Penninger Lab

Penninger Lab

@penningerlab.bsky.social

We take a holistic approach to understand health & disease and research cancer, immunity, nervous system, heart, blood vessels, bone and glycoproteomics. We are located in Vienna, Braunschweig and Vancouver.

514 followers340 following10 posts

Penninger Lab
@penningerlab.bsky.social

Thrilled to share that our UrineScore paper is published in @embomolmed.org 🎉 A protein-based urine test for non-invasive detection of clear cell renal cell carcinoma: no blood, no biopsy, just urine. 🧪 Thanks to the team! @meduniwien.ac.at @imbavienna.bsky.social link.springer.com/article/10.1...

link.springer.comUrinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma - EMBO Molecular MedicineClear cell renal cell carcinoma (ccRCC) is the most common kidney malignancy. Yet, no rapid, non-invasive biomarkers are available for diagnosis or screening. Urine represents an ideal analyte matrix ...
Penninger Lab
@penningerlab.bsky.social

Targeting glycosylation to sensitize breast cancer cells to immune therapy (make immunologically “cold tumors” into immunologically recognizable “hot tumors”). Thanks to @smereiter.bsky.social, the whole team and the T. Von Zastrow Foundation!

Stefan Mereiter@smereiter.bsky.social

🚨 Our newest manuscript is out in Nature Communications: Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential. +6 years in the making. Dive into: tinyurl.com/sialic @meduniwien.ac.at

tinyurl.comTumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer - Nature CommunicationsTumor sialylation has been associated with different mechanisms of immune evasion. Here the authors show that tumor sialylation regulates G-CSF stability to promote neutrophil-mediated immunosuppression as well dampens tumor cell immunogenicity by limiting MHC-I surface expression, limiting anti-tumor immunity in breast cancer.

Penninger Lab reposted

Helmholtz-Zentrum für Infektionsforschung (HZI)
@helmholtzhzi.bsky.social

Molekulare Diagnostik ist in vielen Ländern nicht gut verfügbar. Forscher:innen des @viennabiocenter.bsky.social & @imbavienna.bsky.social, darunter @mjkellner.bsky.social, mittlerweile Gruppenleiter am HZI, stellen @lsajournal.org einen neuen Test vor. www.life-science-alliance.org/content/8/10...

life-science-alliance.orgA lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settingsA critical bottleneck for equitable access to population-scale molecular diagnostics is the limited availability of rapid, inexpensive point-of-care tests, especially in low- and middle-income countri...
Penninger Lab
@penningerlab.bsky.social

An organoid platform to study bats' resilience to viral infections - spearheaded by Max and supported by a great team & collaborators: www.nature.com/articles/s41...

nature.comBat organoids reveal antiviral responses at epithelial surfaces - Nature ImmunologyKellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplif...
Max J. Kellner@mjkellner.bsky.social

Hi 🦋 I’m thrilled to share that our #bat #organoid work has found a publishing home in Nature Immunology! These models provided unprecedented insight into antiviral immunity at epithelial surfaces of the Egyptian fruit bat 🦇 — a natural reservoir of Marburg virus 🦠 www.nature.com/articles/s41...

nature.comBat organoids reveal antiviral responses at epithelial surfaces - Nature ImmunologyKellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplifying type III IFN responses that drive antiviral defense against zoonotic RNA viruses.
Penninger Lab
@penningerlab.bsky.social

🎓🧫🔬 Join our lab at Medical University of Vienna as a PhD student investigating glycobiology and cancer research! Details below 👇

Stefan Mereiter@smereiter.bsky.social

🚨 PhD position open! 🚨 Join our team at the Medical University of Vienna to study glycan regulation in mammary organoids, milk, and breast cancer. Details in the image – please share! 🧬✨

Penninger Lab
@penningerlab.bsky.social

Great collaboration on blood vessel organoids to model human vascular development and disease 🧫🔬

marinanikolova.bsky.social@marinanikolova.bsky.social

Happy to share our resource for blood vessel organoids! @zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social

Penninger Lab
@penningerlab.bsky.social

For research times have become more difficult in many places. We want to spread positivity and show appreciation for our city: We enjoy living and conducting research in Vienna – great science, hospitals, people & art! #IchForscheGernInWien #Wien

Penninger Lab reposted

Stefan Mereiter
@smereiter.bsky.social

1/ Hi 🦋! Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬 Curious about how they vary? Let’s dive in! #GlycoTime

Penninger Lab
@penningerlab.bsky.social

Perfect for our first post: big collaborate effort spearheaded by Masahiro Onji showing how sex hormones and RANK regulate gut expansion during reproduction 🤰🤱

Masahiro Onji@masaonj.bsky.social

Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators. The paper shows how RANK drives intestinal epithelial expansion during reproduction. #intestine #stemcells #pregnancy www.nature.com/articles/s41...

nature.comRANK drives structured intestinal epithelial expansion during pregnancy - NatureThe RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.

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