Michal Kolář

Our new contribution about #ribosomes. While preparing computer simulations for another project, we noticed that many r-protein parts were missing from the #cryoEM model. Surprisingly, we found this to be a general feature: a coat of #IDPs on the ribosome's surface. www.biorxiv.org/content/10.6...

It’s time for the World Cup final with one of the greatest footballers that may be playing his last cup So time for a short thread on a link between Messi and an intrinsically disordered protein. 1/n

It will be our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk on 16th September. Please join us in person or online and celebrate all things #biophysics www3.mrc-lmb.cam.ac.uk/sites/nextge...

Do you have a bold, daring vision how to transform research in biology? Are you a young scientist within 7 years since your PhD? Submit your idea by July 31 to the Dream Biology Award competition and you can win the first prize of €10,000! More details at dreambiologyaward.org

#RNAsky .... Do we have to understand that Ribosomes are flufy sticky blobs rather than granulous dense gobs 🤔🤓

🔬 This tenure-track position is roughly comparable to an #assistantprofessor at a US university or to a #newinvestigator position at Max Planck Institutes in Germany. See more ► www.uochb.cz/en/open-posi... ⤵️ #openposition #iocbprague #iocb #compchem

🌽🧬🐛 Together with @natcomms.nature.com and Scientific Reports, we invite articles in all areas of research investigating the roles of RNA in plant biotic interactions (including plant-microbe, plant-insect, and plant-plant interactions). www.nature.com/collections/...

New research shows bacteria can redefine stop codons by shortening tRNA anticodon stems. This "extended superwobble" proves tRNAs aren't passive—they're active drivers that can evolve entirely new genetic codes! doi.org/10.1093/nar/...

We open up to two Junior PI positions at UCT Prague, Czechia @vschtpraha.bsky.social. Broadly defined chemistry-related projects will be considered. A support from any department must be negotiated prior application. Feel free to contact me for further info or visit www.vscht.cz/research/dag....

🧬Linker histone H1 suppresses H4-acetylation–induced H3 N-tail acetylation by altering tail dynamics without affecting the nucleosome core, indicating that H1 restricts euchromatin formation. Find out more in this latest article at www.nature.com/articles/s42...

🧬A new review article discusses the consequences of mutations in genes associated with rare hereditary diseases linked to #G-quadruplex -induced replisome stalling, as well as the molecular functions and cellular pathways of these G4-interacting proteins. doi.org/10.1038/s420...

How can an ordinary clam (well, actually more than 1,600 of these shells) reveal what the fjords on Svalbard looked like thousands of years ago? 🧵👇

Hugo and his poster about the enormous flexibility of the ribosomal tunnel constriction. Preprint available here: www.biorxiv.org/content/10.6...

Huenfeld computational biophysics, 25th anniversary edition. Final slide of the final talk. I feel it the same.

My first author paper is published in @narjournal.bsky.social , co-led with Satish Nandipati and Ambar Kachale. In this work, we build on the implications of the unusual genetic code features of Blastocrithidia nonstop... #RNAsky #RNA #evolution #molecular academic.oup.com/nar/article/...

Our latest contribution is out! In this highly collaborative paper, we show that tRNAs with a 4-base-pair anticodon stem are surprisingly frequent across organisms. Our atomistic MD simulations reveal the role of the 5th base pair. academic.oup.com/nar/article/...

Thermus thermophilus forms two distinct type IV pili. Cryo-electron microscopy, mutagenesis, structural predictions and simulations reveal their structures, glycan flexibility, and a hypothetical model of pilus assembly. www.nature.com/articles/s42...

Analysis and Sampling of Molecular Simulations with Adversarial Autoencoders by @guted.bsky.social doi.org/10.1063/5.03...

There is an unplanned power outage in Prague 6. It appears that the servers of the Czech Science Foundation GACR (including #GRIS) are affected and therefore currently unreachable.

Our recent investigation of the constriction in the bacterial ribosomal tunnel is online. Unbiased all-atom MD simulations of the entire ribosome and PDB analysis show, how flexible the constriction is. The flexibility is modulated by short nascent polypetides.

🧬Submissions are still open for our DNA repair and human disease Collection, a cross-journal Collection, highlighting new research and methodological advances. www.nature.com/collections/... ⚠️ Submission Deadline: 31 January 2026

💡Since November 2025, @springernature.com has introduced "Articles in Press", an initiative giving authors earlier visibility without compromising the quality or integrity of the final publication. ⌛Faster access to accepted research! For more information: support.springernature.com/en/support/s...

Some thoughts on the chronic underfunding of the Czech Science Foundation. Much of this problem stems from the recent Ministry of Education’s sloppy implementation of funding for non-teaching staff at grammar schools. gacr.cz/informace-o-...

New publication about peptide transport through confined space with some implications for MD simulations of nascent polypeptides in the ribosomal exit tunnel. pubs.rsc.org/en/content/a...

The 14% success rate the main Czech funding scheme for fundamental research is simply a disaster. gacr.cz/en/next-year...

Excited to share a fantastic set of sessions coming up at the MDDB Conference: Day 1: Large-scale MD simulations Day 2: MD kinetics and free energy / Industrial applications of MD Day 3: Innovative applications of MD to biological systems Explore more and register at ➡️ mddbr.eu/conference/ #MDDB

Happy to take part in the workshop. Lots of inspiring discussions. The take-home message: there are many interesting research problems, but only some are truly important.

Day 1 of the winter semester. Good luck to all of us @vschtpraha.bsky.social.

At EMBL @events.embl.org , they know how to conclude a conference. #EMBLProtein

It's 93. Come and chat on Thursday. #EMBLProtein

Hiking time with Hlouchova lab during our GACR project retreat in Jachymov. A lot of discussions on protein-RNA interactions under probiotic conditions🦠

🥇 Václav Verner (PORG) won 2nd place in the world 🥈 Matěj Pěnička (Gymnázium Nad Alejí) 🥈 Ondřej Michal (Gymnázium Botičská) 🥉 Adam Horák (Gymnázium Hranice)

🗣️ We are pleased to announce that our 2024 Annual Report is out and for the first time in English! ➡️ czexpats.org/en/about-us/...

My temporary office at #EBSA in Rome.

My flight to Rome delayed by 12 hours. Saying goodbye to day 1 of the #EBSA conference and I'm hoping to make it for day 2!

Heading to #EBSA in Roma and packing my poster to a luggage. Not a fan of poster tubes 🫣 Full text arxiv.org/abs/2503.21357

For Czech readers: The Prague administration has once again shown its incompetence - this time by failing to manage basic demographic data. As a result, young students are paying the price when trying to get into high schools. www.eduin.cz/clanky/nafou...

English-speaking colleagues welcome! Summer’s around the corner, and if you're in the mood for a break from the lab or the office, pop by Cafe Prostoru on June 10 to grab a beer and have a chat 😎 If you’re planning to join us, let us please know via the link above 🙏

I'll be there😎

For Czech readers: Some of the brightest Czech minds who made it to the finals of the @czexpats.bsky.social Award have short research summaries featured in the latest issue of @vesmir.bsky.social vesmir.cz/cz/casopis/s...

We are pleased to announce that the next speaker in the ProSE seminar series will be Dr. Klara Hlouchova with a talk on "Protein Structure Before LUCA" May 13, 4PM CET Registration link: tinyurl.com/prose-seminar4 Please share!

Our research group studies #ribosomes. Our favorite region of interest is the ribosomal tunnel. We realized that it has been missing a Wikipedia page until now, so we decided to create one. Read, edit, enjoy👇 en.wikipedia.org/wiki/Ribosom...

🌟 #PI_Forum Brno #5: Academic Leadership: The Big Picture is ahead! How does one lead a team vs. an institution? Join Irena Radová (MUNI) & Jiří Přibáň (Constitutional Court) to explore leadership in academia and beyond. 🗓️ 13 May 2025 📍CEITEC MU, room 211. Register: czexpats.org/en/udalost/p...