NIH Pragmatic Trials Collaboratory

🌱 Hello, Bluesky! We are the NIH Pragmatic Trials Collaboratory. Our community of researchers is advancing the design, conduct, and dissemination of pragmatic clinical trials by integrating high-quality #pragmatictrials into routine patient care. Learn more at rethinkingclinicaltrials.org.

📣 We have results! In this week's PCT Grand Rounds, Margaret Kuklinski of the University of Washington and Stacy Sterling of @kaiser-permanente.bsky.social will present successes, challenges, and lessons learned from the Guiding Good Choices for Health trial. Join us! 🔗 du.ke/pctnews20261...

📣 In this week's PCT Grand Rounds, Daniel Yazdi of UpDoc and Cedars-Sinai will present “Agentic AI in Cardiovascular Care Delivery: UpDoc’s Approach to ARPA-H ADVOCATE.” Join us! 🔗 du.ke/pctnews20261...

🎙️ NOW AVAILABLE: Episode 1 of our 4-part podcast series. Drawing on experience from the NIH Collaboratory Trials, experts will share the latest wisdom in designing pragmatic trials that are feasible and capable of producing actionable evidence. 🔗 duke.is/pctpod

📣 In this week's PCT Grand Rounds, Adrian Hernandez of @dcrinews.bsky.social and @dukemedschool.bsky.social will present “Catalyzing Change: How First-in-Patient Trials Can Fix U.S. Clinical Trials.” Join us! 🔗 du.ke/pctnews20261...

An analysis of data from the GRACE trial found a mediating role of pain catastrophizing between depression and pain outcomes in adults with sickle cell disease and chronic pain. #nihHEALinitiative Learn more ➡️ duke.is/pctnews20261...

“EHR-enabled strategies that emphasize patient-centered decision-making and education may reduce opioid exposure while maintaining patient-centered outcomes, reinforcing the ongoing need for patient education to address opioid-related harms,” said Dr. Andrea Cheville. ➡️ duke.is/pctnews20260...

In the OPTIMUM study, patients' prior experience with virtual doctor visits influenced their willingness to participate in a telehealth-delivered mindfulness program for chronic low back pain. Learn more ➡️ duke.is/pctnews20261...

📣 In this week's PCT Grand Rounds, Christoph Hornik of @dcrinews.bsky.social and Moulik Shah of Maxis AI will present “An End-to-End Agentic AI Platform to Automate Clinical Trials: A Proof-of-Concept and Evaluation Study.” Join us! 🔗 du.ke/pctnews20261...

In an article in Frontiers in Pain Research, the APA-SM team describes their approach to engaging patients, clinicians, and healthcare system administrators in codesigning a feasible, culturally relevant pain management program in rural settings. duke.is/pctnews20261...

📣 In this week's PCT Grand Rounds, Diana Higgins and Alicia Heapy of @yaleschoolofmed.bsky.social will present “Self-Directed Versus Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: Results From the COPES ExTRA Pragmatic Trial.” Join us! 🔗 du.ke/pctnews20261...

Join experienced investigators from the NIH Pragmatic Trials Collaboratory to learn essentials of dissemination and implementation in #pragmatictrials in our full-day workshop at @academyhealth's 19th Annual D&I Conference. #DIScience26 Register today! duke.is/pctnews20260...

In NOHARM, an NIH Collaboratory Trial newly published in @jamanetworkopen.com, a strategy to promote nondrug pain care after surgery reduced exposure to opioids without worsening pain interference, physical function, and other patient-reported outcomes. Learn more ➡️ duke.is/pctnews20260...

📣 In this week's PCT Grand Rounds, Corey Bills of @cumedicalschool.bsky.social will discuss the PACT-ARROW study, which uses a master protocol for trials of prevention and treatment of infected traumatic wounds in hospitalized patients in Ukraine. Join us! #pctGR 🔗 duke.is/pctnews20260...

📣 Don’t miss the new 4-part podcast series demystifying embedded pragmatic trial design from @pctcollaboratory.bsky.social. Episode 1 sets the stage with NCCIH Director Wendy Weber and NIH Collaboratory co-PIs Adrian Hernandez and Lesley Curtis. 🔗 Listen now: duke.is/pctpod

📣 In this week's PCT Grand Rounds, Corey Bills of @cumedicalschool.bsky.social will discuss the PACT-ARROW study, which uses a master protocol for trials of prevention and treatment of infected traumatic wounds in hospitalized patients in Ukraine. Join us! #pctGR 🔗 duke.is/pctnews20260...

The NIA IMPACT Collaboratory, a program advancing pragmatic trials of interventions for people living with #dementia and their care partners, is seeking applicants for its 2027 Health Care Systems Scholars Program. 9/25: Info webinar 🧑🏽‍💻 11/5: Letter of intent 📩 Learn more ➡️ duke.is/pctnews20260...

📣 In this week's PCT Grand Rounds, Erika Rangel of @harvardmed.bsky.social will present “The 4th Trimester Initiative: A Randomized Controlled Trial of Support for Childbearing Medical Trainees.” Join us! 🔗 du.ke/pctnews20260...

📣 In this week's PCT Grand Rounds, Ryan Zarychanski of @umanitoba.bsky.social will present “Embedded Trials in a Learning Health System: A Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery.” Join us! 🔗 du.ke/pctnews20260...

Access our complete collection of pragmatic trials learning modules, videos, tools, workshop materials, and the Rethinking Clinical Trials Grand Rounds archive through our training resources portal. Learn more ➡️ duke.is/training

Meeting People Where They Are: Strategies for Improving Rural Representation in Clinical Research through Pragmatic Clinical Trials - Travis Lovejoy, Natassja Pal, Joseph Ali et al. | 2026, The Journal of Rural Health onlinelibrary.wiley.com/doi/10.1111/...

In an analysis from the Nudge study, the per-patient cost of text message reminders suggests that medication adherence support via mobile messaging may be a low-cost solution for healthcare systems. Learn more ➡️ du.ke/pctnews20260...

ICYMI Registration is now open for our virtual workshop, "Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes." #biostatistics #pragmatictrials #clinicalresearch duke.is/2026-nih-vir...

Viewpoint discusses the challenges of implementing findings from pragmatic clinical trials in health care systems. https://ja.ma/4gvoewT

📣 In this week's PCT Grand Rounds, Haider Warraich of @arpa-h.bsky.social will present “Evaluating Clinical Agentic AI.” Join us! 🔗 duke.is/pctnews20260...

A new article from NOHARM, an NIH Collaboratory Trial, describes strategies and challenges for posttrial sustainment of pragmatic trial interventions. duke.is/pctnews20260...

How can clinical trials become more efficient without compromising rigor? Alison Huang and Derek Angus discuss JAMA+ Trials and opportunities to share innovations that reduce complexity and improve how trials are designed and conducted. Listen below.

The LungSMART team has proposed a framework for assessing the fit of custom large language models in public health interventions. The framework can guide assessments of an LLM’s performance before deployment into real-world practice. Learn more ➡️ duke.is/pctnews20260....

📣 In this week's PCT Grand Rounds, Eric Karl Oermann of NYU Langone Health and New York University will present “Off-Label Intelligence: Books, Language Models, and AI as a Medical Device.” Join us! 🔗 duke.is/pctnews20260...

In a new episode of the NIH Collaboratory Podcast, Alison Huang and Derek Angus consider the potential of JAMA+ Trials as a platform and a forum. 🔗 Listen and subscribe: duke.is/pctpod

ICYMI Registration is now open for our virtual workshop, "Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes." #biostatistics #pragmatictrials #clinicalresearch duke.is/2026-nih-vir...

📣 In this week's PCT Grand Rounds, Christopher Lindsell, Lloyd Michener, @justinbmoorephd.bsky.social, Boris Volkov, and Reuben Adatorwovor will present “Designing for Impact: Introducing Translational Design Studies.” Join us! 🔗 duke.is/pctnews20260...

We recently spoke with investigators Rachel Winer, Amanda Petrik, and Jasmin Tiro about the the STEP-2 pragmatic trial's partnership with community health centers and Medicaid health plans to expand access to #HPV self-testing for cervical cancer. duke.is/pctnews20260...

In a new article in JAMIA Open, investigators from the NIH Collaboratory Trials report on their experiences using computable phenotypes with real-world data in pragmatic trials. Learn more ➡️ duke.is/pctnews20260...

A secondary analysis from the INSPIRE trials found that an antibiotic stewardship program with automated prompts to deliver patient-specific risk information to clinicians reduced unnecessary use of extended-spectrum antibiotics in patients with cancer. duke.is/pctnews20260...

📣 In this week's PCT Grand Rounds, Sreek Vemulapalli of @dukehealth.bsky.social and Ricardo Henao of @duke-university.bsky.social will present “ADAPT-CEC: AI for Clinical Event Adjudication and Implications for Clinical Trials.” Join us! 🔗 duke.is/pctnews20260...

In a qualitative study, the APA-SM team gained insights from research partners in rural areas to refine the trial's smartphone-based intervention for self-management of chronic musculoskeletal pain. #ruralhealth #NIHHEALinitiative duke.is/pctnews20260...

Join @pctcollaboratory.bsky.social for a virtual workshop, “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes” on September 8 and 9. Learn more: duke.is/2026-nih-vir... #pragmatictrials

Pragmatic clinical trials require statistical methods that reflect the complexities of real-world research. This NIH Pragmatic Trials Collaboratory workshop explores key biostatistical considerations for generating rigorous evidence that can inform clinical care.

🎙️ In a new episode of the NIH Collaboratory Podcast, Steven George and Christine Goertz of @dukemedschool.bsky.social discuss slow recruitment mitigation strategies, one of the small group discussion topics at the Steering Committee meeting in April. 🔗 Listen and subscribe: duke.is/pctpod

📣 In this week's PCT Grand Rounds, Steven Z. George and @nickihastings.bsky.social of @dukemedschool.bsky.social will present results and reflections from the AIM-Back cluster randomized clinical trial. Join us! 🔗 duke.is/pctnews20260...

Join us for our 2026 virtual workshop, “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes” on September 8 and 9. Registration is free and open to the public. ➡️ Learn more: duke.is/2026-nih-vir... #biostatistics #pragmatictrials #clinicalresearch

📣 In this week's PCT Grand Rounds, Rachel Greenberg and Danny Benjamin of @duke-university.bsky.social will present “The Pediatric Trials Network: Innovating to Make Drugs Safe and Effective for Children.” Join us! 🔗 duke.is/pctnews20260...

📣 In this week's PCT Grand Rounds, Ary Serpa Neto of @monashuniversity.bsky.social and Austin Health will present “Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit.” Join us! 🔗 duke.is/pctnews20260...

DCRI is proud to partner with the NIH Collaboratory to advance pragmatic clinical trials. In the latest #RethinkingClinicalTrials podcast, Duke's Brad Hammill, MS, and Keith Marsolo, PhD, discuss using death as an endpoint in pragmatic clinical trials.

📣 In this week's PCT Grand Rounds, Fran Balamuth of @upenn.edu and Scott Weiss of @jeffersonuniv.bsky.social will present “A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis.” Join us! 🔗 duke.is/pctnews20260...

The NIH Office of Disease Prevention will offer a webinar on treatment effect estimation in cluster randomized trials on July 29 as part of its Methods: Mind the Gap webinar series, featuring Bingkai Wang of the University of Michigan School of Public Health. duke.is/pctnews20260...

In the OPTIMUM trial, mindfulness-based group telehealth visits led to significant improvements in pain for patients with chronic low back pain. Learn more about the results of this innovative pragmatic clinical trial conducted in real-world primary care settings. duke.is/pctnews20260...

Congratulations to Fan Li, a longtime member of our Biostatistics and Study Design Core Working Group. Dr. Li received well-earned recognitions from ASPPH and COPSS for his foundational work in pragmatic trials research methods and his contributions to public health science. duke.is/pctnews20260...

🎙️ In a new episode of the NIH Collaboratory Podcast, Brad Hammill and Keith Marsolo of @dukemedschool.bsky.social discuss the challenges and methods associated with the use of death as an endpoint in pragmatic clinical trials. 🔗 Listen and subscribe: duke.is/pctpod

📣 In this week's PCT Grand Rounds, Phillip D. Levy of Wayne State University will present “Precision Engagement to Improve Population Health.” Join us! 🔗 duke.is/ptcnews20260...