Rosetta Commons

European RosettaCon 2026 is almost here! To join virtually, register at europeanrosettacon.org before registrations close on Monday, October 26 at 12:00am PT.

We are still exploring RFD4-Proteina, but, we also wanted to highlight the collaboration among the protein design community, including the Institute for Protein Design, NVIDIA, Rosetta Commons, and the OpenFold Consortium, that led to the open-source model’s development and release. zurl.co/4KSpO

Need some guidance on how to design antibodies with RFantibody? 🧬 Then, check out our latest tutorial. Learn from an expert the steps it takes to prepare an antigen, select a scaffold antibody, and use the Diffusion/MPNN/AF2 pipeline to produce novel CDR loops. zurl.co/7dHzx #TutorialTuesday

Meet Chaperone, a unified framework for making structural biology tools interoperable. Developed by the Institute for Protein Design, Chaperone makes it easier to build custom protein design pipelines. It is available now in the Rosetta Commons GitHub organization. Learn more: zurl.co/5URIT

Did you miss our Rosetta Commons Toolkit webinar last week on RFOptimization (RFO)? If so, the webinar is now available on YouTube! Tuscan R. Thompson from the IPD introduces RFO, a tool for improving existing protein designs through sequence optimization. rosettacommons.org/rctoolkit

Introducing makeshift, an open-source Python package that streamlines retrieving, curating, and analyzing biomolecular Nuclear Magnetic Resonance (NMR) data from the Biological Magnetic Resonance Data Bank (BMRB). Read more: zurl.co/7JRpC

For Day 3 of European RosettaCon 2026, here’s what’s on deck to wrap up the conference: Industry Applications Speaker Presentations Career Session Lisbon Guided Tours Not in Lisbon? You don't have to miss out on the talks—virtual registration is open! Sign up virtually: europeanrosettacon.org

Our new Enzyme Design with RFdiffusion3 Tutorial walks step-by-step through a basic enzyme design workflow—from cropping a metallohydrolase PDB active site into a theozyme to writing the JSON input file for RFD3 inference. Check it out here: youtu.be/htA3HSXCkro #TutorialTuesday

Did you miss our first Rosetta Commons Toolkit webinar? If so, not to fret, it is now available on the Rosetta Commons YouTube Channel. The webinar features Henry Dieckhaus from UNC Chapel Hill discussing ThermoMPNN. ⏯️Catch up now: rosettacommons.org/rctoolkit

Today is the last day of the 2nd Symposium on Protein Design and Engineering in Brazil, hosted by CNPEM! Events like this gathering are vital for driving computational protein design forward across South America, bridging local talent with the global scientific community. pages.cnpem.br/spde/

Join us tomorrow, Oct. 7 at 9 a.m. PT / 12 p.m. ET for our next Rosetta Commons Toolkit webinar, featuring Tuscan R. Thompson from the University of Washington, who will introduce RFOptimization, a newly released framework for all-atom biomolecular binder optimization. rosettacommons.org/rctoolkit

Researchers from @aiproteins.com introduce a streamlined workflow that could reshape how labs produce proteins at scale. The method tackles key bottlenecks across the entire protein production pipeline and is designed to be fully compatible with automation. Read more: zurl.co/kAHMW

Day 2 of European RosettaCon 2026, our invited speakers will dive into their research spanning: Microfluids, molecules & nanopores AI & language models for protein design Neurodegenerative disease biomarkers & vaccine antigen design Register today to attend virtually: europeanrosettacon.org

Looking to streamline your ML protein design workflows? 🧬✨ Rosetta Commons just dropped a new hands-on tutorial: "How to Build a Model with AtomWorks." You'll explore essential API functions, construct a custom dataset, and train a Graph Neural Network (GNN) model from scratch. zurl.co/znS8E

Meet Terra! Terra’s lab is interested in the physical principles underlying biological function. They integrate an interdisciplinary approach to design novel molecules that address environmental and medical challenges. Learn more about Terra in our September 2026 newsletter. zurl.co/w5cZk

Summer RosettaCon 2026 at the University of Washington was a week to remember. We spent August 3–7 jammed-packed with fascinating science, meaningful networking, and unforgettable memories— from trail hikes with friends to unwinding next to fossils after long days. Read the recap here: zurl.co/0UVrv

As part of the Tech Tea Time series, Ethan Holz, a software engineer for the Open Molecular Software Foundation (OMSF), led a discussion on the current state of building and using agents for computational workflows, covering tools like Claude Code, Pi, and Codex. 🎥 Watch here: zurl.co/PhLrM

Day 1 at European RosettaCon 2026, our invited speakers are taking the stage to share their research in: Computational & functional protein design Evolutionary design of ancient proteins Molecular dynamics & binder design Virtual registration is open! Register now: europeanrosettacon.org

Researchers developed a two-phase approach combining Rosetta-based motif grafting with deep-learning tools, including RFdiffusion, ProteinMPNN, and AlphaFold2 to generate high-affinity binders that successfully targeted bone regeneration. Read more: rosettacommons.org/2026/09/16/t...

Introducing the free monthly virtual series - Rosetta Commons Toolkit: A Practical Webinar Series for Biomolecular Modeling and Design! Our debut session features Henry Dieckhaus from UNC Chapel Hill taking a deep dive into ThermoMPNN. Every skill level welcome! rosettacommons.org/rctoolkit/

In the latest Protein Design Workflows Group presentation, Gianluca Quargnali (University of Zurich) introduces BioPipelines—an open-source Python framework that lets you define complex, multi-step protein and ligand design workflows in just a few lines of code. 🎥 Watch here: zurl.co/o5WWw

Researchers at Outpace Bio and the University of Washington present OUTLAST Regulators, de novo designed, compact protein modules that simultaneously modulate multiple target proteins to reprogram cellular pathways and sustain T cell functional persistence. Read more: zurl.co/Kkw2T

OpenBind announced the release of the OpenBind-0 model, a fully open-source co-folding model built on OpenFold3, trained on Protein Data Bank (PDB) data, and optimized for predicting protein–small-molecule complexes. Read more: zurl.co/W7FCy

Design2Data (D2D) is a nationally networked Course-based Undergraduate Research Experience (CURE) program. They are welcoming new members for the 2026–2027 academic year and invite you to consider joining them. Apply today: zurl.co/6Hqyw

The scientific program for European RosettaCon 2026 has officially arrived! 🧪 Explore the full line-up of speakers sharing their latest research across the three days, including 3 keynotes, 7 presentation sessions, and 3 poster sessions. Virtual registration is now open: europeanrosettacon.org

In a recent paper by Zach Drake and other members from the Lindert Lab, a new set of tutorials and updated PyRosetta implementations make using integrated structural mass spectrometry pipelines accessible to non-expert users. Read more: zurl.co/dKOro

Meet Kevin! Kevin’s lab is currently trying to uncover the identities of protein assembly components, determine their 3D structure, and modulate their activity. Learn more about Kevin in our August 2026 newsletter. rosettacommons.org/community/ne...

Prof. Tanja Kortemme is an innovator in computational protein design. Her research focuses on physical interactions at all scales, from atoms and molecules to complex biological systems. Hear her group's latest breakthroughs at European RosettaCon 2026! Virtual registration is open. zurl.co/h9iB1

Meet the 2026–2027 Rosetta Commons Postbac Trainees! 🧬 Adaym, Ainur, Cailyx, Daniel, and Linda started their journey at Johns Hopkins studying ML & protein design. Now, they’re diving into research across the King, Rocklin, Das, Khare, and Hosseinzadeh labs! rosettacommons.org/education/ra...

🧬 Want to stay updated on protein science? Check out the @bpdmc.org monthly presentation series! Recent topics: • Computational antibody design • Energy-based models & structure • De novo small-molecule induced changes Learn more, watch past presentations, and join the community at bpdmc.org.

Calling all job seekers! Following an engaging Summer #RosettaCon, our Jobs Board has been fully refreshed. We currently have 30+ open positions spanning both academia and industry, with opportunities available across career stages. Explore the open roles and apply today: rosettacommons.org/jobs/

Celebrating incredible service at Summer #RosettaCon! Congrats to this year’s Rosetta Commons Service Award winners: Jeffrey Gray — Over a decade of visionary leadership & founding our REU & postbac programs. Austin Seamann — Extraordinary dedication to education & producing Rosetta/ML tutorials.

Congratulations to our Summer #RosettaCon 2026 poster award winners: Hayden Stegall (Rice), Iris Zheng (JHU), Russell McLoughlin (UO), Gangeun Park (KAIST), Adrianne McCormick and Steven Engelbretson (UW). Thank you to everyone who shared their work, we learned so much from each of you!

Thank you to everyone who joined us at Summer #RosettaCon 2026—in-person and virtually! You make this community a place where groundbreaking science and celebrating each other go hand in hand. What was your favorite talk, poster, or experience from this year’s event? Share below!

At Summer #RosettaCon 2026, our invited speakers, Terra Sztain, Cameron Glasscock, Gyu Rie Lee, and Martin Pačesa, brought incredible research to the stage with fantastic presentations. Thank you to AstraZeneca for sponsoring the conference and helping us amplify scientific leaders.

Hands-on tutorials at Summer #RosettaCon 2026 gave attendees the chance to level up their skills—covering everything from AI agents and the Data Bazaar to essential documentation best practices. Thank you to Xaira Therapeutics for supporting the conference and these moments.

At Summer #RosettaCon 2026, meals gave trainees and established researchers a unique space to connect—sparking new collaborations, sharing career advice, and exchanging fresh ideas. Thank you to RA Capital for supporting the conference and helping fuel these meaningful connections for our community.