Nature Reviews Cancer

🎉 Our 25th Anniversary Issue is now live! 🎉🥳 Featuring #Reviews on - 3D tumour atlases - The systemic impact of EVs - Pyroptosis & antitumour immunity #Roadmap on - Early-onset CRC prevention Plus #Viepoints #Comments &#WorldView Check it out 👇 http://dlvr.it/TVcqwv

dlvr.itSingle-cell tumour phylogeneticsNature Reviews Cancer, Published online: 26 October 2026; doi:10.1038/s41568-026-00992-2Single-cell sequencing has transformed the study of tumour evolution by enabling high-resolution reconstruction of cancer phylogenies. This Review discusses the models, assumptions and computational approaches underlying single-cell tumour phylogeny inference, and it highlights emerging applications in cancer biology, patient stratification and evolutionary forecasting.

dlvr.itCancer theranosticsNature Reviews Cancer, Published online: 22 October 2026; doi:10.1038/s41568-026-00983-3Theranostics integrates diagnostic imaging with targeted therapy to enhance cancer treatment. In this Review, Sofias et al. discuss recent advances in radiotheranostic strategies, advances in nanotheranostic and microtheranostic platforms, and image-guided therapeutic and surgical interventions in oncology.

dlvr.itHit the pause buttonNature Reviews Cancer, Published online: 22 October 2026; doi:10.1038/s41568-026-00995-zIn a recent study, García-Gómez et al. identify an adaptive proliferative pause program that supports the survival of micrometastatic cells during early brain colonization and uncover therapeutic opportunities to target this state.

dlvr.itLean, mean, breast cancer-fighting machineNature Reviews Cancer, Published online: 16 October 2026; doi:10.1038/s41568-026-00996-yObesity is a modifiable risk factor associated with increased tumour incidence and aggressiveness. Curtin et al. identify an oxylipin secreted by lean adipocytes that suppresses breast cancer progression.

dlvr.itMapping the functional dark proteome in cancer - Nature Reviews CancerThe dark proteome encompasses previously undiscovered and uncharacterized protein molecules derived from alternative genomic loci or altered RNA translation. In this Perspective, Prensner et al. describe the current understanding of the dark proteome and set out the critical questions that need to be addressed in the field to determine whether the dark proteome can fulfill its potential for clinical translation.

🚨 #PERSPECTIVE 🚨 The dark proteome comprises previously undiscovered proteins arising from alternative genomic loci or altered translation. Presner et al. review what we know, and what's needed to unlock its clinical potential.

dlvr.itThe urgent challenge of gastroesophageal cancer - Nature Reviews CancerGastric and oesophageal cancers caused more than 1 million deaths worldwide in 2024. In this Comment, Cancer Grand Challenges explain how they have launched two targeted challenges to address this unmet need, inviting global interdisciplinary teams to apply for up to US $34 million in funding from the Torrey Coast Foundation and Cancer Research UK and move the dial towards the prevention of gastroesophageal cancer.

Gastric and oesophageal cancers caused more than 1 million deaths worldwide in 2024. In this Comment, Cancer Grand Challenges explain how they have launched two targeted challenges to address this unmet need. #COMMENT

dlvr.itBoosting CAR T cell efficacy in cancer with metabolic insights from design to diet - Nature Reviews CancerAlthough chimeric antigen receptor (CAR) T cell therapy has advanced the treatment of many cancers, it is now apparent that metabolism is a major determinant of CAR T cell fitness, persistence and function. Here, Morgan, MacPherson and Lum examine how metabolism integrates with CAR T cell design, outline possible metabolic engineering solutions, and highlight opportunities to leverage diet to improve CAR T cell efficacy in people with haematological cancers.

🚨 #REVIEW 🚨 Morgan, MacPherson & Lum examine how metabolism integrates with CAR T cell design, outline metabolic engineering solutions & highlight opportunities to leverage diet to improve CAR T cell efficacy.

dlvr.itPsychosocial burden in cancer survivors - Nature Reviews CancerAs health systems struggle to provide follow-up care for the growing number of cancer survivors, the psychosocial consequences of a cancer diagnosis remain insufficiently recognized and addressed. In this Comment, Patricia Ganz explores how survivorship care can better address the long-term psychosocial needs of cancer survivors.

Some health systems struggle to provide follow-up care for the growing number of cancer survivors. In this #Comment, Ganz explores how survivorship can better address the long-term psychosocial needs of cancer survivors.

dlvr.itThe urgent challenge of gastroesophageal cancerNature Reviews Cancer, Published online: 09 October 2026; doi:10.1038/s41568-026-00990-4Gastric and oesophageal cancers caused more than 1 million deaths worldwide in 2024. In this Comment, Cancer Grand Challenges explain how they have launched two targeted challenges to address this unmet need, inviting global interdisciplinary teams to apply for up to US $34 million in funding from the Torrey Coast Foundation and Cancer Research UK and move the dial towards the prevention of gastroesophageal cancer.

dlvr.itMapping the functional dark proteome in cancerNature Reviews Cancer, Published online: 08 October 2026; doi:10.1038/s41568-026-00985-1The dark proteome encompasses previously undiscovered and uncharacterized protein molecules derived from alternative genomic loci or altered RNA translation. In this Perspective, Prensner et al. describe the current understanding of the dark proteome and set out the critical questions that need to be addressed in the field to determine whether the dark proteome can fulfill its potential for clinical translation.

dlvr.itBoosting CAR T cell efficacy in cancer with metabolic insights from design to dietNature Reviews Cancer, Published online: 07 October 2026; doi:10.1038/s41568-026-00984-2Although chimeric antigen receptor (CAR) T cell therapy has advanced the treatment of many cancers, it is now apparent that metabolism is a major determinant of CAR T cell fitness, persistence and function. Here, Morgan, MacPherson and Lum examine how metabolism integrates with CAR T cell design, outline possible metabolic engineering solutions, and highlight opportunities to leverage diet to improve CAR T cell efficacy in people with haematological cancers.

dlvr.itSupercentenarians’ superpower to suppress cancerNature Reviews Cancer, Published online: 02 October 2026; doi:10.1038/s41568-026-00989-xHashimoto et al. show that individuals who have lived to be 110 or older, known as supercentenarians, possess a high fraction of CD4+ cytotoxic T cells, which may contribute to the suppression of subclinical tumours.

dlvr.itEngineered models of metastasisNature Reviews Cancer, Published online: 02 October 2026; doi:10.1038/s41568-026-00987-zIn a recent study, Chramiec, Baldassarri, Öztürk et al. develop a vascularized human multi-tissue platform that captures organ-specific metastatic colonization, microenvironmental remodelling and tumour-cell adaptation, offering a configurable system for modelling metastatic progression.

dlvr.itPsychosocial burden in cancer survivorsNature Reviews Cancer, Published online: 01 October 2026; doi:10.1038/s41568-026-00986-0As health systems struggle to provide follow-up care for the growing number of cancer survivors, the psychosocial consequences of a cancer diagnosis remain insufficiently recognized and addressed. In this Comment, Patricia Ganz explores how survivorship care can better address the long-term psychosocial needs of cancer survivors.

dlvr.itShaping the future of early-onset colorectal cancer prevention - Nature Reviews CancerEarly-onset colorectal cancer is rising globally. This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.

#ROADMAP 🚨 Early-onset colorectal cancer is rising. This Roadmap explores current gaps in our understanding of risk factors and presents a conceptual framework for discovery + prevention. Plus, it's free to read! Please share!

dlvr.itReplication stress in cancer: origins, consequences and therapeutic opportunities - Nature Reviews CancerReplication stress drives genomic instability, tumour evolution and therapeutic adaptation, yet also creates exploitable vulnerabilities. In this Review, Chen and Zou discuss how chronic replication stress shapes cancer biology and how emerging therapies are targeting the pathways that enable tumour cells to survive it.

🚨 #REVIEW 🚨 Chen and Zou discuss how chronic replication stress shapes cancer biology and how emerging therapies are targeting the pathways that enable tumour cells to survive it. 👇 📖

dlvr.itMaking breast cancer innovation deliver for every woman - Nature Reviews CancerDespite remarkable advances in our understanding of breast cancer biology and in the diagnosis and treatment of the disease, outcomes remain deeply influenced by where people live, how health systems function and whether care pathways are effectively coordinated. In this Comment, Miriam Mutebi outlines how we can translate innovation into equitable patient benefits.

#Comment 🚨 How can we ensure that breakthroughs in breast cancer research improve outcomes for every woman? Miriam Mutebi examines the challenges and opportunities in translating innovation into equitable patient benefit. 📖⬇️

dlvr.itViral mimicry escape as a necessary feature of malignant transformation - Nature Reviews CancerViral mimicry is the activation of antiviral immune responses by endogenous nucleic acids that have accumulated in the cytosol. In this Review, Chen et al. highlight how cancer-associated epigenetic and transcriptional dysregulation promotes the generation of immunogenic nucleic acids, which can limit tumour progression. They further outline the mechanisms tumours use to suppress these responses, and the evidence that escape from viral mimicry is central to tumour evolution and a potential target for therapy.

Review🚨 Viral mimicry activates antiviral immune responses through endogenous nucleic acids in the cytosol. Chen et al. discuss how tumours suppress these responses and why escape from #ViralMimicry may be a key feature of tumour evolution. 📖⬇️

#Editorial 🎉Time to celebrate 25 years of #NatureReviewsCancer🎉 On this milestone we contemplate how our view of cancer has changed over the past 25 years and speculate on what the future holds.🥳 Thanks to our authors & readers who made this possible! 📖⬇️ http://dlvr.it/TVdJXj

dlvr.itReplication stress in cancer: origins, consequences and therapeutic opportunitiesNature Reviews Cancer, Published online: 22 September 2026; doi:10.1038/s41568-026-00979-zReplication stress drives genomic instability, tumour evolution and therapeutic adaptation, yet also creates exploitable vulnerabilities. In this Review, Chen and Zou discuss how chronic replication stress shapes cancer biology and how emerging therapies are targeting the pathways that enable tumour cells to survive it.

22 Sept

dlvr.itA guide to understanding tumour evolution through the lens of population genetics - Nature Reviews CancerPopulation genetics provides a quantitative framework for interpreting cancer genomes as records of tumour evolution. This Review outlines how models of mutation, selection and drift enable inference of tumour dynamics from sequencing data, distinguish genetic and non-genetic processes, and support extraction of evolutionary trajectories beyond pattern-based statistical genomics.

22 Sept

#Review 🚨 How can #PopulationGenetics help decode tumour evolution? This Review discusses how mutation, selection and drift shape cancer genomes and how evolutionary models can reveal tumour dynamics and trajectories from sequencing data. 📖⬇️

dlvr.itFrom blunt-force treatment to precision: 25 years of transformation in cancer researchNature Reviews Cancer, Published online: 22 September 2026; doi:10.1038/s41568-026-00980-6This Editorial marks the 25th anniversary of Nature Reviews Cancer. On this milestone we contemplate how our view of cancer has changed over the past 25 years and speculate on what the future holds.

22 Sept

21 Sept

#ViewPoint 🎉 Celebrating 25 years of NRC! Six leaders in cancer research reflect on the ideas that transformed their field, those that fell short of expectations and the challenges that remain. 📖👇 http://dlvr.it/TVZmk1

dlvr.itA single-cell lens into the co-evolution of genotypes and phenotypes in cancer - Nature Reviews CancerIn this Review, Izzo et al. discuss how single-cell multimodal sequencing enables genotype–phenotype mapping and, when combined with phylogenetic reconstruction, provide insights into clonal evolution, cell state plasticity, and cancer progression, revealing mutant-specific vulnerabilities and offering a framework to study somatic evolution across pre-malignant and malignant human tissues.

18 Sept

#Review🚨 Read how genotype and phenotype co-evolve during cancer progression with insights from single-cell multimodal technologies and phylogenetic approaches, revealing vulnerabilities in mutant clones. @landau.bsky.social 📖👇

dlvr.itNeutrophils in cancer - Nature Reviews CancerNeutrophils exhibit context-dependent pro-tumour and antitumour functions in cancer. In this Review, Diehl, Basto et al. examine neutrophil roles in tumour progression and metastasis, drawing parallels with non-cancer contexts and highlight emerging strategies to therapeutically target and reprogramme neutrophil biology in cancer.

17 Sept

#Review🚨 #Neutrophils can impact tumor growth. This Review explores their role in tumor progression and #metastasis, compares it to other biological contexts, and discusses new strategies for targeting neutrophil biology in cancer. @stanfordpress.bsky.social 📖👇

16 Sept

🚨 Early-onset colorectal cancer is on the rise globally. This #Roadmap highlights knowledge gaps, proposes a model for risk factor discovery, and emphasizes the importance of patient engagement and transdisciplinary science in combating this trend. 📖⬇️

dlvr.itOrigins and consequences of oncogenic 3D chromatin remodelling - Nature Reviews CancerIn this Review, Franceschini and colleagues discuss how remodelling of the 3D structure of chromatin in cancer is both a cause and a consequence of genetic and epigenetic alterations and highlight how chromatin 3D conformation might be exploited for diagnosis and therapy.

15 Sept

Review🚨 Ciriello, Oricchio &Co discuss how remodelling of the 3D structure of #chromatin in cancer is both a cause and a consequence of genetic and epigenetic alterations and highlight how chromatin 3D conformation might be exploited for diagnosis and therapy. 📖⬇️

dlvr.itViral mimicry escape as a necessary feature of malignant transformationNature Reviews Cancer, Published online: 15 September 2026; doi:10.1038/s41568-026-00977-1Viral mimicry is the activation of antiviral immune responses by endogenous nucleic acids that have accumulated in the cytosol. In this Review, Chen et al. highlight how cancer-associated epigenetic and transcriptional dysregulation promotes the generation of immunogenic nucleic acids, which can limit tumour progression. They further outline the mechanisms tumours use to suppress these responses, and the evidence that escape from viral mimicry is central to tumour evolution and a potential target for therapy.

15 Sept

dlvr.itEarly evidence of the carcinogenic effects of e-cigarette use - Nature Reviews CancerIn this Journal Club, Yolanda Chirino and Estefany Medina-Reyes discuss a study that used mechanistic markers of carcinogenesis to provide early evidence of the potential cancer risks associated with e-cigarette exposure.

14 Sept

#JournalClub 🚨 Yolanda Chirino and Estefany Medina-Reyes discuss a study linking e-cigarette exposure to mechanistic markers of carcinogenesis and the implications for cancer prevention research. 📖⬇️

dlvr.itMaking breast cancer innovation deliver for every womanNature Reviews Cancer, Published online: 11 September 2026; doi:10.1038/s41568-026-00982-4Despite remarkable advances in our understanding of breast cancer biology and in the diagnosis and treatment of the disease, outcomes remain deeply influenced by where people live, how health systems function and whether care pathways are effectively coordinated. In this Comment, Miriam Mutebi outlines how we can translate innovation into equitable patient benefits.

11 Sept

11 Sept

#Viewpoint 🎉 Celebrating #25yrs! Read insights from six emerging cancer researcherson the #future of their field, as they challenge traditions and propose innovative approaches for the next 25 years. 📖👇 http://dlvr.it/TVRFsV

dlvr.itExpanding the reach of menin inhibitors - Nature Reviews CancerMegakaryocytes contribute substantially to the pathogenesis of myeloproliferative neoplasms (MPNs), but therapeutic strategies targeting this lineage are lacking. Wen, Cotton et al. demonstrate that menin inhibition impairs megakaryocyte differentiation, suppresses myelofibrosis and improves disease features across preclinical MPN models.

10 Sept

#ResearchHighlight🚨Expanding the reach of #menin inhibitors A study shows that menin inhibition impairs #megakaryocyte differentiation, suppresses myelofibrosis and improves disease features across preclinical models of myeloproliferative neoplasms (#MPN). 📖👇

dlvr.itA guide to understanding tumour evolution through the lens of population geneticsNature Reviews Cancer, Published online: 09 September 2026; doi:10.1038/s41568-026-00973-5Population genetics provides a quantitative framework for interpreting cancer genomes as records of tumour evolution. This Review outlines how models of mutation, selection and drift enable inference of tumour dynamics from sequencing data, distinguish genetic and non-genetic processes, and support extraction of evolutionary trajectories beyond pattern-based statistical genomics.

9 Sept

dlvr.itThe long return on discovery science in cancer therapeutics - Nature Reviews CancerMany advances in cancer treatment depend on discoveries made decades earlier. In this Comment, Murphy et al. discuss the histories of EGFR, HER2, CDK4/6 and RAS, highlighting how long translation can take and how clinical benefit can continue to accumulate as more effective drugs are developed, used in earlier disease settings and combined with existing treatments.

9 Sept

#Comment🚨 Swanton&Co @charlesswanton.bsky.social highlight the histories of EGFR, HER2, CDK4/6 and RAS, and discusses how sustained investment in discovery science continues to generate clinical benefit through new drugs, indications and treatment combinations. 📖⬇️

dlvr.itA single-cell lens into the co-evolution of genotypes and phenotypes in cancerNature Reviews Cancer, Published online: 08 September 2026; doi:10.1038/s41568-026-00970-8In this Review, Izzo et al. discuss how single-cell multimodal sequencing enables genotype–phenotype mapping and, when combined with phylogenetic reconstruction, provide insights into clonal evolution, cell state plasticity, and cancer progression, revealing mutant-specific vulnerabilities and offering a framework to study somatic evolution across pre-malignant and malignant human tissues.

8 Sept

dlvr.itReflecting on 25 years of cancer research: transformative advances and unmet expectationsNature Reviews Cancer, Published online: 08 September 2026; doi:10.1038/s41568-026-00974-4To mark the 25th anniversary of Nature Reviews Cancer, six researchers reflect on the conceptual advances that have reshaped cancer research — from somatic mosaicism, functional genomics and cancer stem cells to tumour metabolism, precision oncology and artificial intelligence — and consider which ideas transformed the field, which fell short of expectations, and what challenges remain.

8 Sept

dlvr.itNeutrophils in cancerNature Reviews Cancer, Published online: 07 September 2026; doi:10.1038/s41568-026-00968-2Neutrophils exhibit context-dependent pro-tumour and antitumour functions in cancer. In this Review, Diehl, Basto et al. examine neutrophil roles in tumour progression and metastasis, drawing parallels with non-cancer contexts and highlight emerging strategies to therapeutically target and reprogramme neutrophil biology in cancer.

7 Sept

dlvr.itThe next 25 years of cancer research: emerging perspectives and prioritiesNature Reviews Cancer, Published online: 07 September 2026; doi:10.1038/s41568-026-00975-3To mark the 25th anniversary of Nature Reviews Cancer, six emerging cancer researchers share their perspectives on the future of the field, highlighting conceptual opportunities, challenging established paradigms and identifying the approaches they believe will drive progress in the field over the next 25 years.

7 Sept

dlvr.itExpanding the reach of menin inhibitorsNature Reviews Cancer, Published online: 02 September 2026; doi:10.1038/s41568-026-00981-5Megakaryocytes contribute substantially to the pathogenesis of myeloproliferative neoplasms (MPNs), but therapeutic strategies targeting this lineage are lacking. Wen, Cotton et al. demonstrate that menin inhibition impairs megakaryocyte differentiation, suppresses myelofibrosis and improves disease features across preclinical MPN models.

2 Sept

dlvr.itBrain barriers at the crossroads of glioma immune surveillance and immunotherapy response - Nature Reviews CancerImmunotherapy remains largely ineffective in gliomas despite success in other cancers. In this Review, Engelhardt and Platten outline how central nervous system immune privilege is enforced by specialized brain barriers that restrict T cell surveillance and discuss strategies to overcome these barriers to improve T cell-based immunotherapy for glioma.

28 Aug

#REVIEW🚨 Engelhardt @brittae.bsky.social& Platten @michael-platten.bsky.social outline how specialized brain barriers restrict T cell surveillance in the CNS and discuss strategies to overcome these barriers to improve T cell-based immunotherapy for #glioma. 📖👇

dlvr.itThe long return on discovery science in cancer therapeuticsNature Reviews Cancer, Published online: 28 August 2026; doi:10.1038/s41568-026-00978-0Many advances in cancer treatment depend on discoveries made decades earlier. In this Comment, Murphy et al. discuss the histories of EGFR, HER2, CDK4/6 and RAS, highlighting how long translation can take and how clinical benefit can continue to accumulate as more effective drugs are developed, used in earlier disease settings and combined with existing treatments.

28 Aug

dlvr.itShaping the future of early-onset colorectal cancer preventionNature Reviews Cancer, Published online: 26 August 2026; doi:10.1038/s41568-026-00965-5Early-onset colorectal cancer is rising globally. This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.

dlvr.itEpigenetic changes linked to cell replication connect ageing with cancer risk - Nature Reviews CancerIn this Journal Club, Sandra Romero-Cordoba discusses a study that identifies a replication-associated DNA methylation signature, termed CellDRIFT, providing evidence that epigenetic drift linked to cell division may contribute to oncogenic transformation.

#JournalClub🚨 Sandra Romero-Cordoba highlights evidence that a replication-associated DNA methylation signature, CellDRIFT, captures epigenetic changes linked to cell proliferation and may help explain how ageing increases cancer risk. 📖👇

dlvr.itEarly evidence of the carcinogenic effects of e-cigarette useNature Reviews Cancer, Published online: 26 August 2026; doi:10.1038/s41568-026-00976-2In this Journal Club, Yolanda Chirino and Estefany Medina-Reyes discuss a study that used mechanistic markers of carcinogenesis to provide early evidence of the potential cancer risks associated with e-cigarette exposure.