NC3Rs

Register now for our welfare webinar exploring refinements for laboratory Xenopus. 📅 26 November, 12.00 – 13.00 🙋🏻‍ For researchers, animal technicians and veterinarians 📜 Certificates of attendance available 👉 nc3rs.org.uk/events/welfa...

This year’s International 3Rs Prize recognises pioneering human-relevant approaches across immunotherapy, oncology and gene therapy, which enable the replacement of animals and generate new insights into human disease. Read about the winning and highly commended papers: nc3rs.org.uk/news/pioneer...

The International Coalition of Medicines Regulatory Authorities (ICMRA) has published a statement signalling international commitment to the replacement of animal testing for human medicines, on behalf of over 40 national medicines regulators. Read ICMRA’s statement: icmra.info/drupal/en/st...

New NC3Rs database launched to help identify opportunities to use alternative methods and approaches in regulatory safety assessment: nc3rs.org.uk/news/support... Consultation open until 22 January 2027: nc3rs.org.uk/3rs-resource...

Our websites are currently down for essential maintenance and will be back online soon. If you have any questions or queries while our sites are down please email: webmaster@nc3rs.org.uk. We will update you when the maintenance is complete.

The Experimental Design Assistant (EDA) application remains live: eda.nc3rs.org.uk/eda/login/auth but please note some of the support features will not work as these are hosted on the EDA website.

Register now for our welfare webinar exploring the role of anaesthesia and analgesia as key refinements for fish used in research. 📅 22 October, 12.30 – 13.30.  🙋🏻‍ For researchers, animal technicians and veterinarians 📜 Certificates of attendance available 👉 nc3rs.org.uk/events/welfa...

In the latest edition of 'Xenopus protocols' Esther Pearl (NC3Rs Experimental Design Programme Manager) has contributed to two chapters alongside experts from the European Xenopus Resource Centre, covering key refinements alongside breeding and colony management to reduce the number of frogs used.

Chapter 1 outlines appropriate housing, husbandry and health monitoring for laboratory Xenopus, including environmental enrichment, identifying individual frogs and anaesthetic doses for different life stages: link.springer.com/protocol/10....

The results of our worldwide stakeholder survey, published in Biologicals, highlights support for non-animal methods in quality control and batch release of biologics, alongside the role of WHO and regulators to ensure alternatives are available and supported for adoption: doi.org/10.1016/j.bi...

Register now for our upcoming welfare webinar on fish skin swabbing for refined DNA sampling. 📅 24 September, 12.00 – 13.00 🧑‍🔬 For researchers, animal technicians and veterinarians 📜 Certificates of attendance available 👉 nc3rs.org.uk/events/welfa...

Adriana Buskin has fully replaced the use of rats in her lab at @newcastleuni.bsky.social using an animal-free prostate organoid developed with NC3Rs funding. Read her new publication in @cp-cellrepmethods.bsky.social: www.cell.com/cell-reports... Watch Adriana's video to learn more 👇

Biostatistician Penny Reynolds and NC3Rs Programme Manager @drejpearl.bsky.social discuss transparent reporting of animal research in the 60th anniversary edition of the Laboratory Animals Journal, exploring the link between the 3Rs, scientific quality and animal welfare: doi.org/10.1177/0023...

Today we are pleased to launch the DRIVER recommendations, a new framework designed to improve the quality, reliability and reproducibility of research using in vitro models: nc3rs.org.uk/news/driver-...

Developed in partnership with experts from around the world, the recommendations focus on the full experimental process for in vitro studies, from the design through to data analysis and reporting. Find out more about their development: nc3rs.org.uk/3rs-resource...

Three months on from launching SIRF-UP, an @eu-sabv.bsky.social initiative to support ethical review bodies assess sex inclusivity in animal research, a new publication renews our call to get involved, share your experiences and use the Sex Inclusive Research Framework. 👉 doi.org/10.1177/0023...

Register now for the sixth webinar in our Technology Partn3Ring series on new approach methodologies (NAMs) to explore collaboration opportunities with the speakers. Wednesday 15 July 14.00 – 15.15 BST Register 👉 events.teams.microsoft.com/event/ed2a34...

Speakers will showcase technologies with the potential to replace animal use, including a genetically engineered lung cancer model, a zebrafish multi-omics assay for developmental toxicity, lab-grown musculoskeletal tissues, and iPSC-derived cardiac and multi-tissue safety screening assays.

NAMs Technology Partn3Ring webinar: Session 5 17 June, 14.00 BST Explore in silico modelling, bioengineered bone organoids, airway-on-chip, and human cardiac tissue models for preclinical drug development and toxicity assessment. Register 👉 events.teams.microsoft.com/event/7b230e...