Susan Gregurick

Solid-state laser refrigeration of nanoscale quantum sensors | PNAS www.pnas.org/doi/10.1073/.... Cool.

Bridge2AI recommendations for AI-ready genomic data academic.oup.com/bioinformati... 🧪 AI-ready datasets must preserve sufficient structured metadata to enable automated and reproducible interpretation. recommendations and standards for metadata given here are quite detailed.

Elucidating and exploring specialised plant metabolism through a pangenomic and pantranscriptomic lens - Choudhary - 2026 - The Plant Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/.... 🧪 great review with lots of open questions worth exploring

Designing Pilot Studies for Embedded Pragmatic Clinical Trials | NEJM Evidence evidence.nejm.org/doi/full/10..... review summarizes ideas for designing pilot ePCTs, drawing from prior work, and outlining specific features with experience from the NIA IMPACT Collaboratory’s Pilot Grant Program.

Modeling Reactions on the Solid–Liquid Interface with Next Generation Extended Lagrangian Quantum-Based Molecular Dynamics pubs.acs.org/jpccck/artic.... 🧪. first demonstration of XL-BOMD applied to heterogeneous electrocatalysis, simulating electrode & electrolyte together in a unified framework

link.springer.com/article/10.1.... 🧪. Interesting study. I would love to see a broader study beyond those of European ancestry.

Experiences developing structural biology tools with AI coding assistance doi.org/10.1107/S205... 🧪. Agents increased speed, reduced memory use and direct integration with native data structures to assist in determining structures from X-ray Crystallography.

www.sciencedirect.com/science/arti.... 🧪 Nice study algorithm provide insight on the potential of metabolomics-informed precision medicine strategies for inflammatory diseases.

www.nature.com/articles/s41... 🧪 nice work finding G protein conformation can be dynamically tuned by the GPCR, sampling a continuum of states rather than a simple on and off state.

How did Rosalind Franklin miss the helix in her iconic DNA image? She didn’t | Science | AAAS www.science.org/content/arti.... 🧪

www.nature.com/articles/s43.... 🧪 very cool. No more finite differ- ences, coupled-perturbed equation solvers. Looks promising.

When the Chatbot Leaks: Securing Patient-Facing Medical AI in the Age of Dual-Use Large Language Models | NEJM AI ai.nejm.org/doi/full/10..... Article makes the case for prototyped frameworks need security and data governance practices expected of other clinical digital tools. 🧪

PWAS Atlas: a comprehensive knowledgebase of proteome-wide association studies academic.oup.com/nar/article/.... 🧪 this resource manually curates protein-trait associations from published studies with harmonized PWAS results.

Real-space chemistry on quantum computers: a fault-tolerant algorithm with adaptive grids and a transcorrelated extension pubs.rsc.org/dd/article/d.... 🧪. Theoretical work employs multicenter grids, rooted in DFT which rarely exceed 105 points per atom. Researchers illustrate point on H2 simulation

Peer Bork (1963–2026): pioneer of computational biology, architect of bioinformatics resources, and visionary microbiome researcher academic.oup.com/bioinformati... a really great article on the impact of Peer and how he approached life.

journals.plos.org/plosone/arti.... Cool. Researchers demonstrate that FANS-isolated nuclei are compatible with a wide range of genomic assays, including profiling of DNA modifications, histone modifications, chromatin accessibility, and gene expression.

The unfolded protein response in precision oncology: from mechanisms to therapeutic opportunities: Trends in Molecular Medicine www.cell.com/trends/molec.... 🧪 interesting article on Single-cell and spatial transcriptomics to provide dynamic, multigenic unfolded protein response signatures.

User Beware: Inaccuracy and Inconsistency of Large Language Models in Providing Precision Dosing Recommendations for Patients With Kidney Impairment—A Case Series - Hambrick - 2026 - Pharmacotherapy accpjournals.onlinelibrary.wiley.com/doi/10.1002/... 🧪

www.nature.com/articles/s41... 🧪. Interesting conceptual design for a fault-tolerant photonic quantum computer.

www.nature.com/articles/s41... 🧪

link.springer.com/article/10.1.... 🧪

Short‐Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing - Andrews - 2026 - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/... 🧪 study finds balanced diet rich in complex carbohydrates, derived minimally processed sources yield positive results

www.nature.com/articles/s41... 🧪 just out. Includes a AD-phenotypic single-cell atlas and a framework with open-source tools and pre-trained models

Convex approaches to isolate the shared and distinct genetic components of complex traits academic.oup.com/bioinformati.... Nice work breaking the Z score matrix as a sum of 2 components: a low-rank matrix of shared genetic signal across traits & a sparse matrix representing trait-specific effects🧪

link.springer.com/article/10.1.... Improved methods provides lower false positives and negative rates. 🧪

Artificial intelligence for Amazonian health: validation is the price of entry - The Lancet Regional Health – Americas www.thelancet.com/journals/lan... 🧪 great read. Makes the point health “innovations deliver optimal results when governance and execution are rooted locally”

Next‐Generation Manufacturing: The Evolving Role of Biocatalysis in AstraZeneca chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... neat article that explains how biocatalysis went from niche to a core capability through high-throughput screening, directed evolution, and process development.

mentalhealth.bmj.com/content/29/1... highest risk occurred during the unexposed period immediately before starting treatment. The findings across various health systems do not support ADHD medications as the main driver of self-harm.

How Repeal of the NTAP Alternative Pathway will Impact U.S. Clinical AI Innovation | NEJM AI ai.nejm.org/doi/full/10.... The elimination of the NTAP alternative pathway will disadvantage independent developers and researchers.

link.springer.com/article/10.1.... 🧪 nice work

link.springer.com/article/10.1... 🧪. Interesting work examining dynamic and common regulatory pathways across different disease states.

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort | Science www.science.org/doi/10.1126/... study illustrating which genes & metabolites change over time; how much individuals diverge from populations and how trajectories are shaped by intrinsic factors

arxiv.org/html/2503.19... 🧪 interesting

HPV Vaccination and Risk of Head and Neck Cancers: A Large Real-World Cohort Study - International Journal of Infectious Diseases www.ijidonline.com/article/S120... 🧪 Study found HPV vaccination is associated with a substantially lower risk of head &neck cancer

Conformational ensembles of flexible multidomain proteins: How close are we to accurate and reliable predictions?: Biophysical Journal www.cell.com/biophysj/ful... work

Hybrid artificial intelligence and quantum annealing as an optimization layer in drug discovery www.cell.com/patterns/ful... great review of quantum computing, annealing and multi-objective optimization in drug discovery includes potency, selectivity, pharmacokinetics, toxicity, & manufacturability

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/.... 🧪 Highlights of the workshop included significant advancements in biophysical/molecular modeling for vaccines and multi-scale applications, and mechanistic models for filtration.

Moderna cancer vaccine stops melanoma returning: what’s next for personalized treatments? www.nature.com/articles/d41... exciting development for a cancer vaccine according to each person’s cancer gene mutations, and once injected, it instructs the body to recognize the threat.

Rashba Engineering at van der Waals Interfaces pubs.acs.org/ancac3/artic...

journals.plos.org/ploscompbiol.... Work illustrated MCCP identifies prediction sets with prespecified control of the error rate, maintained valid calibration, and identified individuals for whom no reliable prediction could be made, and information on the confidence associated with each prediction

New research reveals a 3D morphogenetic process in breast cancer where macrometastases activate a metastatic trabecular morphogenesis (MTM) program, repurposing developmental pathways for expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #RNA 🧪

Navigating fairness in artificial intelligence-based prediction models: theoretical constructs and practical applications www.thelancet.com/journals/lan... 🧪 nice work that introduces a framework based on the model’s intended use, decision type, and ethical principles of distributive justice

Replacing Quantum Chemistry With Machine-Learned Interatomic Potentials: Revolution or Evolution? pubs.acs.org/acscii/artic.... 🧪 nice prospective on MLIPs.

Generative design of bacteriophages with genome language models | Science www.science.org/doi/10.1126/... 🧪 authors found generated phages different from known natural phages and exhibited de novo mutations and divergent genes. Cool.

💊 Fainting is common, and often ignored A new NEJM review says syncope stems from reflex, orthostatic, or cardiac causes. In older adults it can look like an unexplained fall, so spotting the risky kind early matters. 🔗 doi.org/10.1056/nejmcp2517255 #Health #Medicine #Cardiology 🧪

www.nature.com/articles/s41... 🧪 I get excited when T2T sequences come out.

www.nature.com/articles/s41... molecular dynamics simulation enables design of synthetic peptides that self-assemble into transmembrane barrel-stave pores (TBPs) that can modulate membrane permeability with high precision

journals.plos.org/ploscompbiol... 🧪 twelve tips for AI coding tools with rigor and code quality information and a nice implementation strategy. Also a good reference resource.

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders | Science www.science.org/doi/10.1126/... 🧪. Nice study of metabolomic profiling of lysosomal aging across tissues and species

www.nature.com/articles/s41.... 🧪 really nice review