Olivia Coleman

Olivia Coleman

@ocoleman.bsky.social

Young Investigator @TU_Muenchen curious about the intestinal microbiota, mucus and colorectal cancer. Travel lover, dog lover, rum lover, proud mum and wife.

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Olivia Coleman
@ocoleman.bsky.social

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences www.nature.com/articles/s42...

nature.comATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature MetabolismThe transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...

Olivia Coleman reposted

Nature Metabolism
@natmetabolism.nature.com

RESEARCH | @ocoleman.bsky.social , Sorbie, Haller et al. (TUM) ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪

bit.lyATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature MetabolismThe transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.
Olivia Coleman
@ocoleman.bsky.social

I recently had the pleasure of a short stay at the University of Gothenburg, hosted by Elisabeth Nyström. Many thanks to Liz and everyone in the Mucin Biology groups for the warm welcome and stimulating scientific exchange. Looking forward to continuing our collaboration! #mucusmatters

Olivia Coleman reposted

Alexander Bartelt
@barteltlab.bsky.social

@ocoleman.bsky.social way to go!

Technische Universität München@tum.de

Researchers identified a #cellularmechanism that alters the #gutmicrobiome in a way that promotes #cancer. The study could demonstrate the increased formation of long-chain #fattyacids – the preferred food of certain cancer-promoting #bacteria: go.tum.de/864170 📷A.Eckert

go.tum.deHow chronic cellular stress alters the gut microbiomeTUM researchers have identified a cellular mechanism through which cancer-promoting bacteria in the gut can multiply and adapt the gut microbiome.

Olivia Coleman reposted

Lydia Lynch
@lydialynch.bsky.social

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...

nature.comThe source of dietary fat influences anti-tumour immunity in obese mice - Nature MetabolismThis study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
Olivia Coleman
@ocoleman.bsky.social

Happy to share our latest paper showing that intestinal inflammation (IL10-/-) + an UPRER diva protein (ATF6) = a perfect storm for colon cancer: Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. academic.oup.com/ecco-jcc/art...

academic.oup.comSusceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancerAbstractBackground and aims. Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated c

Olivia Coleman reposted

George Birchenough
@gobletcellguy.bsky.social

Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎

Journal of Experimental Medicine@jem.org

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

Olivia Coleman
@ocoleman.bsky.social

It‘s been a pleasure to host @mucusman.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Two days filled with productive and fun #gobletcell exchanges and a fantastic talk on #mucus #autphagy #erstress and #antibiotics. Thanks for making the trip Shai! #mucusmatters

Olivia Coleman
@ocoleman.bsky.social

Better late than never...finally made the move to #bluesky! I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum

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