Prof John Gordon

Prof John Gordon

@profcelentyx.bsky.social

B Cell Enthusiast; Immunology Prof (Emeritus, but Still Breathing); Big on Immunotherapy; Love Herefordshire; & Curries 😃 Any views and comments are strictly personal

191 followers105 following95 posts

Prof John Gordon
@profcelentyx.bsky.social

Incredible #infection #immunity #cancer #Bcells #Tcells Resource 👏 Top of the Human League 🙋‍♂️🙋‍♀️

bioRxiv Immunology@biorxiv-immuno.bsky.social

HuBIE: The Human Blood Immunome Encyclopedia Of TCRs and BCRs in Bloodstream Infections and Cancer https://www.biorxiv.org/content/10.1101/2025.10.22.678684v1

Prof John Gordon
@profcelentyx.bsky.social

#cancersky #immunosky #antibodysky Major #CD40 #TherapeuticAntibody Success now breaking @cp-cancercell.bsky.social First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer Fantastic work 👏

cell.comFc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancerOsorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...
Prof John Gordon
@profcelentyx.bsky.social

Major study, great work 👍

Chrystal Paulos@chrystalpaulos.bsky.social

🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back. 🔗 Read: www.cell.com/cancer-cell/... 🧬This unexpected immune duo sparks tumor immunity. 🖼️Image: See schematic Th17/B cell antitumor action!

cell.comAdoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunityCole et al. report that adoptively transferred, tumor-specific Th17 cells engage host B cells and drive B cell proliferation and differentiation. These Th17 cells require B cells for sustained immunit...
Prof John Gordon
@profcelentyx.bsky.social

#immunosky #cancersky #climatechangesky #PsychoNeuroImmunology #ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer? Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology

onlinelibrary.wiley.comInflammation Perfect Storm: Cancer, Climate and PolarisationInterplay between major global challenges and human health. Climate change and sociopolitical polarisation act as overarching amplifiers, driving specific environmental and psychosocial/policy-relate...
Prof John Gordon
@profcelentyx.bsky.social

A Perfect Selection 😉

Gabriel Victora@victora.bsky.social

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...

biorxiv.orgReplaying germinal center evolution on a quantified affinity landscapeDarwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
Prof John Gordon
@profcelentyx.bsky.social

Fantastic advance 👏

Thiago Carvalho@cyrilpedia.bsky.social

'Here, we report that Fc-optimized anti-CTLA-4 antibodies are potent remodelers of tumor vasculature that increase tumor-associated high endothelial venules (TA-HEVs), specialized blood vessels supporting lymphocyte entry into tumors' #Immunology #Immunotherapy www.cell.com/cell-reports...

cell.comFc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockadeBlanchard et al. reveal that Fc-optimized anti-CTLA-4 antibodies remodel tumor vasculature and increase tumor-associated high endothelial venules (TA-HEVs) that support T cell recruitment into tumors....
Prof John Gordon
@profcelentyx.bsky.social

Clucking Awesome 🐓

Discovery Immunology@discovimmunol.bsky.social

How do chickens generate antibody diversity? 🐔🔬 This study maps over 1 million gene conversion events in chicken antibodies, shedding light on how birds diversify their immune response. 🔗 https://bit.ly/45wSe95 #Immunology #VetImmunology #GeneConversion

Prof John Gordon
@profcelentyx.bsky.social

#Immunosky #Cancersky Antidepressants: A “Dead SERT” for #Immunotherapy! Open Access @cellpress.bsky.social @gilliangrafton.bsky.social 😎

cell.comSerotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axisSerotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...
Prof John Gordon
@profcelentyx.bsky.social

#ImmunoSky #InflammationSky #DietSky #ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22 "Trust Your #Gut" & Stay Off those Big Macs 🍔 @wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social

cell.comAcute exposure to high-fat diet impairs ILC3 functions and gut homeostasisXiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...
Prof John Gordon
@profcelentyx.bsky.social

#ImmunoSky #MedSky #drugrepurposing #Inflammation: "Time to halt the #Dopamine rush" An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis Now @science.org signaling

science.orgThe antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosisMacrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.
Prof John Gordon
@profcelentyx.bsky.social

#Bcells & #VaccinesSaveLives Towards a pan- #Flu #Vaccine Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody Breaking Open Access Study* @jem.org *https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine

linkedin.com#flu #vaccine #protective #antibody #jem #bcells #vaccinessavelives | John GordonTowards a pan-#Flu #Vaccine | Identification of a Seasonal Influenza Vaccine-induced Broadly #Protective Neuraminidase #Antibody | Breaking Open Access Study at Rockefeller University Press #JEM | #Bc...
Prof John Gordon
@profcelentyx.bsky.social

Targeting the #FcRn in #AutoimmuneDiseases: Pipeline & Progress Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review

link.springer.comTargeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress - BioDrugsAutoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-...
Prof John Gordon
@profcelentyx.bsky.social

👏 #Antibodies 👏 #Immunity 👏 #Influenza 👏 #Vaccines 👏 Thank Goodness for #Bcells 😊 On @britsocimm.bsky.social #Vaccine Engagment Day check out this exciting new study from @guthmillerjenna.bsky.social et al at @cp-immunity.bsky.social: www.cell.com/immunity/abs...

linkedin.com#bcells #immunity #vaccinedesign | John Gordon#Bcells | "STALK-ing 'Flu" at #Immunity Cell Press: "Playing the Long Game" | Major #VaccineDesign Study by Jenna Guthmiller et al Now Breaking Online | In…
Prof John Gordon
@profcelentyx.bsky.social

#Bcells #Antibodies #Vaccines #STALKing #Flu: "Playing the Long Game" Major #VaccineDesign Study by @guthmillerjenna.bsky.social & Friends now breaking at @cellpress.bsky.social #Immunity

cell.comLong-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutininsNext-generation influenza vaccines aim to overcome the limitations of current seasonal vaccines and generate durable and broadly protective immunity against influenza by targeting conserved epitopes. ...
Prof John Gordon
@profcelentyx.bsky.social

#Immunotherapy #Resistance #RAMP-ing up #Bcells makes #ICB therapy of #ESCC Nervous Open Access Study at @discovimmunol.bsky.social @britsocimm.bsky.social

academic.oup.comIntra-tumoural RAMP1+ B cells promote resistance to neoadjuvant anti-PD-1-based therapy in esophageal squamous cell carcinomaAbstractIntroduction. The application of neoadjuvant immunotherapy in esophageal squamous cell carcinoma (ESCC) reactivates anti-tumour immune responses an
Prof John Gordon
@profcelentyx.bsky.social

#Vaccines Novel strategy to boost immune responses in immunisation protocols @unisouthampton.bsky.social Immunologists / Cancer Biologists clearly on fire right now 🔥 Breaking publication at another @britsocimm.bsky.social journal @ceijournal.bsky.social this time 👏

academic.oup.comFcγRIIB (CD32B) antibodies enhance immune responses through activating FcγRsAbstract. Fc receptors (FcR) play a key role in coordinating responses from both the innate and adaptive immune system. The inhibitory Fc gamma receptor (F
Prof John Gordon
@profcelentyx.bsky.social

Terrific #ImmunoAgeing Review @jimmunol.bsky.social from @linterman.bsky.social & friends @babrahaminst.bsky.social "Thanks for the #Memory" #Bcells #GerminalCenter #Immunity #Infection #Vaccination #Antibodies

academic.oup.comThe cellular factors that impair the germinal center in advanced ageAbstract. Long-lasting immunological memory is a core feature of the adaptive immune system that allows an organism to have a potent recall response to for
Prof John Gordon
@profcelentyx.bsky.social

#Immunologists need to get out of the lab more 😉 #HygieneHypothesis #RunWild #RunFree #BGood

Gustavo Monasterio Ocares@gamonasterioo.bsky.social

Welcome to the jungle! 🌿🦠 Rewilded vs. lab mice: A better model for human mature immunity in B cell studies! ⬆️ Mature phenotype ⏫ Germinal centers 🔼 Gut B cells 🔼 Circulatory IgG & IgM—shaped by gut microbiota 🧪 www.science.org/doi/10.1126/...

science.orgRewilding catalyzes maturation of the humoral immune systemReleasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
Prof John Gordon
@profcelentyx.bsky.social

#Paediatrics | #Cancer | #ImmuneSystem | #Immunotherapy | Yet Another Phenomenal Resource from @petterbrodin.bsky.social & Friends | Breaking OPEN ACCESS Study Online at @cellpress.bsky.social | #immunogenicity | #Tcells | #inflammation |

cell.comSystems-level immunomonitoring in children with solid tumors to enable precision medicineIn a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunothera...
Prof John Gordon
@profcelentyx.bsky.social

Fantastic #Tregs work @jonasns.bsky.social et al 👏 Massive implications for #immunotherapy advances Finding @bsky.app really useful for picking up the occassional milestone study that may have otherwise slipped-the-net!

linkedin.comJohn Gordon on LinkedIn: #tregs #singlecell #suppression #regulatorytcells #immunotherapy#Tregs: Head-to-Head; One-by-One | #SingleCell #Suppression Profiling of Human #regulatoryTcells | Jonas N. Søndergaard et al drill down to individual Effector…
Jonas N. Søndergaard@jonasns.bsky.social

Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously. www.nature.com/articles/s41...

Prof John Gordon
@profcelentyx.bsky.social

#NKcells #Cancer #Immunotherapy Fingering the Mass Murderers & Serial Killers Fantastic work from @worboyslab.bsky.social @dandavis101.bsky.social & friends at @frontiersin.bsky.social #Immunology

linkedin.comJohn Gordon on LinkedIn: #cancer #immunotherapy #nkcells #cd8α #cd70 #human #cytotoxicity…#Cancer | #Immunotherapy | #NKcells | #CD8α and #CD70 mark #Human NK populations differing in #Cytotoxicity | Daniel Davis & Co.'s "I.D. Parade" finger Mass…
Worboys Lab@worboyslab.bsky.social

A recent study we were involved in is now online showing distinct populations of NK cells with different killing potential: www.frontiersin.org/journals/imm...

frontiersin.orgFrontiers | CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity
Prof John Gordon
@profcelentyx.bsky.social

#ImmuneCheckPointBlockade in #CRC: The More the Merrier 👍 New #Colorectal #Cancer #Immunotherapy #Resistance insights at @biorxiv-immuno.bsky.social online now From @icahn.bsky.social @mountsinainyc.bsky.social researchers 👏

linkedin.comJohn Gordon on LinkedIn: #immunotherapy #macrophage #tcells #immunecheckpointblockade #colorectal…#Immunotherapy | Coordinated #Macrophage ↔ #Tcells interactions mediate response to #ImmuneCheckpointBlockade in #Colorectal #Cancer | Multiple Immune…
Prof John Gordon
@profcelentyx.bsky.social

On International Day of Women and Girls in Science, remembering the late, great Eva Klein 1925 - 2025 Mother of #NKcells, #BurkittLymphoma lines, & much much more Honoured to have known and shared highly memorable times with Eva @ki.se 🇸🇪