Pagès lab (@pageslab.bsky.social)

Pagès lab

@pageslab.bsky.social

DNA damage and genome instability group Cancer Research Center of Marseille. #DNAdamage, #TranslesionSynthesis, #HomologousRecombination, in bacteria & yeast

546 followers 191 following9 posts

Pagès lab

@pageslab.bsky.social

14 Nov 2025

Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!

Pagès lab

@pageslab.bsky.social

5 Nov 2025

Amazing view from the 24th floor of the Sorbonne tower at the 7th German-French DNA Repair Meeting! Excited to give my talk tomorrow!

Pagès lab

@pageslab.bsky.social

12 Sept 2025

New paper out! We show that RecBC remodels single-stranded DNA gaps to protect them from ExoI (sbcB) 3′-5′ exonuclease degradation during replication of damaged DNA. doi.org/10.1073/pnas...

doi.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Pagès lab

@pageslab.bsky.social

12 Sept 2025

open access version here: hal.science/hal-05250217

hal.scienceThe RecBC complex protects single-stranded DNA gaps during lesion bypassFollowing encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication...

Pagès lab reposted

CNRS Biologie

@cnrsbiologie.bsky.social

11 Apr 2025

#RésultatScientifique 🔎 Découvrez la dernière publication de Vincent Pagès et de ses collaborateurs ! 🤝 @cnrs-dr12.bsky.social @insermpacacorse.bsky.social @univ-amu.fr @paoli-calmettes.bsky.social @pageslab.bsky.social @crcm.bsky.social 👉 @narjournal.bsky.social buff.ly/rVeGV9B

Pagès lab

@pageslab.bsky.social

24 Mar 2025

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/...

Pagès lab

@pageslab.bsky.social

24 Mar 2025

Our key findings: -DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork. -Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity. -Gap extension by Exo1 nuclease favors DA and reduces TLS

Pagès lab

@pageslab.bsky.social

25 Feb 2025

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @joeloparo.bsky.social uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis. https://buff.ly/3Xbgjxd

Pagès lab

@pageslab.bsky.social

17 Dec 2024

Recruiting a postdoc to work on our yeast project

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