pineurosci.bsky.social

pineurosci.bsky.social

@pineurosci.bsky.social

Neuropsych

463 followers89 following17 posts

pineurosci.bsky.social reposted

Desmond Oathes, PhD
@desmondoathes.bsky.social

Looking for a data analyst with good MRI skills and coding background ๐Ÿ’ป๐Ÿง ๐Ÿ‘ฉโ€๐Ÿ”ง. Sorry but visa sponsorship isn't an option. Kindly re-post! Apply here: wd1.myworkdaysite.com/recruiting/u...

wd1.myworkdaysite.comData TechnicianUniversity Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

pineurosci.bsky.social reposted

Sheila Shanmugan
@sheilashanmugan.bsky.social

We are currently recruiting a data analyst and a postdoctoral fellow to lead projects related to perinatal neuroimaging and reproductive psychiatry. Apply at the links below!

pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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pineurosci.bsky.social
@pineurosci.bsky.social

That psychedelics reduce bottom-up activity propagations into the DMN directly informs how we may think about their impact on brain function. These results support recent theories highlighting how psychedelics can attenuate bottom-up processing rather than strengthening it.

pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
View full thread
pineurosci.bsky.social
@pineurosci.bsky.social

2) These studies were nonclinical. Mental health associations can be opposite in healthy vs. clinical populations (x.com/pineurosci/s...). Xue Zhangโ€™s work, conducted in the sample from study 1, provides further insight into these directions (jamanetwork.com/journals/jam...).

x.compines (@pineurosci) on XQuick thread on our JAMA psych paper: multiple studies, often in large samples, report either positive or negative associations between cognition and mental health. What do you notice about the effect...
pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
View full thread
pineurosci.bsky.social
@pineurosci.bsky.social

To ensure that propagation results werenโ€™t reflecting previously-reported effects of psychedelics, we evaluated propagations alongside functional connectivity and activity autocorrelation. Brain and self-report associations with propagations were dissociable.

pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
View full thread
pineurosci.bsky.social
@pineurosci.bsky.social

To establish generalizability across a broad definition of psychedelics, we also evaluated psilocybin and LSD. To stress-test these findings, we evaluated 9 case-control comparisons across studies and imaging modalities. Effects were largely consistent.

pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
View full thread
pineurosci.bsky.social
@pineurosci.bsky.social

Specifically, we tested the idea that psychedelics increase bottom-up processing in the default mode network (DMN). In humans and mice, we used optical flow to describe the movement of cortical activity as vectors.

pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
View full thread
pineurosci.bsky.social
@pineurosci.bsky.social

Consequently, we sought to test a core tenet of existing theories on how psychedelics impact large-scale brain function: that psychedelics alter hierarchical processing in the brain. Some of these theories are nicely outlined here (pubmed.ncbi.nlm.nih.gov/36280799) although others have emerged since

pubmed.ncbi.nlm.nih.govThe neural basis of psychedelic action - PubMedPsychedelics are serotonin 2A receptor agonists that can lead to profound changes in perception, cognition and mood. In this review, we focus on the basic neurobiology underlying the action of psyched...
pineurosci.bsky.social
@pineurosci.bsky.social

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pineurosci.bsky.social reposted

Steven Meisler
@stevenmeisler.com

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development. ๐Ÿ”— www.biorxiv.org/content/10.6...

pineurosci.bsky.social reposted

Arielle Keller
@ariellekeller.bsky.social

Our paper on the โ˜€๏ธ "summer slide" ๐Ÿ› is out now @pnas.org! www.pnas.org/doi/10.1073/... Summer slide is a replicable phenomenon across diverse datasets that's more than "forgetting" school material in vacation months, but effects of socioeconomic inequality are โžก๏ธ 7x bigger! โฌ…๏ธ #PsychSciSky #DevPsy ๐Ÿงต๐Ÿ‘‡

pnas.orgCognition varies across the calendar year in multiple large-scale datasets | PNASChildren’s cognitive abilities vary across short and long timescales, from circadian fluctuations to year-by-year developmental changes. “Summer sl...
Arielle Keller@ariellekeller.bsky.social

โ˜€๏ธ New preprint! โ˜€๏ธ Cognitive tests from 23,000+ participants in 4 datasets show cyclical fluctuations across the calendar year, including a small but replicable โ€œsummer slideโ€ where youth show worst performance after school vacation. t.ly/OMzgl #PsychSciSky #CogPsyc #CogDev #devpsy #CogSci Thread /1

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PessoaBrain
@pessoabrain.bsky.social

๐—•๐—ฟ๐—ฎ๐—ถ๐—ป-๐˜„๐—ถ๐—ฑ๐—ฒ ๐—ฐ๐—ผ๐—บ๐—ฝ๐˜‚๐˜๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐˜€ Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice ๐—•๐—ฟ๐—ฎ๐—ถ๐—ป ๐—ฟ๐—ฒ๐—ด๐—ถ๐—ผ๐—ป๐˜€ ๐—ผ๐—ฟ ๐—ฑ๐˜†๐—ป๐—ฎ๐—บ๐—ถ๐—ฐ ๐˜๐—ต๐—ฟ๐—ฒ๐—ฎ๐—ฑ๐˜€? Dynamical processing winding through most brain regions. Looks like a must read. www.biorxiv.org/content/10.1... #neuroskyence

biorxiv.orgSpatially distributed and regionally unbound cellular resolution brain-wide processing loops in miceUntil recently, it has been possible to examine activity in the brain globally through regional averaging or locally at cellular resolution. These studies characterized regions as functionally homogen...

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Baller Lab
@ballerlab.bsky.social

The Baller Lab is thrilled to announce that @elenaccooper.bsky.social just had her first first-author publication! โ€œInvestigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocolโ€ is now published on BMJ Open: bmjopen.bmj.com/content/15/5/e094733! ๐Ÿง 

bmjopen.bmj.comInvestigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocolIntroduction Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects one million people in the USA. Up to 50% of patients with MS experience depression, yet the mechanisms of ...

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Sofie Valk
@sofievalk.bsky.social

We are seeking a scientific coordinator for my research group at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig ๐Ÿ˜Š๐Ÿง ๐ŸŒˆ Could be ideal for a gap year between MSc and PhD or PhD and postdoc! Please out more here: recruitingapp-5218.de.umantis.com/Vacancies/43...?

recruitingapp-5218.de.umantis.comScientific Coordinator (m/f/d) Part-time (50%) | Karriereportal Max-Planck-Institut fรผr Kognitions- und NeurowissenschaftenScientific Coordinator (m/f/d) Part-time (50%) | Karriereportal Max-Planck-Institut fรผr Kognitions- und Neurowissenschaften

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Zach Rosenthal
@zachrosenthal.bsky.social

Hot off the press! We found that electroconvulsive therapy (ECT) induces a previously undescribed, second brain event after seizure, called cortical spreading depolarization (CSD), using optical neuroimaging in both a mouse model to human patients. ๐Ÿงต below! doi.org/10.1038/s414...

doi.orgElectroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans - Nature CommunicationsThe underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a secon...

pineurosci.bsky.social reposted

Golia Shafiei
@goliashf.bsky.social

(1/18) Now out on BioRxivโ€ผ๏ธ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025... Funded by National Institute of Mental Health (NIMH)

doi.orgReproducible Brain Charts: An open data resource for mapping brain development and its associations with mental healthMajor mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...
pineurosci.bsky.social
@pineurosci.bsky.social

Super convincing results alongside treatment implications where options historically haven't been great. Thread below and in longer format on the other site x.com/PinesAndrew/...

x.comx.com
Andrew Pines@andrewpines.bsky.social

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n๐Ÿงต

pineurosci.bsky.social reposted

Boris Bernhardt
@borismontreal.bsky.social

Out in @natureneuro.bsky.social today ๐Ÿฅ‚ Cytoarchitecture, wiring and signal flow of the human default mode network Combining 3D histology, 7T MRI, and connectomics to explore DMN structure-function associations Led by Casey Paquola, @themindwanders.bsky.social & a terrific team of colleagues ๐Ÿ™

nature.comThe architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow - Nature NeuroscienceThe default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to input from the sensory cortex and a core relatively insulated from environmental input, and it uniquely balances its output across sensory hierarchies.

pineurosci.bsky.social reposted

Earl K. Miller
@earlkmiller.bsky.social

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy www.biorxiv.org/content/10.1... #neuiroscience

biorxiv.orgRarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchyThe brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations (categorical representations). Organization can also be found at the level of the representational geometry in the activity space, typically in the form of low-dimensional structures. It is still unclear how the geometry in the activity space and the structure of the response profiles of individual neurons are related. Here, we systematically analyzed the geometric and selectivity structure of the neural population from 40+ cortical regions in mice performing a decision-making task (IBL public Brainwide Map data set). We used a reduced-rank regression approach to quantify the selectivity profiles of single neurons and multiple measures of dimensionality to characterize the representational geometry of task variables. We then related these measures within single areas to the position of each area in the sensory-cognitive cortical hierarchy. Our findings reveal that only a few regions (in primary sensory areas) are categorical. When multiple brain areas are considered, we observe clustering that reflects the brainโ€™s large-scale organization. The representational geometry of task variables also changed along the cortical hierarchy, with higher dimensionality in cognitive regions. These trends were explained by analytical computations linking the maximum dimensionality of representational geometry to the clustering of selectivity at the single neuron level. Finally, we computed the shattering dimensionality (SD), a measure of the linear separability of neural activity vectors; remarkably, the SD remained near maximal across all regions, suggesting that the observed variability in the selectivity profiles allows neural populations to maintain high computational flexibility. These results provide a new mathematical and empirical perspective on selectivity and representation geometry in the cortical neural code. ### Competing Interest Statement The authors have declared no competing interest.

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PennLINC
@pennlinc.bsky.social

We're excited to release new versions of our BIDS-Apps for processing and analyzing #dmri data, QSIPrep and QSIRecon! Our team has been working hard to prepare these pipelines to process infant data and bring them in line with the @nipreps.bsky.social ecosystem. #neuroimaging #nipreps #bids 1/10

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Arielle Keller
@ariellekeller.bsky.social

Super excited to share our official ACORN Lab website!! ๐Ÿ๐Ÿง  appliedcognitionlab.psychology.uconn.edu We are recruiting new team members at the undergraduate, graduate, and postdoctoral levels - join us! #Neuroskyence #neuroimaging #PsychSciSky #CogPsyc #ClinPsych #CogDev #devpsy #CogSci

appliedcognitionlab.psychology.uconn.eduHome | Applied Cognition and Personalized Neuroscience LabWelcome to the Applied Cognition & Personalized Neuroscience Lab! ย  The Applied Cognition and peRsonalized Neuroscience (ACORN) lab is a collabora ...

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