A. Sánchez Alvarado

A. Sánchez Alvarado

@planaria1.bsky.social

An ongoing collection of places, ideas and people I run into during the practice of science

882 followers114 following81 posts

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Science is humanity’s grand endeavor to understand the universe & our place in it Every scientific breakthrough a testament to our curiosity & perseverance Science remains our compass, guiding us through the labyrinth of ideas, helping us distinguish truth from illusion, voices from echoes

A. Sánchez Alvarado reposted

🔬 NEW research from the Gibson Lab, published in Science Advances, reveals what sea anemones can teach us about human fertility! 🌊 The findings uncover surprising similarities in proteins essential for producing eggs and sperm. 🔗 bit.ly/4ieFxo6

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🔬 Happening this week at the Institute! We're welcoming scientists to #KansasCity for the #SRCKC26 on Ribosome Heterogeneity and Translational Control! Three days of scientific exchange, new ideas, and opportunities for collaboration. 🧬

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Taking big questions to new heights! 👀 Our new #WhatIf banners are officially up around the neighborhood! Go behind the scenes (and up in the air!) for a unique look at how they got there. Discover the questions driving our scientists: bit.ly/4yzLx1T

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Discover the newest tools transforming translational biology—from advanced ribosome profiling and proteomics to innovative imaging and functional genomics. 🧬 Join us at the 2026 Stowers Research Conference, #SRKC26. Register now: bit.ly/43Vb9so

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This #MicroscopyMonday shows the early formation of a small colony of corals from the Hawaiian Montipora capitata coral. Coral polyps have autofluorescence by the expression of the Green Fluorescent Protein. 🪸 (Gibson Lab)

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What if growing into an adult meant rewriting your cells? 🪱🔬 New #research from the Stowers Institute (@planaria1.bsky.social Lab) & @stanforduniversity.bsky.social reveals how the marine acorn worm transforms from larva to adult by reprogramming many of the cells it already has. 🔗 bit.ly/4hF99Mp

bit.lyStowers Institute and Stanford University study reveals a marine worm…New single-cell atlas of the acorn worm shows that most tissues undergo a genome-wide transcriptional overhaul as larva becomes adult, providing new…

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Replying to @hypothesisfund.bsky.social

2/ What if a new job changed your personality & extended your life? 🤯 Harpegnathos ants 🐜 do exactly that. Awardee Janko Gospocic is studying the epigenetics behind their caste-transitions, which could unlock new ways to reverse brain aging. 🎉 Congrats Dr. Gospocic! 🙏 #HFScout @planaria1.bsky.social

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Stowers Pres. & CSO @planaria1.bsky.social, welcomes our scientific community to #CRC26! From #research talks to poster presentations, this annual internal scientific meeting creates opportunities for scientists across career stages to share their work, learn from colleagues & make new connections.

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Stowers Graduate School alum Augusto Ortega Granillo, Ph.D., reflects on his time at the Institute and the experiences that helped shape where his scientific career has taken him today. Check it out ⬇️

Stowers Grad School@stowersgrad.bsky.social

From the Stowers Graduate School to @mpi-cbg.de 🧬 Alum Augusto Ortega Granillo, Ph.D., reflects on his journey at #StowersGrad and how pairing #biology with physics is shaping his #research today. 🔗Read more + applications are NOW OPEN: bit.ly/4xpAc2Y

A. Sánchez Alvarado reposted

From the Stowers Graduate School to @mpi-cbg.de 🧬 Alum Augusto Ortega Granillo, Ph.D., reflects on his journey at #StowersGrad and how pairing #biology with physics is shaping his #research today. 🔗Read more + applications are NOW OPEN: bit.ly/4xpAc2Y

bit.lyPairing biology with physics, from the Stowers Institute and beyondAugusto Ortega Granillo, Ph.D., reflects on his journey from the Stowers Graduate School to his postdoctoral research at the Max Planck Institute
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10/11 A word of caution: an atlas built from larvae may describe a different animal than one built from adults of the same species. Complex life cycles are not an oddity. Differences between two bodies may be written not in the roster of cells, but in the parts they're playing.

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8/11 One tissue refused to change costume. Mesoderm & muscle hold the same transcriptional profile on both sides of the metamorphic divide, even as their distribution in the body transforms completely. Whatever metamorphosis does to ectoderm & endoderm, it does not do to mesoderm

9/11 Nor is the divergence the work of a few stage-specific master genes. It is distributed broadly across regulatory, metabolic, and physiological programs, i.e., transcription factors and everything else alike, separating the two bodies.

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6/11 The naive reading that the larval cast is discarded, and an adult cast is conjured from set-aside cells (Peterson, et al, 1997) is not supported. Earlier work found no wave of larval death commensurate with replacement. So we labeled larval cells with EdU and waited.

7/11 43 days later, EdU+ cells born in the larva were still there in the juvenile proboscis, collar, and dorsal cord. They did not die. They stayed, and some of them are now expressing juvenile neural markers. The old cells are doing new jobs.

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4/11 Then we colored the same cells by life stage, and the result was arresting. Larval and juvenile cells occupy largely distinct transcriptional territories. Cells group by when they are, not by what they are...

5/11 This is not a UMAP artifact. In 55-dimensional PC space, larval gut clusters sit nearer to larval neurons than to any juvenile cluster, across germ layers. A larval neuron resembles a larval gut cell more closely than it resembles its own adult counterpart.

2/11 The enteropneust hemichordate Schizocardium californicum spends three months in the plankton as a transparent tornaria (a swimming head) before becoming a burrowing worm in the mud of Morro Bay. We charted five life-history stages by whole-body single-cell transcriptomics.

3/11 87,021 cells. 56 clusters. 12 cell classes: cartilage, ciliary band, endoderm, epidermis, immune, mesoderm, muscle, neural, pigment, proliferative, secretory, and one still unknown. Each validated in situ by HCR.

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Stowers scientists are featured in @fortune.com for their work with Google DeepMind on AlphaGenome Atlas—an AI-powered resource mapping predictions for 9 billion possible single-letter DNA changes across the human genome. 🧬 Read more about the collaboration: bit.ly/4x6NMYR

bit.lyGoogle DeepMind publishes AI-powered predictions for the effect of all 9 billion possible single-point mutations to human DNA | FortuneDeepMind's catalogue of predicted DNA mutation effects, could help scientists unlock the cause of rare genetic diseases and help them find cures.

A. Sánchez Alvarado reposted

Stowers scientists partnered with Google DeepMind to help advance AlphaGenome, an #AI model built to better understand how #DNA sequences regulate gene activity. 🔗 @statnews.com takes a closer look at the #technology and its potential for genomic #research, read the article here: bit.ly/4ikuUlF

bit.lyDeepMind launches AlphaGenome, aiming to predict gene regulation from DNA sequenceGoogle's DeepMind launches AlphaGenome, an artificial intelligence model that predicts gene expression from DNA sequence.

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(2/2) More on the @pnas.org study ⬇️ #neuroscience #scisky

Stowers Institute@stowersinstitute.bsky.social

(1/2) NEW #research from the Özel Lab 🧠 By mapping 232,251 cells in the developing fruit fly brain, Stowers scientists discovered that neurons actively build their identities during a critical window just after they are born. Read more about the @pnas.org study: bit.ly/3UATViG

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(1/2) 🎉 Congrats to Stowers Visual Storyteller and Multimedia Producer Jill Toyoshiba on her Mid-America Emmy nomination! Her nominated story dives into the fascinating coral #research happening right here at the Institute. 🪸 Watch the nominated video below and explore the story: bit.ly/4fAYkcb

A. Sánchez Alvarado reposted

(2/2) Watch part two below⬇️🪸

Stowers Institute@stowersinstitute.bsky.social

(1/2) 🎉 Congrats to Stowers Visual Storyteller and Multimedia Producer Jill Toyoshiba on her Mid-America Emmy nomination! Her nominated story dives into the fascinating coral #research happening right here at the Institute. 🪸 Watch the nominated video below and explore the story: bit.ly/4fAYkcb

A. Sánchez Alvarado reposted

A. Sánchez Alvarado reposted

How is translation regulated across different cell types, tissues, and organisms? Join us October 21–23 as experts explore ribosome heterogeneity, specialized ribosomes, translational control, and the technologies driving the next generation of discoveries. #SRCKC26 🔗 Register: bit.ly/43Vb9so

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This #MicroscopyMonday explores when nature plays with symmetry across species. A rare two-headed Killifish (left) and Zebrafish (right) conjoined larvae can occur, seen above with a fluorescent label marking the lateral line (a sensory system). 🔬(Piotrowski Lab)

On August 18 or 19 in 1936, the poet Federico Garcia Lorca was killed by a firing squad on the outskirts of Granada, Spain. He was 38. His body was never found Read him this month. The Romancero gitano, the New York poems, Bodas de sangre. Ninety Augusts later, the moon still comes into the forge

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#MicroscopyMonday | When the proliferation gene responsible for progenitor populations is disrupted (right), progenitors regenerate hair cells through direct differentiation in the absence of proliferation. Wild type neuromast (left). (Piotrowski Lab) #SciSky

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At this year's Faculty EDGE workshop, Stowers postdoctoral researchers refined their #research talks, practiced chalk talks, and received valuable feedback from visiting faculty at leading research institutions. 🔗Learn more: bit.ly/4wi0xzE

bit.lyFaculty EDGE: The conversations that shape careersThe Institute’s Faculty EDGE workshop, a key component of the Stowers Postdoctoral Training Program, prepares Stowers postdocs for what they will…

The Northern Harrier flies at the edge of falling. Its flight so slow that it is as if it was held aloft by desire alone. And when the flight ends and the Nothern Harrier lands in the tall grass and disappears from view, it is as if the entire field goes away with it.

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President and CSO @planaria1.bsky.social featured on Big Picture Science podcast⬇️

Big Picture Science@bipisci.bsky.social

Planarian flatworms have amazing regenerative abilities. After being sliced in half, wounds close within minutes, new eyes appear in days, and by day seven, the regenerated body is behaving like a functioning flatworm. @stowersinstitute.bsky.social bigpicturescience.org/episodes/wor...

Alexander Calder’s birth certificate says 22 July 1898. His mother insisted on August Fitting for a man whose life’s work was to show that balance is provisional, and that the finest structures are those still deciding where to rest

A. Sánchez Alvarado reposted

From specialized #ribosomes to translational control, the 2026 Stowers Research Conference will explore the latest discoveries shaping our understanding of protein synthesis across #biology. #SRCKC26 🗓 October 21–23, 2026 📍 Kansas City, Missouri Register now: bit.ly/43Vb9so

A. Sánchez Alvarado reposted

What if #AI could predict a cell's future? Researchers at the Institute and @helmholtzmunich.bsky.social are working toward that with RegVelo—an AI tool that helps reveal where cells are headed and what drives their fate. On #WorldAIDay, explore how AI is advancing #biology⬇️ bit.ly/4f7jlvZ

bit.lyNew AI Tool RegVelo Predicts Cell Fate & Gene Regulation | StowersStowers researchers unveil RegVelo, an AI tool predicting how cells change and identifying gene regulators to advance regenerative medicine.

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Evan Morrison, Ph.D., didn't always envision a career in #science. Today, he continues his @hhmi-science.bsky.social Gilliam Fellowship in the @kkostova.bsky.social Lab, where he's pursuing curiosity-driven #research to better understand how cells function. 🔗Read more: bit.ly/4wMAYqX

bit.lyFrom philosophy to proteins: Stowers postdoc continues his HHMI…Evan Morrison, Ph.D., a Stowers Institute postdoctoral researcher and a 2021 recipient of the Howard Hughes Medical Institute Gilliam Fellowship, followed…