Pascal Grumbach

Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.

This paper was part of my medical doctoral thesis. I would like to especially thank @juergendukart.bsky.social for the excellent supervision and all co-authors for their valuable support: @leoschilbach.bsky.social @sbe.bsky.social @sofievalk.bsky.social

Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.

3) Administration of NMDA-antagonist ketamine in healthy controls resembled functional alterations and neurochemical co-localization profiles observed in autism. Thus, pharmacological modulation of the excitation/inhibition in healthy individuals leads to similar brain patterns as seen in autism.

Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.

1) Individuals with autism showed consistent local functional activity decreases compared to typically developed controls across ABIDE1/2, especially in default mode network regions.