Ronan Kapetanovic

Ronan Kapetanovic

@ronankp.bsky.social

Researcher in Immunology host-pathogen interaction, Macrophage vs Salmonella, 🔬🦠 (He/Him) | France, Tours, ISP, INRAE.fr | Former DECRA & MSCA.IF Fellow

2K followers1.5K following38 posts

Ronan Kapetanovic
@ronankp.bsky.social

Our work is finally out in Science Immunology ! This was an Amazing collaborative work from all co-authors, in particular the two co-first authors James Curson and Syeda Farhana Afroz . Never give up ! :) www.science.org/doi/10.1126/...

science.orgMitochondrial fission mediates an evolutionarily conserved antibacterial defense responseMitochondrial fission promotes antibacterial defense via the mitochondrial unfolded protein response and inducible lipid droplets.
Ronan Kapetanovic
@ronankp.bsky.social

A titanesque work that started 10 years ago in Matthew Sweet ‘s lab that show how mitochondria dynamics is controlling antimicrobial response via the mitochondrial unfolded protein response and an inducible lipid droplet production. We also highlight the key role of HDAC6 in this response.

Ronan Kapetanovic
@ronankp.bsky.social

Our scRNAseq data identify macrophages subpopulation that enable high zinc toxicity on E.coli. Our data suggest also a mechanism of starvation followed by toxicity that woiuld enhance the antimicrobial effect. As one anonymous reviewer nicely coined “the one-two punch”

Ronan Kapetanovic reposted

Isabelle Virlogeux-Payant
@ipayant.bsky.social

Happy to share our last paper. We show that the inoculation of 4 commensal bacteria to chicks has both short- and long-term effects on immune response and microbiota composition and promoted the low-shedder phenotype thanks to a more fermentative microbiota. www.tandfonline.com/doi/full/10....

tandfonline.comThe immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents Salmonella colonizationSuper- and low-shedding phenomena have been observed in genetically homogeneous hosts infected by a single bacterial strain. To decipher the mechanisms underlying these phenotypes, we conducted an ...
Ronan Kapetanovic
@ronankp.bsky.social

Nice work from @laurenpalmer.bsky.social ! Showing once more the important link between zinc, inflammation and antimicrobial response, Here, Acinetobacter baumannii.

Lauren Palmer@laurenpalmer.bsky.social

SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜

rdcu.beDietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in miceNature Microbiology - Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by...

Ronan Kapetanovic reposted

Isabelle Virlogeux-Payant
@ipayant.bsky.social

Perfect project for a post-doc! You will have access to a great set of data and we have already exciting hypotheses! Don’t hesitate to contact us.

Ronan Kapetanovic@ronankp.bsky.social

Looking for PostDoc - Metabolism/Salmonella. We are looking for candidates with excellent knowledge in bioinformatics and bacterial physiology / microbial ecology. We will help the candidate to build a successful application for European grants such as EMBO and Marie Skłodowska-Curie Actions.

Ronan Kapetanovic
@ronankp.bsky.social

Looking for PostDoc - Metabolism/Salmonella. We are looking for candidates with excellent knowledge in bioinformatics and bacterial physiology / microbial ecology. We will help the candidate to build a successful application for European grants such as EMBO and Marie Skłodowska-Curie Actions.

Ronan Kapetanovic
@ronankp.bsky.social

With all the new people, perhaps I should post an introduction. I am an immunologist identifying new antimicrobial responses in macrophages. My current research focuses on the use of metal ions (Zn & Cu) vs Salmonella infection. Always love to meet new faces and set up new collaborations. 🔬🦠

Ronan Kapetanovic
@ronankp.bsky.social

It’s out ! Our review on antibacterial responses in macrophages in @NatRevImmunol . We tried to cover as many pathways as we can, macrophages always astonish me by their immense arsenal. Very happy to have collaborated on that paper ! Version online FREE: rdcu.be/dUlUZ

rdcu.beInducible antibacterial responses in macrophagesNature Reviews Immunology - Macrophages are innate immune sentinels providing frontline defence against infection. This Review describes the inducible mechanisms used by macrophages to kill...
Ronan Kapetanovic
@ronankp.bsky.social

Last few days before deadline!

Ronan Kapetanovic@ronankp.bsky.social

Good news ! I’m looking for a post-doc (1 year ½ contract) to join our MiMoSa team at the @INRAE_VDL . Host-pathogen interaction project on understanding the dynamic of Zn and Cu during Salmonella infection. Deadline: Feb 11th, 2024. jobs.inrae.fr/en/ot-19561

Ronan Kapetanovic
@ronankp.bsky.social

Biology is never simple ! I’m happy to share our new publication on the role of HDAC6 on inflammasome. We used several methods (KO mouse, inhibitors, DARPIN…) to show that HDAC6 is NOT always driving the inflammasome and is context-dependent. DOI:https://doi.org/10.1016/j.jbc.2024.105638

Ronan Kapetanovic
@ronankp.bsky.social

I finally made it onto BlueSky ! I'm rebuilding my network slowly. I will try to update regularly my profile with (mostly) science while setting up my research at the INRAE ! Macrophages, Salmonella, metal ions (zinc) & mitochondria

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