolutionizes computational pathology, enhancing cancer detection accuracy while bridging diagnostics and AI through multimodal learning. by Vorontsov E, Shaikovski G (...) Liu S et 16 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Ewing Sarcoma Study Reveals 72.6% Three-Year Survival; Histologic Response Emerges as Key Prognostic Factor in Landmark Analysis. by Valentin T, Winter S (...) Brennan B et 19 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02516