Megan Behringer

Megan Behringer

@megbehri.bsky.social

Assistant Professor @VanderbiltU BioSci ⚓️ | Dog mom 🐕and sunset appreciator 🌅| Experimental evolution of microbes in stressful and structured environments 🧫🧪 | microbial epimutations 🧬|

977 followers466 following64 posts

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New Preprint 🚨: Led by Ph.D student, Ashlynn Bruder, we explore how feast/famine cycles in our LTRS system influence temporal selection on new mutations. Reconstruction of mutations reveals environment-dependent epistasis + increased fitness during both feast and famine conditions. Summary Fig ⬇️

bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social

Environment-dependent epistasis shapes adaptation to fluctuating resources. https://www.biorxiv.org/content/10.64898/2026.07.31.742109v1

Gotta love my lab asking Dan Hartl to sign the lab copy of Hartl and Clark. Really glad I got to meet with him today, such an interesting to chat with!

Megan Behringer reposted

Come be my colleague at Vanderbilt ⚓️! We have an Open-Rank Tenure Track search for a Theoretical Biologist in the Dept. Of Biological Sciences! Vandy BioSci is an awesome group of researchers with diverse interests. See Application Information Below ⬇️

Ann T. Tate@annttate.bsky.social

Please RT: Do you use math to address interesting biological problems? Join us at Vanderbilt BioSci! We are conducting an open-rank TT search in Theoretical Biology: apply.interfolio.com/194619. We are a friendly and collaborative department with interests spanning a range of biological disciplines!

Megan Behringer reposted

“Bacterial growth is straightforward to measure, complex in origin and exquisitely sensitive to environmental and genetic perturbations.” Fantastic opening sentence to a deeply interesting topic. Never thought about bacterial growth like this before. #MicroSky #Bacteria

Megan Behringer reposted

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Megan Behringer reposted

I talked about these papers #smbe2026. If you are interested in doing research (PhD or Postdoc) on this topic, get in touch! (if were there, sorry for the abrupt end; somehow timing got off) pubmed.ncbi.nlm.nih.gov/41763210/ pubmed.ncbi.nlm.nih.gov/39146405/ pubmed.ncbi.nlm.nih.gov/41699381/

Nadia Aubin-Horth@naubinhorth.bsky.social

Really enjoyed @christianlandry.bsky.social talk on Evolutionary biochemistry of gene duplication at #smbe2026 (yes he’s my husband but the second part of the talk was new results I hadn’t seen!)

Megan Behringer reposted

Comparative analysis of monocultures vs cocultures for >600 generations reveals that cross-feeding can limit the emergence of loss-of-function mutations. Congrats to Dr. Ying-Chih (Ella) Chuang and coauthors (@megbehri.bsky.social +others)! journals.asm.org/doi/10.1128/...

journals.asm.orgReciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies | Applied and Environmental MicrobiologyBacteria commonly engage in cross-feeding, where nutrients are transferred between neighbors. Cross-feeding is thought to alleviate energy expenditures for genes whose role can be met by cross-fed nutrients, leading to eventual gene loss. However, few examples have been documented, especially in comparison to monocultures that lack a cross-feeding partner. We grew cocultures pairing phototrophic Rhodopseudomonas palustris with fermentative Escherichia coli alongside corresponding monocultures for 650–800 generations. While coculture conditions required obligate exchange of nitrogen and carbon, additional cross-feeding of adenine and iron likely occurred. Contrary to expectations, dependencies for iron and unknown compounds emerged in monocultures, but expected iron and adenine dependencies were not observed in cocultures. Low expression of iron scavenging and adenine synthesis genes in cocultures suggested that cross-feeding repressed expression, thereby lowering gene cost. Thus, although cross-feeding can sometimes make costly genes dispensable, there are also cases where cross-feeding lowers gene cost, thereby promoting gene retention.

I’ve been thinking about this a lot lately and how organized sports prepares you academic science. Sports instill key skills like coachability, practicing on your own time, rebounding from failure, pushing yourself to keep improving, & knowing that results take time and consistent effort.

Springer Nature@springernature.com

In his previous career as a goalkeeper, failure felt clear. Thinking that his sport taught him how to handle failure during his PhD, Javier Nion Fieira found his experiences in elite sport were easier to analyse and process than those in the lab: spklr.io/63325EKlXR #PhDSky #AcademicSky

Yes! Let’s go! All aboard the microbial epigenetics train! 🚂

Nirodha Weeraratne@nirodhaweeraratne.bsky.social

🦠 Can microbes think? 🍄 Can they learn, remember, and react? 🤔 "Cognition without brains? Learning and memory in microorganisms" by @kostchristian.bsky.social lab raises some legit #Points2Ponder. #MicrobeMatters #MicrobialMemory

Behringer lab is heading into summer on the highest note possible. 🎼 1) William McLaughlin got the NOA for his USDA-NIFA predoctoral fellowship! 2) I received the NOA for the NSF CAREER! 3)Manuscript led by Wenhan Zhu’s lab w/ contributions from @owenfhale.bsky.social & I is online now at Cell!

Every young genome biologist around 2007 knew just how influential and complicated Craig Venter was. Learning about the human genome, and yacht expeditions collecting ocean microbiomes, were major contributors to my interest in bioinformatics when I was an undergrad finding my way in science. RIP.

Excited to share this new Preprint from our lab led by PhD Candidate Carl Stone (defending Tuesday). Here we present a framework for longitudinal rbTn-Seq and apply it to the Microbial extended growth curve to resolve the fitness seascape through growth, death, and long-term stationary phase!

bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social

Bayesian analysis of longitudinal RB-TnSeq resolves the fitness seascape in fluctuating environments https://www.biorxiv.org/content/10.64898/2026.02.11.703069v1

Megan Behringer reposted

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

Megan Behringer reposted

Now that we’re back, I want to promote this awesome work from our group led by former UG Researcher, Gillian Patton (now a Ph.D student at Wash U) published in Evol. Letters! We blocked a first step mutation that typically promotes biofilm formation to see how this roadblock influences evolution.

Evolution Letters@evolletters.bsky.social

Evolution isn’t always forward-looking. Experiments show that an early, beneficial mutation can trap E. coli on a local fitness peak, preventing ecotype diversification in structured environments and highlighting the role of G×E interactions. academic.oup.com/evlett/advan...

This is a huge honor and we’re so excited to get started on this new direction for our group stemming from the work of William McLaughlin, a Ph.D. Candidate in our lab! Major thanks to our scout, Paul Turner and Hypothesis Fund for seeing the potential in this project! Time to get to work! 🧬🧫🧪

Hypothesis Fund@hypothesisfund.bsky.social

2/ Awardee @megbehri.bsky.social will study how chaotic dynamics arise in microbial🦠 populations. Her research could transform how we predict microbiome dysbiosis across human health and beyond. 🥳 Congrats Dr. Behringer! @vuartsci.bsky.social 🙏 #HFScout @paulturnerlab.bsky.social

We found that LAB, and L. Acidophilus in particular, have very high mutation rates. Mutations are quite biased towards G:C ➡️ A:T and A:T➡️G:C; and this is very apparent in L. acidophilus near the ori.

We suspect that the very elevated mutation rate of L. acidophilus is influenced by its domestication status - we observe many losses of DNA repair genes across the species. Thus, the mutation rates of L. acidophilus may be actively evolving and an ideal species for studying mutation rate evolution.

Megan Behringer reposted

Carl is an awesome science communicator. He’s finishing up his PhD focused on bacterial epigenetics and evolution. He’s a rockstar at applying Bayesian statistical approaches to large omics datasets!

Given that there are 435 voting members of Congress, I would have hoped for more than 25% of House members to support American innovation in science and technology. 112? That’s it? No one else wants answers?!?!

Congressman Bill Foster@repbillfoster.bsky.social

NEWS: I just led 112 of my colleagues in demanding answers from the Trump Administration on their funding freeze of the National Science Foundation. Cutting off NSF funding threatens vital research, stalls innovation, and risks ceding global scientific leadership to China.

Megan Behringer reposted

Thanks for the Signal Boost, Ákos! We’re so happy to see our review discussing Rho as an evolutionary capacitor out in Transcription! It’s an exciting follow up to our recent research article & opens up a discussion of where we expect evolutionary capacitors to exist b/w the genotype/phenotype gap.