Michal Dibus

Michal Dibus

@midibu.bsky.social

Marie Skłodowska-Curie Postdoctoral Fellow at IvaskaLab

107 followers183 following18 posts

Michal Dibus reposted

Ivaska Lab
@ivaskalab.bsky.social

New paper alert! Michal Dibus and team show tensin-1 forms reversible condensates that act as reservoirs for adhesion proteins, tuning adhesion turnover and cell migration - a cool new role for phase separation in cell adhesion dynamics! Congratulations to the team 🎉! Paper here: bit.ly/4y9E8Xr

bit.lyAdhesion-derived condensates control component availability to regulate adhesion dynamics - Nature CommunicationsIntegrin adhesions allow dynamic cell-matrix interactions to regulate cell behaviour. Here, the authors reveal that tensin 1, a multidomain adaptor protein, forms condensates in cells that act as reve...
Michal Dibus@midibu.bsky.social

1/5 🎉 Finally, the results of my main postdoctoral project are out in @natcomms.nature.com! Adhesion-derived condensates control component availability to regulate adhesion dynamics bit.ly/4y9E8Xr Also excited to see the paper highlighted in Nat Comms Editors’ Highlights 🥳 bit.ly/44n4O9i

Michal Dibus
@midibu.bsky.social

4/5 - stress-mediated phosphorylation controls TNS1 condensate assembly and regulates adhesion phenotype - we also identified close association of TNS1 condensates with P-bodies

Michal Dibus
@midibu.bsky.social

3/5 - TNS1 phase separation is driven by its intrinsically disordered region (IDR) - IDR sequence grammar governs the biophysical properties of TNS1 condensates, and the TNS1 IDR regulates adhesion dynamics, cell migration and invasion

Michal Dibus
@midibu.bsky.social

2/5 We studied phase separation of the key adhesion adaptor protein tensin1 (TNS1). We show that: - TNS1 forms condensates that act as reversible reservoirs for adhesion proteins - Endogenous TNS1 condensates form upon acute adhesion disassembly and in response to limited integrin–ECM engagement

Michal Dibus
@midibu.bsky.social

Proud to be part of this cool story by @follainga.bsky.social, led by @guijacquemet.bsky.social and @johannaivaska.bsky.social. Go and have a look!

Guillaume Jacquemet@guijacquemet.bsky.social

Delighted to share the latest paper from the lab "Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers" Amazing work driven by @follainga.bsky.social with contributions from many. link.springer.com/article/10.1...

link.springer.comFast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO JournalThe rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...

Michal Dibus reposted

Guillaume Jacquemet
@guijacquemet.bsky.social

Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions " www.biorxiv.org/content/10.6... Work driven by @anagracanin.bsky.social A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social

biorxiv.orgFilopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functionsCancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover th...

Michal Dibus reposted

Johanna Ivaska
@johannaivaska.bsky.social

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

sciencedirect.comEPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migrationEpithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
Michal Dibus
@midibu.bsky.social

Fresh out of @ivaskalab.bsky.social on EPLINs' roles in integrin trafficking! Go have a look! 🎉

Paulina Morlay@drpaulinamoreno.bsky.social

Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau

bit.lyEPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migrationEpithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
Michal Dibus
@midibu.bsky.social

Grateful for the poster prize awarded by @febsopenbio.bsky.social at the #FEBS2025 congress! It was a pleasure to meet so many inspiring people and discuss some great science! @ivaskalab.bsky.social

febsopenbio.bsky.social@febsopenbio.bsky.social

🏆 Congrats to Michal Dibus for winning the daily poster prize from FEBS Open Bio today with his poster "Tensin 1 phase separation in regulation of integrin adhesion dynamics"👏 @midibu.bsky.social @ivaskalab.bsky.social #FEBS2025 #FEBSCongress2025

Michal Dibus reposted

Guillaume Jacquemet
@guijacquemet.bsky.social

- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).

Guillaume Jacquemet@guijacquemet.bsky.social

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

Michal Dibus reposted

Johanna Ivaska
@johannaivaska.bsky.social

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

nature.comDynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell BiologyConway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

Michal Dibus reposted

VickySanzMoreno
@vickysanzmoreno.bsky.social

We are offering an exciting project for aspiring clinical scientists! Cytoskeletal Dynamics in Circulating Tumour Cells from Breast Cancer Patients! Don't miss this opportunity to work at the interface between fundamental and clinical science @icr.ac.uk 😀! www.icr.ac.uk/study-and-ca...

icr.ac.ukPhD and MD(Res) for clinicians - The Institute of Cancer Research, LondonOur academic clinicians bring knowledge of clinical practice into the lab and take laboratory research back into the clinic to help cancer patients.

Michal Dibus reposted

Ivaska Lab
@ivaskalab.bsky.social

We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!

Michal Dibus
@midibu.bsky.social

We show that under low ahesion conditions Tensin 1 forms endogenous condensates to store inactive adhesion components. These can be released upon stress-mediated Tensin 1 phosphorylation to regulate adhesion dynamics.

Michal Dibus reposted

Ivaska Lab
@ivaskalab.bsky.social

Ivaska lab members are at the Fibronectin GRC at the gorgeous Renaissance Hotel in Tuscany! Come say hi to (L-R) Michalis, Megan, Omkar, Gautier and Michal if you haven't already 😀

Michal Dibus
@midibu.bsky.social

Grateful for the opportunity to participate in this Viewpoint with @follainga.bsky.social , @omkarjoshi.bsky.social and @guijacquemet.bsky.social : Time, the final frontier doi.org/10.1002/1878...

doi.orgFEBS PressThis article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imag...
Guillaume Jacquemet@guijacquemet.bsky.social

We wrote a small Viewpoint for Molecular Oncology with @follainga.bsky.social @omkarjoshi.bsky.social Michal Dibus via EACR @helloeacr.bsky.social Time, the final frontier febs.onlinelibrary.wiley.com/doi/full/10.... Hope you find it interesting

febs.onlinelibrary.wiley.comfebs.onlinelibrary.wiley.com

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