Simon Waddington

Simon Waddington

@profsimonwad.bsky.social

๐˜—๐˜ณ๐˜ฐ๐˜ง๐˜ฆ๐˜ด๐˜ด๐˜ฐ๐˜ณ ๐˜ฐ๐˜ง ๐˜Ž๐˜ฆ๐˜ฏ๐˜ฆ ๐˜›๐˜ฉ๐˜ฆ๐˜ณ๐˜ข๐˜ฑ๐˜บ, ๐˜œ๐˜Š๐˜“ ๐˜Ž๐˜ฆ๐˜ฏ๐˜ฆ๐˜ต๐˜ช๐˜ค ๐˜ต๐˜ฉ๐˜ฆ๐˜ณ๐˜ข๐˜ฑ๐˜ช๐˜ฆ๐˜ด ๐˜ง๐˜ฐ๐˜ณ ๐˜ค๐˜ฉ๐˜ช๐˜ญ๐˜ฅ๐˜ฉ๐˜ฐ๐˜ฐ๐˜ฅ ๐˜จ๐˜ฆ๐˜ฏ๐˜ฆ๐˜ต๐˜ช๐˜ค ๐˜ฅ๐˜ช๐˜ด๐˜ฆ๐˜ข๐˜ด๐˜ฆ๐˜ด ๐˜ˆ๐˜ˆ๐˜, ๐˜ญ๐˜ฆ๐˜ฏ๐˜ต๐˜ช, ๐˜ข๐˜ฅ๐˜ฆ๐˜ฏ๐˜ฐ, ๐˜ฎ๐˜™๐˜•๐˜ˆ ๐Ÿงฌ๐Ÿšฒ

708 followers205 following170 posts

Simon Waddington
@profsimonwad.bsky.social

Sorry all, been a bit away from social media - but very happy to show our latest, slightly massive review on neuro gene therapy. Some quite amazing co-authors who dwarf me in their amazingness. Here, as a pre-proof. Still some (quite a bit) of finessing pharmrev.aspetjournals.org/article/S003... ๐Ÿงช

pharmrev.aspetjournals.orgGenetic therapies for neurological diseasesOften, gene therapy reviews concentrate upon specific therapeutic modalities โ€“ particularly either viral vector-mediated or a non-viral approach. Here, we draw together a comprehensive array of knowle...
Simon Waddington
@profsimonwad.bsky.social

I saw this about baby spiders eating their mother www.theguardian.com/tv-and-radio.... It validated something I saw as a child in the north of England. I was always poking arthropods; poked this spider and the body dissolved into fleeing tiny spiders. Mum never budged again. I thought I imagined it.

theguardian.comMother-eating spiders โ€˜will chill parents to the boneโ€™ in new David Attenborough seriesAfrican social spidersโ€™ sinister game of โ€˜grandmotherโ€™s footstepsโ€™ could be breakout moment in BBCโ€™s Parenthood
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Simon Waddington
@profsimonwad.bsky.social

A new paper hitting the press: Gene therapy for AIPL-1 retinal dystrophy. Almost all kids with this can only perceive light, at best. Getting early will help with vision also neurodevelopment and psychosocial aspects. ๐Ÿงฌ โญ ๐Ÿ‘ www.thelancet.com/journals/lan...

thelancet.comGene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional studyOur findings indicate that young children with AIPL1-related retinal dystrophy benefited substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual acuity and functional vi...
Simon Waddington
@profsimonwad.bsky.social

New paper out now - ascending infection during pregnancy results in neonatal morbidity - brain, lung, gut pathology - unique model of human newborn morbidity following infection-associated preterm birth @ucl-ifwh.bsky.social @dmacintyre.bsky.social ajp.amjpathol.org/article/S000...

ajp.amjpathol.orgAscending vaginal infection in mice induces preterm birth and neonatal morbidityPreterm birth (PTB; delivery <37 weeks), the main cause of neonatal death worldwide, can lead to adverse neurodevelopmental outcomes, as well as lung and gut pathology. PTB can be associated with asce...

Simon Waddington reposted

Dr Elodie Chabrol
@eloscicomm.bsky.social
Dr Elodie Chabrol@eloscicomm.bsky.social

โœจ๏ธPostdocs & PIsโœจ๏ธ I'm crafting an article with personal tips for PhD students on choosing and surviving postdocs. What advice do you wish you had or would give your younger self? What crucial insight do you wish you knew earlier? Share your wisdom! ๐Ÿ’ก @academic-chatter.bsky.social

Simon Waddington
@profsimonwad.bsky.social

Now live - our review of neurodegeneration in lysosomal storage disease - comparing and contrasting disease mechanisms; emerging evidence of unifying convergence @jimd-editors.bsky.social @ucl-ifwh.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.comUnifying biology of neurodegeneration in lysosomal storage diseasesThere are currently at least 70 characterised lysosomal storage diseases (LSD) resultant from inherited single-gene defects. Of these, at least 30 present with central nervous system (CNS) neurodegen...
Simon Waddington
@profsimonwad.bsky.social

1953 Rosalind Franklin ๐Ÿงช. She elucidated the structure of tobacco mosaic virus, showing that the RNA genome was embedded in the protein capsid, performed the foundation work to determine the structure of poliomyelitis virus, and provided the data to determine that DNA exists as a double-helix

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Simon Waddington
@profsimonwad.bsky.social

Finally, I learned that, on her gravestone, her contributions to virology were recognised. Buried in Willesden Jewish Cemetery, 3 miles from my house. So on a chilly morning today, 8th January I went there and took this picture. Each stone placed by someone showing her honour and respect.

Simon Waddington
@profsimonwad.bsky.social

1953 Rosalind Franklin ๐Ÿงช. She elucidated the structure of tobacco mosaic virus, showing that the RNA genome was embedded in the protein capsid, performed the foundation work to determine the structure of poliomyelitis virus, and provided the data to determine that DNA exists as a double-helix

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Simon Waddington
@profsimonwad.bsky.social

L to R: Anne Cullis, Francis Crick, Donald Caspar, Aaron Klug, Rosalind Franklin, Odile Crick, and John Kendrew April 1956, Madrid, International Union of Crystallography Creager ANH, Morgan GJ. After the Double Helix. Isis. 2008;99(2):239-72. (photo by Caspar)

Simon Waddington
@profsimonwad.bsky.social

So much more to learn about Rosalind Franklin than the oversimplification that Watson and Crick stole the Nobel Prize from her, doing her a disservice: that up to her death aged 37 she was a formidable force in genetics and structural biology and her work was fundamental to two Nobel prizes.

Simon Waddington
@profsimonwad.bsky.social

1953 Rosalind Franklin ๐Ÿงช. She elucidated the structure of tobacco mosaic virus, showing that the RNA genome was embedded in the protein capsid, performed the foundation work to determine the structure of poliomyelitis virus, and provided the data to determine that DNA exists as a double-helix

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Simon Waddington
@profsimonwad.bsky.social

I knew when I reached Franklin I had to do more than write about Photo 51 that led to the discovery of the DNA double helix. I disappeared into a cavern of her subsequent work on plant viruses genome packing, her work with Aaron Klug and Donald Caspar did a fellowship under her.

Simon Waddington
@profsimonwad.bsky.social

The more I dug, the more I realised how fundamental her work had been not only to the double helix Nobel prize, but also that of Klugโ€™s. And that she had a much better relationship with many researchers, including Watson, and particularly Odile and Francis Crick (Francis Crick was Odileโ€™s husband).

Simon Waddington
@profsimonwad.bsky.social

1953 Rosalind Franklin ๐Ÿงช. She elucidated the structure of tobacco mosaic virus, showing that the RNA genome was embedded in the protein capsid, performed the foundation work to determine the structure of poliomyelitis virus, and provided the data to determine that DNA exists as a double-helix

Simon Waddington
@profsimonwad.bsky.social

Thoroughly good account to follow ๐Ÿ‘‡๐Ÿป ๐Ÿ‘‡๐Ÿป ๐Ÿ‘‡๐Ÿป ๐Ÿ’Š๐Ÿ’‰๐Ÿฉธ๐Ÿงฌ๐Ÿฆ ๐Ÿงซ๐Ÿงช๐Ÿ”ฌโš—๏ธ๐Ÿฉป

1000WomeninSTEM@1000womeninstem.bsky.social

You'll have to wait a little longer, but her portrait is planned, it will be the 220th. #teaser