SheinerLab

SheinerLab

@sheinerlab.bsky.social

Research lab interested in #parasites #apicomplexa #toxoplasma #toxoplasmosis #plasmodium #malaria #mitochondria #cell-biology https://lilachsheiner.wixsite.com/sheinerlab-wtcmp

289 followers81 following58 posts

Calling all parasite enthusiasts in and around Scotland 👇

SPPIRIT Network@sppirit-network.bsky.social

Join us on March 20th, 3 pm British time for SPPIRIT Forum meeting! We will explore the differences in research of different parasites, from the techniques available to day-to-day lab work, with our invited speakers, covering kinetoplastids, apicomplexans, and schistosoma. Register on link below:

SheinerLab reposted

SheinerLab reposted

Our session explored how studying bioenergetics enzymes via structural biology in divergent protist sheds light on the role of these enzymes and their assemblies across eukaryotes and on how they function in the context of each organisms’ specialised needs.

A first #ICOP25 day 2 highlight: Dayana Salas-Leiva of Ross Waller's lab uses LOPIT to ask not only what makes a symbiotic relationship, but what baggage is left after a break-up. Stay tuned!

Some great models used to study endosymbiosis and what does it take to make a stable relationship: Julius Lukes LOPIT of Insect Trypanosomes reveals new host-endosymbiont interactions Ellen Yeh Epithemia diatoms probes the underlying mechanisms of establishing endosymbiosis

SheinerLab reposted

Happy to have contributed to this wonderful study about #Toxoplasma #supercomplex led by @macleanlab.bsky.social, @sheinerlab.bsky.social and Alex Mühleip. Parasite mitochondria never cease to amaze! Please go checkout 👇

SheinerLab reposted

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Other complex III inhibitors are being developed as drug leads for apicomplexan diseases. Together with Stone Doggett and colleagues at @OHSUNewswe we showed how the drug-lead ELQ-300 binds Toxoplasma complex III and designed a more potent version.

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Atovaquone is a clinically used drug for apicomplexan diseases such as #malaria and #toxoplasmosis, but its precise mechanism of inhibition was unknown. We showed how atovaquone interacts with Toxoplasma complex III and why it is selective to apicomplexan compared to human.

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Respiratory complexes form “super-complexes” whose physiological function is debated, and assembly only studied in a few organisms. We showed that apicomplexan conserved proteins mediate III2-IV supercomplex formation, and that this provides competitive growth advantage.

Inspirational talk from Dr Sharifa Abdulla about how to strike partnerships - think: What is the problem Whose problem is it (and therefore) Who should be engaged in the partnership

A true honour. Thank you to BSP @bspparasitology.bsky.social and our fabulous parasitology community

🏅 | @uofgsii.bsky.social's Professor Lilach Sheiner (@sheinerlab.bsky.social) was recently awarded the prestigious C.A. Wright Medal by the @bspparasitology.bsky.social for outstanding contributions to the discipline. Congratulations, Professor Sheiner! 🔗 Full story: www.gla.ac.uk/schools/infe...

SheinerLab reposted

SheinerLab reposted

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

SheinerLab reposted

Sorry we got blown off by the storm last time but looking forward to going back to Glasgow and talking parasites and brains with an inspiring set of scientists @abhinay.bsky.social @clarehardinglab.bsky.social @maizel-lab.org @sheinerlab.bsky.social

Abhinay Ramaprasad@abhinay.bsky.social

GRiP-ing seminars continue this Friday! Our next speaker is Emma Wilson @toxobrains.bsky.social from @ucriverside.bsky.social. Come, join us! Link: uofglasgow.zoom.us/j/8640933246... Passcode: 719067

SheinerLab reposted

🔊one week left👇

SheinerLab@sheinerlab.bsky.social

📢#Postdoc opportunities: we are looking for two experienced and motivated researcher to join our WT funded projects on the role of the #Toxoplasma #mitochondria during #infection www.jobs.gla.ac.uk/job/research...