Pfliegler Lab at University of Debrecen

academic.oup.com/gbe/advance-... Dissecting multiple hybridization events in a yeast lineage! "hybridization events in three phylogenetically related yeast genera - Torulaspora, Zygotorulaspora and Zygosaccharomyces - using a dataset of 172 genomes, 123 of which were newly sequenced" #yeastevolution

"measured the growth effects of 308,461 #yeast variants, identifying 18,009 with significant effects"

Not a bad place for some writing! Rimetea/Torockó, Romania

My paper on spice in farmhouse brewing is now *finally* published in Ethnobotany and Economic Botany.

I wrote a blog post about the new book, explaining why I wrote it, and what I'm trying to do with it www.garshol.priv.no/blog/445.html

Whole genomes of the Metschnikowia pulcherrima #yeast complex! #yeastevolution

I have finished reading the new book of @larsga.bsky.social about The Power of Beer! Absolutely stunning information overload, especially on historic trends, styles, and political economy, all from the perspectives of brewing. And of course, a lot about #yeast and how people domesticated it!

Population-specific transcriptomic shifts underlie secondary metabolic diversification in Aspergillus flavus Link and the domestication of Aspergillus oryzae (Ahlb.) #fungalevolution imafungus.pensoft.net/article/1952...

Time for some #Saccharomyces discussions and giving a talk at Wrocław Medical University!

While book chapters are frequently a bear to write, it’s always thrilling to get a physical object at the end. Thanks to my coauthors Chris and Barbara! We got the intro to yeast chapters for this nice volume from MBAA.

Right after the trip to Norway I came to beautiful Wrocław to meet collaborators from the Wrocław Medical University and to talk about clinical #Saccharomyces and genomes tomorrow:)

Keptinis making is truly spectacular at @kornolfest.bsky.social

Mika Laitinen presenting about historic daily cereal drinks of farmers

Keptinis brewing demonstration at the Norsk Kornølfestival!

I finally got the chance to taste the Norwegian Gamalost cheese, ripened with Mucor mold! Not your usual cheese :)

We are absolutely thrilled to be here in Grodås, Hornindal for the Norsk Kornølfestival to discuss #yeast , traditional fermentations and to taste an insane variety of local farmhouse ales w/ @balintnemeth.bsky.social @gergohorvath.bsky.social

The first non-chaotic(?) week of the semester is here when we can actually get work done! We welcome two new PhD students in the Lab, Soulafa from 🇸🇾 and Gergő from 🇭🇺 who will work with #yeast and other fungi! Good luck and welcome:)

Wow, Collaborative Yeast Cross clones, a library of 11,392 segregants! #yeast

I'm very proud of my students taking part at the Genetics Miniconference in Szeged today, showing their work for the first time! We divided the posters into 10 blocks, each for a student project:) Congratulations Team! #yeast #lablife

Very interesting story on #Aspergillus westerdijkiae in cheese caves! #fungalevolution

Visiting Riga and Latvia: what a nice sight, mobile kvass vendors! #yeast

"profiled fitness responses to over 600 bioactive and natural compounds, revealing broader and more polarized bioactivity than the standard #yeast gene-deletion collection" #Saccharomyces

"fungi are reliable biomarkers for gut maturation, with the notable emergence of #Saccharomyces and Malassezia as some of the strongest indicators. Fungal composition was strongly associated with infant age and with the later development of both atopic dermatitis and food allergy" #mycobiome

It is always a challenge but also fun to go back to partially completed projects: this manuscript supplementary file happens to be last modified in Nov 2020... Time to wrap things up! #Saccharomyces #lablife

www.sciencedirect.com/science/arti... Decoding alcoholic beverage and brewing practices of the Qin state during the Warring States period (475-221 BC) based on archaeological evidence. "Qin people mastered brewing and qu production during the Warring States period." #yeast

Prof. Csaba Szabó from University of Fribourg giving an invited talk at our University of Debrecen on the reproducibility crisis in #science!

Most of my at-home fermentation experiments are successful, this one is not :) It took me a looooot of time to get my hands on viable and pure Monascus from red yeast rice products. After inoculating to steamed rice, the Rhizopus-like and Aspergillus-like molds took over the slow-growing Monascus:

Low-level contamination confounds population genomic analysis and also phylogenomics in this example of #yeast #Saccharomyces. Very important: "Contamination rates differed however among sequencing centers: was high for 2 #Saccharomyces studies (2% or 15% of genomes)."

Exactly 10 yrs ago I had the incredible opportunity to observe horseshoe crabs in their natural habitat, a majestic species I first have seen in David Attenborough's Trials of Life series, back in the 90s, on VHS:) Happy 100th Birthday, Sir! naturephoto-walter.blogspot.com/2016/05/atla...

Real #cask ale or real ale from the UK is a wonderful beverage often described as a "live product", with live yeasts responsible from secondary fermentation and carbonation. I found only one scientific paper on cask ale pubmed.ncbi.nlm.nih.gov/36073539/ so I had to try isolating from it in London:)

Insights from sourdough redefine the domestication landscape of baker's #yeast. #yeastevolution Can't wait to read this @caitismuheil.bsky.social !

We are on a short trip in London, tasting some real #cask ale at The Lucas Arms :)

#Mycosphere This groundbreaking study reveals incredible hidden microbial diversity in tropical ecosystems and expands our understanding of fungal ecology. 🔬 Details: https://www.maxapress.com/article/doi/10.48130/mycosphere-0026-0002 #fungalecology #species #flowerstyle #ecosystems

In #yeast probiotic news: www.fzata.com/post/fzata-i... Fzata's new drug candidate, in fact a probiotic #Saccharomyces, FZ002, is designed to neutralize both of the main C. diff toxins (toxin A and toxin B). Clinical trials, sponsored by NIH, are planned to begin in summer of 2026 upon FDA clearance

Farmhouse #yeast show sexual competence, influencing their evolution trajectory #Farmhouse yeasts show phenotypic diversity but also common domestication traits #yeastevolution www.cell.com/current-biol...

Randy W. Scheckman presenting a special lecture at our University of Debrecen - he won the 2013 Nobel Prize in Physiology or Medicine for using baker’s #yeast to uncover the genetic machinery regulating vesicle transport!

Today we made great progress with a new multi-locus sequence typing approach under development for #Saccharomyces with two BSc students - this is all their work! Looking forward to analyze the sequences :)

Candida Genome Database’s new website is live! #yeast

With my recent trip to Rio de Janeiro, I managed to visit 26 Terrestiral Ecoregions of the 846 existing ones to do at least some nature photography and exploration. Still a lot to go! I also visited 9 Marine Ecoriegions (of 232) and 13 Freshwater Ecoregions (of 426).