Tigist Tamir

Tigist Tamir

@phosphotig.bsky.social

Out here wondering how cells cope with stress 🧐 tamirlab.org ● Metabolism, Cell signaling, Proteomics, Metabolomics, Systems bio, sci-comm ● Assistant Professor, Biochemistry & Biophysics ● 🤳🏾My opinions

1.9K followers1K following125 posts

We are hiring! Join our two awesome labs!

Chrystal Starbird@drstarbird.bsky.social

We are hiring! This is a joint Lab Assistant position with @phosphotig.bsky.social ‘s lab. If you are organized and creative, enjoy learning new things, and if working with two great teams of scientists sounds appealing, please apply! unc.peopleadmin.com/postings/319...

Tigist Tamir reposted

@hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits Stable, sustained support can transform your career: Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

bit.lyEarly Career Faculty Program | Freeman Hrabowski Scholars | HHMIThe Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

Tigist Tamir reposted

Really excited and proud to share this episode of “Standard Deviation”, part of the “Out of Patients” podcast where I talk about my work with LSEF and what motivated me to do advocacy work. It’s a packed 15-minute episode, so please listen when you have time! www.mzpod.com/standard-dev...

mzpod.comStandard Deviation S2 E2: The Advocacy TaxAt age 12, Dr. Chrystal Starbird stood by a pond after turning her mother in to the police. She watched tadpoles and fish move beneath the surface and found a stran…

Tigist Tamir reposted

Excited for the lab's first UNC Comp Med seminar. Yukun Niu will be presenting an exciting story that will be part of an upcoming preprint. Also, @phosphotig.bsky.social and SMS lab will be representing at ASBMB 2026 hope to see y'all there 😀 tamirlab.org/latest-news/yukun-at-unc-comp-med-seminar

tamirlab.orgWe are excited for Yukun to present her project at UNC Comp Med — Tigist TamirYukun will be presenting her project at UNC Comp Med Seminar this week!!

Fellow new PI success PSA! @krishnamudumbi.bsky.social et al have an awesome preprint out! Super psyched to connect with @jasonzxzhang.bsky.social as well, I see collaborations in our future 😀

Krishna Mudumbi@krishnamudumbi.bsky.social

Not new, but a new to us update: The first preprint out of my lab! We joined forces with @kinasekid.bsky.social @jasonzxzhang.bsky.social and David Baker to study protein phosphorylation! Congrats to Isabella from my lab on her first first author paper! tinyurl.com/43jwwfua

biorxiv.orgDe novo design of phosphotyrosine peptide bindersPhosphorylation on tyrosine is a key step in many signaling pathways. Despite recent progress in de novo design of protein binders, there are no current methods for designing binders that recognize phosphorylated proteins and peptides; this is a challenging problem as phosphate groups are highly charged, and phosphorylation often occurs within unstructured regions. Here we introduce RoseTTAFold Diffusion 2 for Molecular Interfaces (RFD2-MI), a deep generative framework for the design of binders for protein, ligand, and covalently modified protein targets. We demonstrate the power and versatility of this method by designing binders for four critical phosphotyrosine sites on three clinically relevant targets: Cluster of Differentiation 3 (CD3ε), Epidermal Growth Factor Receptor (EGFR), Insulin Receptor (INSR) and Signal Transducer and Activator of Transcription 5 (STAT5). Experimental characterization shows that the designs bind their phosphotyrosine containing targets with affinities comparable to native binding sites and have negligible binding to non-phosphorylated targets or phosphopeptides with different sequences. X-ray crystal structures of generated binders to CD3ε and EGFR are very close to the design models, demonstrating the accuracy of the design approach. A designed binder to an EGFR intracellular region phosphorylated upon EGF activation co-localizes with the receptor following EGF stimulation in single-particle tracking (SPT) experiments, demonstrating pY specific recognition in living cells. RFD2-MI provides a generalizable all-atom diffusion framework for probing and modulating phosphorylation-dependent signaling, and more generally, for developing research tools and targeted therapeutics against post-translationally modified proteins. ### Competing Interest Statement The authors have declared no competing interest. NIH NCI, 1K99CA293001

Tigist Tamir reposted

Are you an undergrad looking for a summer internship? Application season is underway! Check out these internship opportunities at Fred Hutch. Apply now: linktr.ee/fredhutch #datascience #statistics #labexperience

PSA! One of my favorite colleagues just put an awesome preprint out! check it out! #biochem @unc-bcbp.bsky.social

Rebecca Berlow@berlowlab.bsky.social

New preprint alert! We share some of our recent insights about sequence similarity in IDP protein families and find that conservative substitutions in well-conserved binding motifs of the CITED proteins have big impacts on their ensembles and functions. Take a look! www.biorxiv.org/content/10.6...

What an awesome initiative, check out @drstarbird.bsky.social et al raising everyone up 🥰

Chrystal Starbird@drstarbird.bsky.social

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond! www.wiley.com/en-us/resear...

Tigist Tamir reposted

$15k stipend to support 9 weeks of full time summer research! For rising juniors/seniors who are able to travel to and obtain housing at the location of the lab they are placed in! I did an HHMI summer experience in 2013 and it changed everything for me! Apply…or tell someone to apply! 🧪🧠

Leslie B Vosshall PhD@leslievosshall.bsky.social

@hhmi.org Summer Undergraduate Research Experience - #CechFellows named in honor of Prof Tom Cech Deadline to apply: 12/22/2025 Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!! www.hhmi.org/programs/cec...

Tigist Tamir reposted

🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗​​https://unc.peopleadmin.com/postings/308455 #Neuroscience #TeachingJobs #AcademicJobs #HigherEd

Tigist Tamir reposted

Attending #CellBio2025? Come join the Signaling Squad at our mini symposium on “Spatiotemporal Control of Cell Signaling Across Scales” in Room 120 from 9-11 am! I’m not saying we’re the best because there are so many great sessions, but it may be a save the best for last situation 😉

Tigist Tamir reposted

“The only reason I don’t have this funding is because my last name is Rodriguez.” MOSAIC checked many of the boxes of the administration — but that didn't matter. It was terminated, and left grantees scrambling Next installment of American Science, Shattered: www.statnews.com/2025/12/08/t...

statnews.comNIH shut out hundreds of young scientists from funding to start their own labsSpecial Report: The NIH has shut out hundreds of young scientists from funding to start their own labs.

Tigist Tamir reposted

Tigist Tamir reposted

Zara was an incredibly inspiring scientist, activist, and leader within our community of Leading Edge Fellows. She will be deeply missed by all those who had the pleasure of interacting with her.

Willow Coyote-Maestas@willowcoyote.bsky.social

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Tigist Tamir reposted

Zara was an inspiration. We never met in person but became friends through Leading Edge. She zealously advocated for her ideals, but was also passionate about helping others realize why they should too. Her loss is gutting & the world is the worse for it. RIP, I'll do my best to continue the fight.

Willow Coyote-Maestas@willowcoyote.bsky.social

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Tigist Tamir reposted

We are all better because of the energy, inspiration, brilliance, and tenacity that Zara was. A bright light, role model, advocate & snarky tweeter... everything I needed in a person when I was navigating dark times when we met in 2021. You will be missed deeply, Zara, but never forgotten ❤️

Willow Coyote-Maestas@willowcoyote.bsky.social

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Tigist Tamir reposted

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Tigist Tamir reposted

If you’re looking for some exciting reading to take into the weekend with you, please check out Haley’s first, 1st-author paper published in Science of the Total Environment this week! You won’t want to miss these wildfire smoke induced lipid changes!🔥💨 www.sciencedirect.com/science/arti...

sciencedirect.comWildfire smoke induces GM3 ganglioside lipid accumulation and transcriptomic shifts in mouse lung tissue: A smoke signal storyWildfire smoke is a growing concern due to continually rising exposures and links to numerous adverse health effects. Lipids are essential regulators …

Tigist Tamir reposted

Some awesome, fundamental work here: Lucy Shapiro, on bacterial cell differentiation, Dirk Görlich and Steve McKnight on IDRs & protein gels in nuclear pores and biomolecular condensates, & Michael Welsh, Jesús González & Paul Negulescu, (overdue) for bench to bedside work on cystic fibrosis 🧪 1/2

Carl Zimmer@carlzimmer.com

This year's Lasker Awards went to scientists who studied the wiring diagram of life, a new state of biological matter, and a potent treatment for cystic fibrosis. Here's my story with Gina Kolata. Gift link: nyti.ms/4mZlH1F

Tigist Tamir reposted

✨ #TuesdayInspiration We’re celebrating ASBMB members Luis Cedeño–Rosario & Elizabeth Kaweesa, recipients of the Dr. Eddie Méndez Scholar Award from @fredhutch.bsky.social. This award honors outstanding early-career scientists advancing research. Congratulations! #ASBMBmembernews ow.ly/qy1450WU9xk

ow.lyCedeño–Rosario and Kaweesa win research awardThe award honors outstanding early-career scientists studying cancer, infectious disease and basic science.

Tigist Tamir reposted

Congratulations to my great friend and colleague @bradylabupenn.bsky.social for this well deserved award! @pennmedcso.bsky.social @penncancer.bsky.social

Congratulations to the 2026 ASBMB Award Winners! Through their pioneering work, these scientists are advancing discovery, driving innovation, and shaping the future of molecular life sciences. Read more about their work: ow.ly/x05f50WSbax. #ASBMB26 #MakeItPossible

Tigist Tamir reposted

I am honored to be on the steering committee for this wonderful symposium that is highlighting scientists entering the job market. Tune in with us!

Tigist Tamir reposted

Hello world! Today’s officially the first day of the lab! It’s an empty space currently only filled with ideas (that I don’t have card access to yet 😂) but I’m excited for the science that will happen here! -JCG

Tigist Tamir reposted

In the past couple weeks, people have really stepped up to ensure all ABRCMS students have a great experience, so THANK YOU! There are still a few disciplines that could use some help: where are my Cell Bio, Cancer Bio, and Immunology folks at?!? abrcms.org/donate/stude...

abrcms.orgABRCMS Fundraising - Student Presentation Awards - ABRCMSJudges – Help Us Raise Funds for Student Presentation Awards Thank you for your service as a judge at ABRCMS. Your dedication has helped shape the future of countless student scientists, and we’re dee...
Chrystal Starbird@drstarbird.bsky.social

This makes me so happy! Let’s keep this momentum going and donate using the link below! CompBio is still rocking the lead! 🙌🏾 t.co/2pYnlaY7fz

Tigist Tamir reposted

History shows us the opposite: Undermining and censoring scientists and experts is a central feature of authoritarianism.

Republicans Against Trumpism@rpsagainsttrump.bsky.social

RFK Jr: We need to stop trusting the experts... Trusting the experts is not a feature of science or democracy, it's a feature of religion and totalitarianism.

Tigist Tamir reposted

Good 🧵on grant terminations

Scott Delaney@scott-delaney.bsky.social

NEW: Don't ask too many questions, but... NIH may not re-terminate the 900ish grants at issue in the main NIH lawsuits after all. To the PIs of reinstated grants, SPEND NOW! 🧵 Here's what NIH is probably thinking. Bear with me:

Tigist Tamir reposted

I'd love to spot "mitochondrial challenges" just by giving a look to people.

jen sometimes aph 🌻@bunnibytz.bsky.social

via @acyn.bsky.social RFK JR: I’m looking at kids as I walk through the airports today...and I see these kids that are just overburdened with mitochondrial challenges, inflammation—you can tell from their faces, movements, and lack of social connection

Tigist Tamir reposted

In case you were wondering how hiring a $10 million football coach when the Legislature is implementing $70 million in UNC-CH budget cuts starting in fiscal year 2025, with ~$29.5 million in cuts occurring this year, here the answer: for "safety" most of us are banned from much of campus Monday

Tigist Tamir reposted

If you are a researcher whose lab uses FlyBase, consider a tax-deductible personal contribution. A lot of $100 contributions would help bridge the gap until we can set up a user fee system, and even $10 donations send the folks there the message we're behind them. Please share

FlyBase@flybase.bsky.social

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

Tigist Tamir reposted

Guess what? We have an awesome seminar lined up for next week! Very excited to host Jess @unc-bcbp.bsky.social

Seminar Aug. 26 11 AM “Metabolic and physiological implications of flexibility in the electron transport chain” - Jessica Spinelli PhD, Asst. Professor, Program in Molecular Med., UMass Chan Medical School, Host: Dr. Tamir, Venue: 1131 Bioinf bldg. #MitochondrialFunction #ETC #MetabolicFlexibility

Tigist Tamir reposted

"This could be the difference whether your child gets cancer. Are you willing for them to die because the therapy for them is delayed?" Powerful video with voices from top US scientists on the very real and devastating impacts of the funding cuts.