Patrick Deelen

@robertwarmerdam.bsky.social

29 Aug

Combining science and hobby. I designed this DNA whiteboard marker holder for my desk at the UMCG Genetics department. Free model: www.printables.com/model/182665... #3Dprinting #DNA #genetics

Patrick Deelen reposted

Robert Warmerdam

6 Feb

🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

Downstreamer is now available: www.nature.com/articles/s41... We used 57 tissue specific gene expression networks to identify key genes of common diseases. 78% of these key genes are located outside of GWAS loci. 1/4

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Height key genes are enriched for growth abnormality genes, including many genes known causing Ehlers–Danlos or osteogenesis imperfecta. We suspect that the other height key genes could be interesting targets when interpreting variants of unknown significance in patients with these diseases. 3/4

The tissue specific networks and the Downstreamer software are available at: github.com/molgenis/sys... Thank you Olivier Bakker, @anniquec.bsky.social, Lude Franke and many others for a great collaboration. 4/4