sambooker.bsky.social

frontiersin.orgFrontiers | Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X SyndromeIntroductionFragile X Syndrome is a common, inherited single gene cause of intellectual disability, associated with autism, epilepsy, anxiety, and sensory di...

We just published a thing! www.frontiersin.org/journals/pha... Here we show that somatostatin interneurons display exaggerated LTP in a mouse model of Fragile X Syndrome, and which is sensitive to GABAB receptor activation; but which are not manifested at the circuit level - more work to do!

15 Jan

This raises the interesting question of how many single-cell phenotypes in this model are effectively compensated for to maintain network fidelity....

@edinunineuro.bsky.social

15 Jan

Amazing work by Max Wilson, Ania Sumera, and Emre Berk - with exceptional support from UK MRC @ukri.org, @sidb-edinburgh.bsky.social, and @edinunineuro.bsky.social

sambooker.bsky.social reposted

Edinburgh Neuroscience

24 Oct 2025

New @who.int Global Status Report on Neurology calls for urgent action to address the growing burden of neurological disorders & to promote brain health for ALL. @arinatam.bsky.social co-authored Ch4: Effective, timely & responsive diagnosis, treatment & care. Full report: edin.ac/43r3P7U

who.intwho.int

WHO@who.int

1 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism. Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH

biorxiv.orgFMRP regulates adult human cortical excitability via cyclic-AMP signallingFragile X Syndrome (FXS) is a common inherited neurodevelopmental condition, resulting from loss of Fragile X Messenger Ribonuclear Protein (FMRP). Rodent models of FXS display cellular hyperexcitabil...

www.biorxiv.org/content/10.1... super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.

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With insane support from @sidb-edinburgh.bsky.social @edinunineuro.bsky.social @ukri.org @patrickwildcentre.bsky.social and help from @vectorbuilder.bsky.social

This work hopefully identifies new models of neurodevelopmental conditions which can revolutionise future research.

This work has been championed by Max Knops and @sorayam.bsky.social, and many other colleagues, not limited to: Max Wilson, @bonthronphd.bsky.social @l-w-taylor.bsky.social Alsadeg Bilal, Imran Liaquat, Paul Brennan, @clairedurrant1.bsky.social

3 Sept 2025

Hello world! We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits https://www.biorxiv.org/content/10.1101/2025.09.01.672986v1

3 Sept 2025

Despite an absence of AIS shortening in response to sustained activity modulation, we do see other functional changes associated with homeostatic plasticity - including changes in membrane excitability and NMDA receptor function

annualreports.simonsfoundation.orgScottish Neuroscience Initiative Takes Basic Science From Lab to ClinicThe Simons Initiative for the Developing Brain aims to discover biological mechanisms underlying autism and related neurodevelopmental disorders and to use that information to deliver therapeutic…

3 Sept 2025

This work was led by Ania Sumera and Laura Oliveira, but with help from immensely talented students and collaborators, and @edinunineuro.bsky.social @sidb-edinburgh.bsky.social

sambooker.bsky.social reposted

Simons Foundation

@simonsfoundation.org

13 Aug 2025

Meet the Simons Initiative for the Developing Brain: a center devoted to deconstructing the secrets of neurodevelopmental disorders and the developing brain. Read more: annualreports.simonsfoundation.org/2024/scottis... #science #neuroscience

nature.comPhylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature CommunicationsGABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...

What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...

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This work would not be possible without the patients, our funders @sidb-edinburgh.bsky.social, UK MRC, @edinunineuro.bsky.social

And amazing collaborators @clairedurrant1.bsky.social @sorayam.bsky.social @l-w-taylor.bsky.social among many others not on here :)

What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...

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Further, we show that presynaptic GABAB receptors signalling is stronger in human cortical inputs than rodents. This leads to differential control of cortical oscillations.

Finally, we show show that GABAB receptor currents are elevated in patients who receive the anti-seizure medication Levetiracetam - regardless of seizure history.

What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...

rdcu.beDivergent actions of physiological and pathological amyloid-β on synapses in live human brain slice culturesNature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

In this we find that postsynaptoc GABAB receptors signalling undergoes developmental maturation in cortical columns, but is largely stable over adult human life.

sambooker.bsky.social reposted

Dr Soraya M

@sorayam.bsky.social

30 Apr 2025

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

8 Mar 2025

Friday saw two momentous occasions. The first major study accepted from our lab 🥳 and my 5 year old reciting to me the principles of synaptic strengthening in learning and memory. Immensely proud of both...