Nephrology Journal Club

nephjc.comNephJC 2026 Fall Pledge Drive — NephJCHelp keep NephJC a vital, original, and unbiased source of medical education.

8 Sept

#NephJC runs on community magic ✨ We choose to stay free and independent and give back to our community for 12yrs 🩵 If our blogs, podcasts, or visuals have helped you, your donation keeps us going - and might get you into the coolest #KidneyWk party www.nephjc.com/news/2026/9/...

nephjc.comKidney Week in Denver: Day 3 — NephJCDay 3 : yet another IgA trial, and we are back with some flozin news: in ADPKD, their effect on hemoglobin, and on BP (with finerenone)

#kidneywk Day 3 of simultaneous publications covered by #nephjc Until the next time 👋 ✍️ @nephroseeker.medsky.social @dramiliflores.bsky.social @nephromommy-akshu.bsky.social @hswapnil.medsky.social www.nephjc.com/news/denver-...

nephjc.comKidney Week in Denver: Day 2 — NephJCDay 2 was less exciting: we cover 1 IgA trial (Ravulizumab) along with another calcimimetic, and a pentoxifylline meta-analysis.

#kidneywk

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social

The second day edition of the #KidneyWk highlights is up www.nephjc.com/news/denver-... #NephJC

nephjc.comKidney Week in Denver: Day 1 — NephJCDay of Kidney Week 2026. The NephJC crew discusses 6 studies, including some blockbustr IgA news.

Day one of #KidneyWk is in the books. Feeling the #FOMO yet? Check out the late breaking /simultaneous pub summaries by @hswapnil.medsky.social @nephroseeker.medsky.social @dramiliflores.bsky.social @nephromommy-akshu.bsky.social www.nephjc.com/news/2026/10...

🚨 One of the most anticipated nights of #KidneyWk is almost here! Come celebrate 15 years of #NephJC Nights with friends, colleagues, food, drinks, and plenty of kidney conversations. 📍 Denver Press Club 📅 Friday, October 23 Good company 💙 www.nephjc.com/news/...

🚨 Double the runs. Double the fun #NephJC is bringing TWO NephRuns to #KidneyWk! 🏃 Friday NephRun 🏃 Saturday NephRun 5K Start your day with fresh air, great company, and the best community in nephrology. See you at the starting line! 👇More details www.nephjc.com/news/...

🩵📬 Don't miss a single #NephJC moment during #KidneyWk! Subscribe to our newsletter and get the latest events, article summaries, and kidney goodness delivered straight to your inbox ✨ www.nephjc.com/newsl...

🩵📧 Kidney Week moves fast... let us keep you in the loop! Subscribe to the #NephJC newsletter for event updates, highlights, and all the nephrology fun headed your way during #KidneyWk www.nephjc.com/newsl...

nephjc.comKidney Week Run(s) at Denver — NephJCReady to run at kidney Week? Here are the details

🏃‍➡️🏃‍♀️‍➡️Neph run(s) during #KidneyWk 👇 Read more about it #NephJC www.nephjc.com/news/nephrun...

nephjc.com2026 NephJC Night in Denver — NephJCOn FRIDAY night, October 23rd, NephJC will host another legendary NephJC Night during ASN Kidney Week

Join the coolest kidney party of #KidneyWk! 🩵 Just 6 days to go! Grab your ticket here: www.nephjc.com/news/2026/9/... 🙏Thank you to everyone who has donated already. Your support keeps #NephJC moving forward

1/10 #NephJC #TenPostNephJC. #NephTwitter Patient outcomes are better with transplant vs dialysis. Is this always true? What about high-risk donors (expanded criteria donor-ECD) or recipients (elderly with DM or CVD)? Read the article 👇 link to article on pubmed.ncbi.nlm.nih.gov/42759976/

nephjc.comCan Dialysis Outshine Transplant in the Elderly? — NephJCThis week, we will discuss whether decreased donor transplantation improves mortality in all patients. In this target trial emulation standard donor, extended donor, donation after brain death and don...

9/10 I want more info: link to the NephJC blog and VAs www.nephjc.com/news/transpl... Urvashi SM Assad Daniel

10/10 Final thoughts: Transplant benefits are certainly not universal and require careful conversations about individualized benefits. Up next- ASN #KidneyWeek26 in Denver, CO. Hope to see you there! Check out NephJC.com, become a donor and for party details.

nephjc.comNephJC

7/10 Question 2 #NephJC #Nephsky Should older/sicker patients risk transplant? These are the individualized conversations that are needed. Although older pts receiving poorer kidneys (ECD) didn’t show mortality benefit, QoL is still an important consideration.

8/10 #NephJC Consensus: In most cases, DDKT can improve survival compared to continued dialysis. Not all donor kidneys are created equal (SCD, ECD, DCD, DBD). Discussion of recipient and donor quality should be undertaken during transplant evaluation, as well of goals of care

5/10 A picture paints 1000 words As the donor & the recipient “quality” ⬇️, so do benefits. Although higher quality kidneys (SCD) did better in worse recipients (those >75, DM+, CVD+), should they have access to SCD kidneys if overall survival is ⬇️ than younger candidates?

6/10 Question 1 #NephJC #Nephsky So, should we transplant all ESRD cases? It depends. SCD kidneys improved mortality in all studied groups. However, SCD kidneys may not be readily available for all waitlisted patients. Worthy of discussion with older, sicker patients.

3/10 1 post methods -SCD, ECD, donor after brain death (DBD), donor after CV death (DCD) -4 transplant groups: SCD/DBD, SCD/DCD, ECD/DBD, ECD/DCD were compared in 4 patient groups: All, DM+, CVD+, neither DM/CVD The 16 trials generated 1,491,537 person-trials

4/10 1 post results 64.1% ♂️, mean age 55 years; median dialysis vintage-238 days. Comorbidities include DM (26%), CVD (25%). For pts > 75 ECD/DCD kidneys did not show a mortality benefit, however, numbers of pts in this category were small.

2/10 What was the study? 🎯Target trial emulation: using collected data to mimic a randomized trial 🇪🇺 ERA registry: 2000-2019 ✅Included: >20 years of age, waitlisted for receiving a kidney transplant 🧮60 sequential trial emulations

nephjc.comTARGET trial: El Resumen Visual — NephJC¿El trasplante renal de donante fallecido siempre ofrece mayores ventajas que continuar en diálisis?

TARGET trial: El Resumen Visual Gracias @danyrcal.bsky.social y @dramiliflores.bsky.social www.nephjc.com/news/target2

nephjc.comTARGET TRIAL: The Visual Abstract — NephJCCan a deceased donor kidney transplant offer better survival than continuing dialysis in elderly?

Check out the VA by @danyrcal Do older, sicker patients benefit from kidney transplantation? This is a nuanced "it depends" answer that is worthy of discussion. #NephSky #NephJC www.nephjc.com/news/targetva

This week we are looking at a target trial emulation on transplantation. Do older patients benefit from kidney transplant? What if the donation is after: CV death or brain death? What if the donor is a standard (SCD) or extended (ECD) criteria donor? #NephSky #NephJC www.nephjc.com/news/transpl...

nephjc.comNephJC 2026 Fall Pledge Drive — NephJCHelp keep NephJC a vital, original, and unbiased source of medical education.

12 years of #NephJC. Countless papers discussed, ideas challenged, and friendships made. 🩵No paywalls. No pharma funding, just a community that believes in free, independent nephrology education. 🌟We need your help to keep it going. Please donate www.nephjc.com/news/2026/9/...

nephjc.comRaising sodium: can tolvaptan rival 3% hypertonic saline? — NephJCTesting Tolvaptan versus 3% saline and the rate of rise of serum sodium in healthy volunteers.

Can tolvaptan keep up with 3% saline? This within-subject study in healthy volunteers delivered a surprising answer - and a few eyebrow-raising physiology twist. Dive in #NephJC ✍️ by @drsaivani.bsky.social www.nephjc.com/news/tolvapt...

1/10 #NephJC #TenPosts #NephSly 🫘💊 START your steroids! A question we ask constantly but adult RCT data rarely answers after remission in steroid-sensitive MCD/FSGS, how long should the prednisolone taper actually be? 🧵 www.sciencedirect.com/science/arti...

10/10 START questions the default "longer = better" steroid assumption. A 2-month taper looks to be a reasonable place to START post-remission for many steroid-sensitive patients. However, simplicity and a one-size-fits-all strategy, is not an option.

11/10 ➡️Up next on 10/13: Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation | The BMJ www.bmj.com/content/394/... Join us www.nephjc.com/

nephjc.comNephJC

8/10 ⚠️ #NephJC Consensus 💡Underpowered (94/114 target, ~75% power), open-label, 2 center trial, wide margin (CI compatible w/ ~14 extra relapses/100 pts short-course), and FSGS trended toward favoring the longer taper underpowered subgroup 💡Hypothesis-generating only

nephjc.comWhy Can’t I Quit You: Steroid Tapering in Adults with Podocytopathies (START) — NephJCThis week, we will discuss the best schedule for tapering steroids in adult patients with podocytopathies (MCD/FSGS).

9/10 I want more info: nephjc.com/news/startst... www.nephjc.com/news/starttr... www.nephjc.com/news/startsp... Andreea Manolea, Farah Wehbe, David White

6/10 Question 1 #NephJC #Nephsky or #NephTwitter Q: Should we stop steroids quickly in all podocytopathies? A: Probably not, but this gives us evidence that we should explore this further in larger trial, as less steroids has less AE exposure, but also without more relapses

7/10 Question 2 #NephJC #NephTwitter Q: Can MCD & FSGS receive similar steroid taper regimens? A: Probably not! We need a more adequately powered trial to answer this, especially with FSGS which remains more treatment resistant & steroid resistance may be disease defining

4/10 One post results ✅ Primary outcome: 12-mo relapse-free remission (ITT): 63.3% short vs 57.8% standard ✅Risk diff +5.5%, lower CI −14.3% clears the −25% margin (P=0.001) ✅Per-protocol analysis confirmed it too

5/10 A Picture is worth 1000 words 💉 The payoff: cumulative prednisolone roughly halved on the short course 1750mg vs 3430mg and as the KM graph shows ♻️Relapse free survival was essentially the same ⚡AEs were also less in short course arm

2/10 What did I miss? 📋 Open-label noninferiority RCT, 2 centers in India (2021–2023) 💊Adults with biopsy-proven MCD or FSGS who hit remission (proteinuria <0.5g/d) on prednisolone were randomized to a 2-month vs 4-month taper

3/10 One post methods 👥 118 screened → 94 randomized (49 short-course, 45 standard) after hitting remission. 👶Young cohort (mean age 32), MCD/FSGS almost evenly split, ~55% treatment-naive ‼️Noninferiority margin −25% points reflecting how sparse adult data on steroid taper duration

Steroids are useful (and have bad side effects) in patients with podocytopathies. Starting is easy, but stopping can be challenging. Are longer courses of steroids better for longer remissions? How quickly do you taper? 🐇🐢 #NephSky #NephJC www.nephjc.com/news/startsteroidtaper

nephjc.comSTART: El Resumen Visual — NephJC¿Podemos reducir el uso de esteroides tras la remisión?

El Resumen Visual, gracias @dramiliflores.bsky.social #NephSky #NephJC ¿Cuánto debe durar la reducción gradual de esteroides tras la remisión de una podocitopatía? www.nephjc.com/news/startspanish

nephjc.comSTART: The Visual Abstract — NephJCCan steroid tapering be shorter after remission in adults with sensitive podocytopathy?

Hey #NephJC 👋 Checkout the VA by @divyaveerssneph.bsky.social This week we're looking at steroid weaning strategies in adults with podocytopathies (MCD/FSGS). 💊Steroids: easy to start🟢 but hard to stop 🛑. #NephSky www.nephjc.com/news/starttrial

nephjc.comNephJC on LinkedIn — NephJCNephJC is now more than twelve years old- and it’s amazing to see how far a simple idea has grown. We started with a handful of nephrologists on Twitter (yeah, we still call it that) choosing a paper ...

15 Sept

📣Hey #NephSky We just passed 5000 #NephJC Newsletter subscribers Will you be 5001? Also, we can now be found at LinkedIN. So, if you are tired of "the bad place", but don't want to miss the latest, you can follow us there as well! www.nephjc.com/news/nephjc-on-linkedin

Nephrology Journal Club reposted

Swapnil Hiremath 🍁🇨🇦

@hswapnil.medsky.social

13 Sept

You want a ticket to the hottest event of #KidneyWk? www.nephjc.com/news/2026/9/... Consider a donation to the fall #NephJC pledge drive

nephjc.com2026 NephJC Night in Denver — NephJCOn FRIDAY night, October 23rd, NephJC will host another legendary NephJC Night during ASN Kidney Week

Nephrology Journal Club@nephjc.bsky.social

nephjc.comNephJC 2026 Fall Pledge Drive — NephJCHelp keep NephJC a vital, original, and unbiased source of medical education.

nephjc.com2026 NephJC Night in Denver — NephJCOn FRIDAY night, October 23rd, NephJC will host another legendary NephJC Night during ASN Kidney Week

14 Sept

⏳ Just a bit over one month until #KidneyWk And yes... the legendary #NephJC party is happening again 🎉 🩵Join us, meet the crew, and meet people from across the world 👇Grab your ticket and come be part of the magic www.nephjc.com/news/2026/9/...

Nephrology Journal Club reposted

Swapnil Hiremath 🍁🇨🇦

@hswapnil.medsky.social

14 Sept

recording another episode of @freelyfiltered.bsky.social with special guests @jaykoyner.bsky.social and Rahul Ganatra of @thecurbsiders.bsky.social @kidneyboy.bsky.social @sophia-kidney.bsky.social and Vipin Varghese