Replifate Consortium

The countdown to the RepliFate Final Conference is officially on, and the scientific programme is now live: replifate.eu/event/intern... #Munich2026 #MSCA #LifeScience #DNAReplication #GenomeStability #Chromatin

⏰ Missed the deadline? We've got you covered! Registration for the #RepliFate Final Conference has been extended until 15 June 2026. - 6 & 7 July | Helmholtz Munich - Outstanding speaker lineup & 12 MSCA fellows Register now: replifate.eu/event/meetin...

There's also a chance for YOU to share your science. 🔬 Registration closes 5 June 2026. 👉 Details + registration link: replifate.eu/event/meetin... #DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate

How do cells decide what they are? And how flexible that identity can be? A new study from María Gómez lab at @csic.es revealed that a subtle change in the speed of gene transcription can dramatically enhance a cell’s ability to revert to a stem-like state. Read more here: 10.1126/sciadv.adz6211

Highlights from the Egmond DNA Repair meeting: Julien shared our work, Sidak and Stella brought nice posters—and both got invited to give short talks. And the cherry on top? Stella won the Best Poster Prize, congrats! A pretty great week for the lab 🏆

Science meets art! Our first artistic experience as a lab working together with amazing artist Pei-Ying Lin. Very much looking forward to the final exhibition in Munich early July. @replifate.bsky.social

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social), revisits lesion bypass in light of recent advances DOI: 10.1016/j.tibs.2025.07.004

📌 La artista e investigadora Helen Pynor estuvo como Artist in Residence en el CBM con el proyecto europeo RepliFate. Su trabajo combina arte y biología molecular para plantear nuevas preguntas sobre la vida. 👉 Lee la entrevista completa: www.cbm.uam.es/index.php/20... @FateRepli

Our first bachelor student successfully defended her thesis! An impressive piece of lab work paired with a clear, engaging defence and discussion. Congrats! Many thanks to Panos Galanos (SDU) for serving as external examiner and for the thoughtful evaluation. Welcome to the academic club, Amélie!

This Tuesday, RepliFate Fellows traded pipettes for pitch decks in a full-day #entrepreneurship workshop hosted by Lead Discovery Center GmbH. 💡A great opportunity for our fellows to think differently about impact, #innovation, and #business development.

Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @cp-trendsbiochem.bsky.social: “Just bypass it: mechanisms of DNA damage tolerance” 🔗 doi.org/10.1016/j.ti...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

New cool research alert! Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA. Read the full study: doi.org/10.1038/s414...

Another exciting research article from a member of the #RepliFate network! The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis. Check out their findings here: doi.org/10.1016/j.ce...

Just published! Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication VCP/p97 = checkpoint gatekeeper! Read the full study: doi.org/10.1038/s414...

Frogs in the lab? Yep! 🐸 This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.

Our lab’s a little more crowded (and a lot more curious) this week! 🧠🐸 We’re thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts. They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.

#EuropeDay2025 On May 8, Emilio Lecona @emlecona.bsky.social and PhD students Ran Tong (@csic.es) & Scott Brian Churcher (@cbm-csic-uam.bsky.social) presented our network to students to show how we train researchers to study DNA replication in the fight against cancer 💡🧬

🔬 Science Through an Artistic Lens🎨 🧬Led by Prof. Maria-Elena Torres-Padilla, the #RepliFate Artist-in-Residence Program brings #artists and #scientists together. 👉 t1p.de/j5pi8 @epihmgu.bsky.social @metorrespadilla.bsky.social @ec.europa.eu @annadumitriu.bsky.social @replifate.bsky.social

Great initiative from the CSIC! We're proud to see RepliFate science shared with the public on #EuropeDay2025 — science belongs to everyone!

🌍 #ClimateActionDay is here! For the first time, the University of Copenhagen @ucph.bsky.social is joining forces to take real steps toward a greener future At BRIC @bric-ucph.bsky.social, we’re putting words into action! Small changes can make a big impact 🌱 #GreenLabs #SustainableScience

It’s time for new duo: Julius Thomas & his PI Lorenza Penengo from the University of Zurich. They study the ISG15 system in DNA replication—but there’s more! One could be found scaling alpine peaks, while the other might just trade the lab for the thrill of mushroom hunting. Curious to know more? 🍄

We’re kicking off our RepliFate introductions with @Phuc and her PI, @sylvie-noordermeer.bsky.social ! As part of the RepliFate network, they are contributing to exciting research in double-strand break (DSB) repair. Wanna know more about their work, hobbies, and fun facts? Check out their profiles!