Science for ME (S4ME)

s4me.infoFact Sheet 4: Management of severe and very severe ME/CFSFact Sheet 4: Management of severe and very severe ME/CFS Published August 2026 Link to pdf: https://s4me.info/docs/Management of severe and very severe MECFS.pdf Discussion thread: Fact sheet #4 - M...

14 Aug

New Fact Sheet from the Science for ME (S4ME) Forum: "Management of severe and very severe ME/CFS" s4me.info/threads/fact... This is the fourth fact sheet published by the S4ME forum. I'll post links to the other three in the replies. 1/4 #MEcfs #SevereME #PwME #S4ME

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 19 - 25 Oct 2026

17h

Multi-omic analysis of post-acute sequelae of COVID-19 (PASC) — Beimers et al "Despite the diversity of complaints our cohort patients expressed, we found a consistent global multi-omic signature that was captured with bulk analyses." #MECFS

nature.comArticle Link

frontiersin.orgArticle Link

14h

Outcome measures in long COVID clinical trials: a review — Rhijn-Brouwer et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 19 - 25 Oct 2026

onlinelibrary.wiley.comArticle Link

23h

No evidence of hypercoagulability, altered fibrinolysis, or increased fibrin(ogen) microaggregates in never-hospitalized long COVID — Fraser et al #MECFS

ajp.amjpathol.orgArticle Link

20h

Effects of prolonged SARS-CoV2 spike protein exposure in long COVID and a mouse model of the disease — Nuovo et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 19 - 25 Oct 2026

hdl.handle.netArticle Link

Explaining Fatigue and Post-Exertional Malaise in Long COVID and ME/CFS: From Skeletal Muscle To Exercise Immunology — Charlton PhD thesis. #MECFS

The Glymphatic–Meningeal Lymphatic System and Autophagy in ME/CFS and Long COVID: A Mechanistic Perspective — Nemat-Gorgani et al "This perspective extends our earlier proposal that glymphatic dysfunction contributes to ME/CFS." #MECFS

mdpi.comArticle Link

s4me.infoNews in Brief - October 2026This thread has a Science for ME 'News in Brief' post for each week that begins in October 2026. The news team includes @Trish, @Kalliope, @ahimsa and @SNT Gatchaman. Scroll down to see this week's ne...

Our latest News in Brief weekly summary has headlines with links to further reading about ME/CFS, Long Covid, and related news for the week of Oct. 19 - 25: s4me.info/threads/news... #MEcfs #PwME #LongCovid #PwLC

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 12 - 18 Oct 2026

ijidonline.comArticle Link

Oral Fluid Inflammatory Biomarker Profile in Long COVID: Evaluation of Oral Active and Total MMP-8, MMP-9, and TIMP-1 in Relation to BMI and Disease Status — Aji et al #MECFS

publications.ersnet.orgArticle Link

Sputum and oral microbiota profiles are associated with long COVID severity and phenotype post-hospitalisation: a UK multicentre, prospective cohort study — Headley et al "the study recruited patients aged 18 years or older who were discharged from one of 83 NHS hospitals in the UK" #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 12 - 18 Oct 2026

Antiviral Antibody Fc Dysfunction Is Linked to Increased IgG1 Fucosylation in Long COVID — Ukey et al #MECFS

medrxiv.orgArticle Link

Long COVID is associated with lipoxygenase-catalyzed metabolism of essential polyunsaturated fatty acids — Moss et al #MECFS

cell.comArticle Link

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 12 - 18 Oct 2026

link.springer.comArticle Link

Measures of Overall Illness Severity and Burden for ME/CFS: A Scoping Review — Cripe et al "Our review indicates that studies vary widely in how illness severity and burden in ME/CFS are operationalized." #MECFS

Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVID — Painter et al #MECFS

biorxiv.orgArticle Link

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 12 - 18 Oct 2026

link.springer.comArticle Link

iPSC-derived myogenic progenitor cells from people with ME/CFS reveal altered genes and pathways with drug repurposing potential — Nguyen et al #MECFS

journals.plos.orgArticle Link

Identification of SGK1 as a candidate regulator associated with myeloid cell senescence in ME/CFS: An integrative transcriptomic and experimental study — Jin et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 5 - 11 Oct 2026

Choroid plexus enlargement in Post-COVID-19 syndrome is linked to Serum-Induced cytokine secretion in human hippocampal progenitors — Martins et al #MECFS

Handgrip strength parameters as predictors of post-COVID syndrome severity and muscle weakness in an observational study — Wallraven et al #MECFS

nature.comArticle Link

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 5 - 11 Oct 2026

Characterizing Pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Symptom Burden, Functional Impairment, and Comparison With Adults in the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study — Weaver et al #MECFS

jpeds.comArticle Link

Patient's knowledge, doctor's ignorance: The production of knowledge about myalgic encephalomyelitis — de Canson #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 5 - 11 Oct 2026

searchMECFS: An online, interactive platform to facilitate secondary use of biospecimens and associated research data from myalgic encephalomyelitis studies — Barnette et al #MECFS

rti.orgArticle Link

Exploratory clinical and immunological changes following Tixagevimab/Cilgavimab administration in immunodeficient patients with SARS-CoV-2-associated ME/CFS and persistent circulating spike protein — SEIDEL et al #MECFS

Our latest News in Brief weekly summary has headlines with links to further reading about ME/CFS, Long Covid, and related news for the week of Oct 5 - 11: s4me.info/threads/news... #MEcfs #PwME #LongCovid #PwLC

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 28 Sep - 4 Oct 2026

Hair cortisol concentration and basal heart rate variability differentiate long COVID from depressive disorders in youth — Oehlke et al #MECFS

Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome — O’Brien et al "Patients from this cohort with LCS, dysfunctional breathing and hypocapnia based on the lean test were referred for targeted pulmonary rehab." #MECFS

mdpi.comArticle Link

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 28 Sep - 4 Oct 2026

onlinelibrary.wiley.comArticle Link

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC) — Marmont et al #MECFS

portlandpress.comArticle Link

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans. — Gibler et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 28 Sep - 4 Oct 2026

Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection — Faraj et al #MECFS

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing — White et al #MECFS

mdpi.comArticle Link

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 28 Sep - 4 Oct 2026

scifiniti.comArticle Link

Pharmacological Treatment Approaches in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — Habermann-Horstmeier #MECFS

insight.jci.orgArticle Link

Autoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature — Chakravarty et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 28 Sep - 4 Oct 2026

The importance of work: A qualitative study of primary carers of severe ME patients’ experiences of balancing work with comprehensive caregiving responsibilities — Størdal and Iversen #MECFS

s4me.infoNews in Brief - September 2026This thread has a Science for ME 'News in Brief' post for each week in September 2026 by a team including @Trish, @Kalliope, @ahimsa and @SNT Gatchaman. Scroll down to see this week's news.

Our latest News in Brief summary has headlines and links to further reading about ME/CFS, Long Covid, and related news for the week of Sept. 28 - Oct 4: s4me.info/threads/news... #MEcfs #PwME #LongCovid #PwLC

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

The role of 6-minute walk test and pulmonary function testing in patients with post COVID-19 condition: a systematic review and meta-analysis — Khawandi et al "The overall certainty of the evidence was very low due to the high risk of bias, indirectness, and imprecision." #MECFS

dx.doi.orgArticle Link

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial — Faghy et al "The mean (SD) distance achieved in the 6MWT was 408 (113) metres at baseline compared to 468 (109) metres post-intervention" #MECFS

dx.doi.orgArticle Link

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

frontiersin.orgArticle Link

Serum NfL and GFAP in post-COVID syndrome: minimal evidence of CNS injury after adjusting for confounders — Wunderle et al "[ME/CFS] was present in 61.4% of PCS and absent in controls" #MECFS

thelancet.comArticle Link

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity: a sequential propensity score-matched cohort study — Morris et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence — Costa et al #MECFS

frontiersin.orgArticle Link

A systems microbiology framework for reproducible multi-dataset omics integration with application to long COVID — Varga et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

DNA methylation: unifying framework for complex chronic conditions — Sharma et al Review. #MECFS

cell.comArticle Link

onlinelibrary.wiley.comArticle Link

Clinical Symptomatology, Cognition and Psychosocial Wellbeing in Adolescents With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Cross-Sectional Observational Study — Chau et al #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

Evaluation of an Integrated Multidisciplinary Care Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Open-label, Non-randomized Controlled Intervention Study — Peters et al #MECFS

amjmed.comArticle Link

umontreal.scholaris.caArticle Link

Role of haptoglobin and its phenotypic variations in the pathophysiology of myalgic encephalomyelitis and long COVID — Moezzi PhD thesis. #MECFS

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

journals.physiology.orgArticle Link

Hemodynamic Phenotyping in ME/CFS and ANOCA: Complementary Insights from Coronary Function Testing and Invasive Cardiopulmonary Exercise Testing — Mackay et al #MECFS