Malcolm Sim

Congrats to 2nd year PhD student Emery for her brilliant write up of this important preprint on Neoantigen vaccination www.nature.com/articles/s41...

🎓 Best of luck to Max Quastel, who’s defending his DPhil thesis today! He’ll be giving a pre-viva talk open to everyone, come along and cheer him on. Break a leg, Max! ✨ #CIODphil

Our #CIO DPhil student Lisha Jeena is about to give her pre-viva talk on the effects of HIV-associated inflammation on musculoskeletal health🦴. Come support Lisha in the NDMRB seminar room! Best of luck, Lisha 🍀 you’ve got this! 💪🎓

We’re happy to be in Liverpool for this years @britsocimm.bsky.social congress: In today’s “What’s hot in cancer immunology?” session, Prof David Withers presented our new data on an orthotopic colorectal cancer model for the first time! 🐭💪

CIO is at @britsocimm.bsky.social BSI congress in Liverpool. Look out for presentations, posters and session chairs from CIO members @witherslab.bsky.social @galvez-cancino.bsky.social @timmunologist.bsky.social @mjwsim.bsky.social

The Sim lab is at BSI Congress with two posters @britsocimm.bsky.social Come see what we’ve been up to! Numbers 400 and 403.

Tomorrow we welcome Jonathon Worboys from the University of Manchester to our CIO seminar series. Jon is a Wellcome research fellow and will give a talk titled ‘The nanoscale governance of TIGIT signalling and blockade’

Welcome DPhil class of 2025! Great to have you in CIO.

UK NK 2026 in Cardiff. January 9th. Be there. eventbrite.co.uk/e/uk-nk-confer… Hosted by Rich Stanton, Ceri Fielding & Eddie Wang

Delighted to be hosting the Oxford KIR Workshop 2026 April next year. Please register here and contact me regarding accommodation. www.oxforduniversitystores.co.uk/conferences-...

Any labs in Europe / US using Loderan products? Never heard of them but could save my lab a pretty penny www.lorderan.com/en-gb/produc...

Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.

Today we welcome Associate Prof. Amir Horowitz from the Tish Cancer Institute at Mt Sinai to the CIO Seminar Series. Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'

We're hiring! Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details! www.jobs.ac.uk/job/DOW691/r...

🎨 After lunch we had some team-building fun with a sciency embossing workshop 🧑‍🎨 so many creative scientists in the room! Huge thanks to Asma for teaching us a new skill!! #CIOawayday #embossing

🧪 We continued with an engaging afternoon poster session featuring more of our talented PhD students 🐣 Fantastic science, thoughtful questions, and great discussions all around. The future is bright! #CIOawayday

🐣 We followed with our Junior PIs telling us about their questions for the next 5 years 💡 Lots of exciting, cutting-edge new ideas that will hopefully materialise soon and bring even more new questions to #CIO 🤓 🥳 #CIOawayday @galvez-cancino.bsky.social @mjwsim.bsky.social

🌟 Fantastic morning poster session from our DPhil students 📚🧫 so much talent and fresh thinking on display! More to come this afternoon. #CIOawayday

✨ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers 🧑‍🔬👩‍🔬🧫 A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas 🤓 Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO 😉🙃 #ScienceLife

Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules https://www.biorxiv.org/content/10.1101/2025.06.20.660712v1

Fascinating preprint from @timmunologist.bsky.social @mjwsim.bsky.social and co-authors

Feeling proud and looking sharp! Repping the Centre for Immuno-Oncology in style 😎 🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here! Team spirit (and outfits) on point 💛🖤💙

Lucy, FHS student at @mjwsim.bsky.social’s lab, has outdone herself! Not only is this the prettiest cake we’ve seen 😍, but it’s also seriously delicious 🤤🍰 #LabLife #BakingScience

And we're off!! @timmunologist.bsky.social opens our third annual OCION Symposium ‪@oxfordmathematics.bsky.social today! Don't forget to visit our sponsors posters/exhibition stands. @imtadvances.bsky.social (STAND) @nanoporetech.com (STAND) @Immunocore (POSTER) @10xgenomics.bsky.social (STAND)

NK2026 in Italy!

Jet lagged and ready to rock #NK2025 in Tasmania

It’s Wednesday morning. There’s no more new Andor and I’m just supposed to carry on with my life.

chng.it/ZYvmHTMZnJ

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via @ukchange.bsky.social

Delighted to share our review, published in Matrix Biology, led by Subashan Vadibeler, Shannique Clarke & Su Phyu - understanding matrix biology in oesophagogastric cancer is essential to improve therapeutic options, we highlight existing knowledge & gaps here - www.sciencedirect.com/science/arti...

Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...

🎯 Wanna know how NK cells recognise viruses? Sign-up for this month's @dgfi-yi.bsky.social virtual seminar as we host @quirinhammer.bsky.social, who'll enlighten us on the molecular mechanisms underlying recognition of virus-infected cells by NK cells. Registration👇🏼 docs.google.com/forms/d/e/1F...

Delighted to be hosting the next KIR workshop in Oxford next year. Please save these dates if you're interested. More details to follow.

This year I'll be running 10k, 10 miles and a half marathon to raise awareness (with a just giving page too) for the ME Association - #millionsmissing can't run so I'll do it for them

academic.oup.com/jimmunol/adv...

🔬CIO is at #BSIOxford today! 🎯 Beinig Li gave a fantastic talk this morning on peptide-specificity of KIR during the Innate Immunity session. 🤓You still have the chance to check out all the CIO insightful posters—lots of cutting-edge science on display! #Immunology #BSI2025 @britsocimm.bsky.social

....and thanks to Beining Li for a brilliant talk on the peptide specificity of KIR with yeast display of HLA-C #OIS25 @oxcio.bsky.social

🌟 Early Bird Extension 🌟 We’ve extended the Early Bird registration for NK2025! This is your chance to lock in your spot at a discounted rate! 📅 Don't miss out – Register by Friday 28 March 2025! ! #EarlyBirdExtension #NK2025

The Trp Flip! Great paper from Brian, Chris & co

Had the best time hosting @malmberglab.bsky.social this week. Two great talks, two great tennis sessions and not enough margaritas.

A really fun day out at the UK NK cell meeting. Thanks to @mjwsim.bsky.social for organising a great day and for inviting @sam-chamberlain.bsky.social to talk about his work on how RIFINs bind to the KIR immune receptors to modulate NK function in malaria.

Heading back home after a full week at the University of Oxford, hosted by brilliant @mjwsim.bsky.social. Very inspired by all the amazing science in the UK NK community and at the Center for Immuno-Oncology.

Eric O'Neill and I are excited to welcome over 120 NK cell enthusiasts to the UK NK meeting, to be held in Oxford in January. Details can be found here sites.google.com/view/uknk202...