Periklis Paganos

Periklis Paganos

@perievodevo.bsky.social

I’m a Researcher @szndohrn.bsky.social and I use echinoderms as experimental systems to investigate the evolution of cell types and organs. 🌊⭐️🦔

165 followers183 following46 posts

Periklis Paganos reposted

Periklis Paganos reposted

Fantastic news!!! My project ECHINODEV has been awarded an ERC starting grant 🥳🥳⭐ We will use several echinoderm species to study animal body plan evolution! Reach out if you are interested, we will be looking for PhD students and postdocs 😀

📣 Good news! 📣 Results of the ERC 2026 Starting Grant call are out! Funding worth a total of €705 million will go to 421 early-career researchers across Europe. Discover who, what and where 👉 link.europa.eu/9M3MmN 🧪 #ERCStG #FrontierResearch #HorizonEurope 🇪🇺 @scienceinnovation.ec.europa.eu

Periklis Paganos reposted

Periklis Paganos reposted

Very excited to see our preprint on the monoaminergic signaling system in sponges (www.biorxiv.org/content/10.6...) featured by @qedscience.bsky.social. This highlights the importance of studying early-branching animals to piece together how the first animal cell types communicated with each other.

biorxiv.orgAn ancient monoaminergic signaling system coordinates contractility in a nerveless spongeChemical neurotransmission was a key animal innovation, enabling multicellular coordination of physiology and locomotion. Sponges are early-diverging animals that lack neurons and muscles, yet still c...
QED Science@qedscience.bsky.social

🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social

Together, our findings suggest that key ovarian cell types and components of reproductive neuroendocrine signaling have early deuterostome origins, some of which may predate the emergence of complex reproductive organs and neuroendocrine regulatory systems.

Periklis Paganos reposted

Periklis Paganos reposted

Periklis Paganos reposted

Periklis Paganos reposted

61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome. 🧬 Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology #preLight: prelights.biologists.com/highlights/e...

prelights.biologists.comEvolutionary landscapes of zygotic genome activation across animals - preLights61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome.

Periklis Paganos reposted

Issue 8 is now complete! On the cover: Embryos of diverse animals & choanoflagellates expressing different fluorescent reporters, from a project to identify membrane-localising tags across diverse organisms. See the Techniques and Resources Article by Karapidaki et al. doi.org/10.1242/dev....

Periklis Paganos reposted

Do you want to know when your favorite species activates its genome? Just input its genome size (🧬 in bp) and egg volumen (🥚 in um3) here! ZGA_onset = -2.37 * log10(gDNA/EggVol) + 11.74

Manuel Irimia@mirimiam.bsky.social

Then, what determines ZGA onset?? We correlated multiple genomic, developmental and ecological features with ZGA timing and, cutting to the chase, we found that the log ratio of genome size vs. egg volume very strongly scaled negatively with ZGA onset in cell cycles! 7/15

Periklis Paganos reposted

I am honored to have been involved in this super cool open-science project. Thanks, Michalis!

Michalis Averof@michalis-averof.bsky.social

Finding molecular tags that localise fluorescent proteins to the cell membrane was the goal of our latest paper, now published in Development @dev-journal.bsky.social. The tags act as address labels, sending proteins to the cell membrane, where they highlight the shape and arrangement of cells. 2/9

Thrilled to be part of this beautiful work! Stay tuned😉

Manuel Irimia@mirimiam.bsky.social

Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...

Periklis Paganos reposted

Thrilled to share that I’ve been awarded a FIS-3 Advanced Grant (ERC-inspired) to study the evolution of neurogenic GRNs. Recruiting soon: 4 postdocs + 3 PhDs Press release in Italian — to decolonise scientific language 😄 magazine.unibo.it/it/articoli/... Email me if interested in joining the lab

magazine.unibo.itUn viaggio all’origine dei sistemi nervosiIl nuovo progetto GRNevo, finanziato con un grant FIS-3 Advanced da 1,9 milioni di euro, studierà come si formano i neuroni durante lo sviluppo in specie animali molto distanti tra loro: dal moscerino...

Coolness alert!! If you didn’t attend this fantastic microscopy course last year, make sure you do so this coming April! Don’t miss the chance to learn from the best in the field. Plus, the course takes place at @szndohrn.bsky.social, one of the most iconic marine stations in the world!

Periklis Paganos reposted

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

bioRxivpreprint@biorxivpreprint.bsky.social

Evolutionary dynamics of temporal transcription factor series in the insect optic lobe https://www.biorxiv.org/content/10.64898/2026.01.08.698497v1

Periklis Paganos reposted

Periklis Paganos reposted

Congratulations to the all team for this amazing work understanding how the cis regulatory elements and chromatin organization are relevant in the ancestral regulatory features of animal genomes. This study started with a collaboration with José Luís Gómez Skarmeta from #CABD.

Arnone Lab@arnonelab.bsky.social

Exciting news to start the new year! We’re thrilled to see this work finally out in @natecoevo.nature.com, the result of a major collaboration between my lab and the labs of Veronica Hinman and Nacho Maeso, began many years ago with the dear José Luis Gómez-Skarmeta. www.nature.com/articles/s41...

Periklis Paganos reposted

Extremely happy to see this work out! I am deeply grateful to everyone who contributed, and especially to @danivoronov.bsky.social, who took the lead! @arnonelab.bsky.social sky is the limit! 🌊🔬🧬

Arnone Lab@arnonelab.bsky.social

Exciting news to start the new year! We’re thrilled to see this work finally out in @natecoevo.nature.com, the result of a major collaboration between my lab and the labs of Veronica Hinman and Nacho Maeso, began many years ago with the dear José Luis Gómez-Skarmeta. www.nature.com/articles/s41...

When you combine a brilliant scientist with strong grant support, the result is magic. This is exactly what the NEF project will deliver, nothing less!

Arnone Lab@arnonelab.bsky.social

I am deeply honored to share that my project NeurEvoFun has been awarded support from the Fondo Italiano per la Scienza (FIS), the Advanced Grant by the Italian Ministry of Education, Universities and Research, supporting fundamental research inspired by the ERC model. Excited for what’s ahead!

Periklis Paganos reposted

First #MicroscopeMonday contribution! Early auricularia larva of Holothuria tubulosa (4 days post-fertilisation, dpf) shown in brightfield (left) and with DAPI-stained nuclei (right, blue). Same larva. Same view. Bonus: this was also my first DAPI stain, imaged on an inverted microscope.

Periklis Paganos reposted

Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead! www.science.org/doi/10.1126/...

science.orgSingle-nucleus profiling highlights the all-brain echinoderm nervous systemA sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
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Adding to this complexity, we discovered a vast array of photoreceptor cells with a conserved retinal molecular fingerprint, as well as a population expressing a rare combination of opsins that we hypothesize is an ideal candidate for non-ocular sea urchin vision.

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Based on our findings, we report that the sea urchin juvenile body plan is head-like, similar to what has previously been demonstrated in sea stars and brittle stars, suggesting that echinoderms in general are predominantly head-like organisms.

Moreover, we found that the postmetamorphic nervous system, remarkable for its cell type diversity and complexity, also exhibits a head-like molecular signature and expresses vertebrate brain gene homologs.

Periklis Paganos reposted

Our lab studies how animals regenerate their body, e.g. how crustaceans regenerate broken legs. One of our aims is to understand if regeneration re-uses the gene networks that built the legs in the first place. Arthur Monternier, an artist in our team, captured the question in this cartoon.

Periklis Paganos reposted