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People with long COVID reported significantly better functioning and symptom improvements after taking low-dose naltrexone, according to a small retrospective cohort study. Read more at: https://www.medpagetoday.com/meetingcoverage/idweek/123580

Patients with MET-altered advanced non-small cell lung cancer lived significantly longer with a targeted combination after progression on standard-of-care osimertinib (Tagrisso), a large randomized trial showed. #ESMO26 https://www.medpagetoday.com/meetingcoverage/esmo/123596

Nearly one in 10 adults hospitalized with respiratory syncytial virus (RSV) infection died in the hospital or within 30 days of discharge, according to a CDC analysis of eight RSV seasons. Read more at: https://www.medpagetoday.com/meetingcoverage/idweek/123563

A pneumococcal conjugate vaccine covering 25 serotypes was safe and generated immune responses among infants that were comparable to the current 20-valent vaccine (Prevnar 20), a phase II trial showed. https://www.medpagetoday.com/meetingcoverage/idweek/123598

Should we let robots be doctors? 🤖🩺 According to @zekeemanuel.bsky.social, physicians "need to be willing to experiment with models that put AI in control." Join us for a LIVE conversation on October 29 at 12:30 pm ET -- register now: ehgroup.zoom.us/webinar/regi... @jeremyfaust.bsky.social

Supplementation with high-dose cholecalciferol (vitamin D3) did not improve overall survival in patients receiving dialysis for end-stage kidney disease, according to findings from the SIMPLIFIED trial. #KidneyWk @asnkidney.bsky.social https://www.medpagetoday.com/meetingcoverage/asn/123589

A next-generation KRAS G12C inhibitor significantly improved survival outcomes versus first-generation drugs for previously treated advanced or metastatic non-small cell lung cancer, a phase III trial showed. Read more at: https://www.medpagetoday.com/meetingcoverage/esmo/123588

Strict dietary protein restriction was associated with worse clinical outcomes in patients with CKD who were not dependent on dialysis, a South Korean prospective cohort study suggested. #KidneyWk @asnkidney.bsky.social https://www.medpagetoday.com/meetingcoverage/asn/123590

Results from a large randomized trial were reported at #ESMO26. At the conclusion of the talk, the audience responded with a standing ovation and cheering that lasted almost a minute. Here's why ⬇️👀 www.medpagetoday.com/meetingcover...

MS patients exposed to a GLP-1 receptor agonist had lower rates of relapse activity & steroid use, reduced incidence of optic neuritis, & fewer demyelinating events compared with those who didn't use these agents, a real-world study showed. https://www.medpagetoday.com/meetingcoverage/ectrims/123593

Perioperative treatment with durvalumab + neoadjuvant EV significantly improved EFS & OS compared with radical cystectomy in patients with MIBC who can't, or won't, tolerate cisplatin-based chemotherapy, according to the VOLGA trial. #ESMO26 https://www.medpagetoday.com/meetingcoverage/esmo/123570

Patients with heavily pretreated HR-positive breast cancer lived twice as long without disease progression with the novel ADC iza-bren, a randomized trial from China showed. #ESMO26 @myesmo.bsky.social https://www.medpagetoday.com/meetingcoverage/esmo/123574

Twice daily oral doses of 100 mg of the BTK inhibitor remibrutinib reduced relapses more than teriflunomide (Aubagio) in patients with relapsing MS, data from two identical phase III studies showed. #MSToronto2026 https://www.medpagetoday.com/meetingcoverage/ectrims/123572

The investigational CD19-directed CAR T-cell therapy zola-cel showed the potential to treat people with highly active relapsing MS and progressive MS in a phase I study, but a fatal event occurred during the trial. #MSToronto2026 https://www.medpagetoday.com/meetingcoverage/ectrims/123565

Endovascular therapy made promising forays into milder and later-presenting large vessel occlusion strokes in a pair of multicenter, open-label trials from China. https://www.medpagetoday.com/cardiology/strokes/123562

Daily low-dose aspirin did not significantly reduce major vascular events in adults with chronic kidney disease, the randomized ATTACK trial showed. @asnkidney.bsky.social #KidneyWk https://www.medpagetoday.com/meetingcoverage/asn/123579

Overall survival in ES-SCLC approached 2 years with tarlatamab (Imdelltra) combination maintenance therapy after first-line chemoimmunotherapy, a large randomized trial showed. #ESMO26 @myesmo.bsky.social @stephenvliu.bsky.social https://www.medpagetoday.com/meetingcoverage/esmo/123569

Estrogen-only menopausal hormone therapy was associated with a slightly higher incidence of autoimmune disease compared with estrogen-progestogen therapy, a retrospective cohort study suggested. Read more at: https://www.medpagetoday.com/meetingcoverage/tms/123560

Significant proteinuria reductions were reported in phase III interim analyses assessing two investigational IgA nephropathy agents and a third that was recently granted accelerated approval. #KidneyWk @asnkidney.bsky.social https://www.medpagetoday.com/meetingcoverage/asn/123571

In an #OpEd for MedPage Today, forensic psychiatrist Susan Hatters Friedman, MD, MSt, draws on her work with women convicted of fraud to analyze Nathan Fielder and Lance Oppenheim's Liz Holmes documentary, "You Can See Everything." www.medpagetoday.com/opinion/seco...

"The public health consequences of these manufactured undercounts and forced errors will be immediate and severe." Read the op-ed from Debra Houry, MD, MPH, at: https://www.medpagetoday.com/opinion/second-opinions/123540

Treatment with SGLT2 inhibitors was linked with modest but statistically significant increases in hemoglobin & hematocrit levels across a broad spectrum of patient populations, according to a systematic review & meta-analysis. #KidneyWk https://www.medpagetoday.com/meetingcoverage/asn/123568

An investigational ADC significantly reduced the risk of disease progression or death in patients with HER2-low metastatic breast cancer, a Chinese phase III trial showed. #ESMO26 @myesmo.bsky.social @barbarapistill2.bsky.social https://www.medpagetoday.com/meetingcoverage/esmo/123561

Patients with recurrent or metastatic HER2-low breast cancer had dramatic improvement in PFS when treated with a novel ADC targeting HER2, a large randomized trial showed. #ESMO26 @myesmo.bsky.social @barbarapistill2.bsky.social https://www.medpagetoday.com/meetingcoverage/esmo/123566

Cancer-related cognitive impairment (CRCI) in breast cancer survivors improved significantly after treatment with the glutamate regulator oxaloacetate, a preliminary single-arm clinical study showed. Read more at: https://www.medpagetoday.com/hematologyoncology/breastcancer/123559

Men with very high-risk prostate cancer had a significantly lower risk of metastasis when they received darolutamide (Nubeqa) in addition to ADT and RT, a randomized trial showed. #ESMO26 @myesmo.bsky.social https://www.medpagetoday.com/meetingcoverage/esmo/123578

Investigational tovecimig combined with paclitaxel significantly improved the response rate & PFS in patients with previously treated advanced or metastatic biliary tract cancer, according to COMPANION-002. #ESMO26 @myesmo.bsky.social https://www.medpagetoday.com/meetingcoverage/esmo/123567

At 6 months of age, most U.S. infants no longer had detectable levels of maternal neutralizing antibodies for measles, potentially leaving them at risk of an infection before their first dose of the MMR vaccine, per a retrospective analysis. https://www.medpagetoday.com/meetingcoverage/idweek/123558

Two IgA nephropathy drugs -- atacicept (Trutakna) and sibeprenlimab injection (Voyxact) -- showed they were able to slow kidney function decline in final phase III trial efficacy analyses. #KidneyWk @asnkidney.bsky.social https://www.medpagetoday.com/meetingcoverage/asn/123564

Leaving people out of the census does not make their health needs disappear. An accurate count helps us plan care, direct resources, and prepare for disasters. Comment by Nov 2 in the FRN (link in my article) My latest in @medpagetoday.com: www.medpagetoday.com/opinion/seco...

The federal government's 340B program, which provides deeply discounted drugs to hospitals that serve low-income patients, continues to be a source of controversy for hospitals and drug companies. Read more at: https://www.medpagetoday.com/publichealthpolicy/washington-watch/123537

Attention deficit-hyperactivity disorder (ADHD) medications may improve subjective experiences with menopausal brain fog, but more research is needed, a scoping review suggested. Read more at: https://www.medpagetoday.com/meetingcoverage/tms/123539

Taking the nonhormonal dual NK receptor antagonist elinzanetant (Lynkuet) at bedtime did not result in residual daytime sleepiness and actually improved sleepiness scores in postmenopausal women, according to a post-hoc analysis. https://www.medpagetoday.com/meetingcoverage/tms/123556

Donating a kidney was associated with a higher risk of gestational hypertensive disorders during subsequent pregnancy, though complications were rare overall, according to a Canadian matched cohort study. Read more at: https://www.medpagetoday.com/meetingcoverage/asn/123521

HHS announced an update Thursday to the National Plan to Address Alzheimer's Disease and Related Dementias that includes investment in projects focused on earlier detection and intervention. https://www.medpagetoday.com/neurology/alzheimersdisease/123535

The CDC has issued a Level 3 emergency response for dengue outbreaks in Florida and another U.S. territory, the agency's eighth emergency response activation this year. Read more at: https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/123530

The anti-CD20 agent rituximab was associated with a higher risk of IBD in people with relapsing-remitting MS compared with other disease-modifying treatments, a population-based cohort study in Sweden showed. #MSToronto2026 https://www.medpagetoday.com/meetingcoverage/ectrims/123547

In an #OpEd for MedPage Today, forensic psychiatrist Susan Hatters Friedman, MD, MSt, draws on her work with women convicted of fraud to analyze Nathan Fielder and Lance Oppenheim's Liz Holmes documentary, "You Can See Everything." https://www.medpagetoday.com/opinion/second-opinions/123551?trw=no

Disparities in geographic access to neurologists, specialists, and MRI facilities contributed significantly to diagnostic delays in multiple sclerosis, a retrospective study showed. #MSToronto2026 https://www.medpagetoday.com/meetingcoverage/ectrims/123538

Long-term vancomycin suppression appeared to help prevent recurrences of C. Diff infections & did not lead to a substantial increase in vancomycin-resistant Enterococcus, according to a retrospective cohort study. #IDWeek2026 https://www.medpagetoday.com/meetingcoverage/idweek/123543

Adjuvant treatment with the mRNA-based cancer vaccine intismeran autogene plus pembrolizumab significantly improved recurrence-free survival in patients with resected stage IIB-IV melanoma, a study showed. @gvlongphdmd.bsky.social #ESMO26 https://www.medpagetoday.com/meetingcoverage/esmo/123549

Real-world data backed the effectiveness of second-season nirsevimab (Beyfortus) immunizations against hospitalizations for children at high risk for severe RSV illness. #IDWeek2026 @idweek.bsky.social https://www.medpagetoday.com/meetingcoverage/idweek/123536

Neurokinin-receptor antagonists improved sleep disturbances in menopausal women, a meta-analysis of randomized controlled trials showed. #MenopauseSocietyMtg @menopausesociety.bsky.social https://www.medpagetoday.com/meetingcoverage/tms/123533