Sholto David

Sholto David

@sholtodavid.bsky.social

1.7K followers251 following395 posts

Sholto David reposted

Today I am sharing a new preprint and accompanying blog post. Hundreds of published papers include impossible western blots showing protein expression in cell lines that have deleted or mutated genes. These clumsy mistakes are widespread and repeated by LLMs.

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As an example the PC-3 cell line has a complete deletion of the STAT3 gene. I was able to identify 37 papers that presented a STAT3 western blot in this cell line anyway.

Today I am sharing a new preprint and accompanying blog post. Hundreds of published papers include impossible western blots showing protein expression in cell lines that have deleted or mutated genes. These clumsy mistakes are widespread and repeated by LLMs.

Sholto David reposted

Toxicology and Applied Pharmacology (EiC Lawrence Lash) published a correction for a paper with apparently manipulated images that were “mistakenly placed” by the authors. I’ll poke Elsevier to see if they agree With the journal.

Four of these studies were cited by the European Food Safety Authority's assessment of the safety of Titanium Dioxide as a food additive, although they do not appear to have influenced the result.

Sholto David reposted

Today I'm posting a new video! This case report includes AI generated images. Despite being apparently fabricated with OpenAI tools this paper is already suggested by ChatGPT as evidence to be considered for off label treatment of an autoimmune disease. youtu.be/G9KHwXNIJyk

Fabian Wittmers@academic-integrity.bsky.social

Totally legit comet assay in Elsevier's Environmental Toxicology and Pharmacology (DOI: 10.1016/j.etap.2018.01.007). Spotted this because of @sholtodavid.bsky.social's post on FBS detailing how widespread these fake assays are! pubpeer.com/publications...

Is anyone good at these? Is this photo from a recent Frontiers in Medicine case report AI generated/modified? Anything you can point to specifically? (10.3389/fmed.2026.1915046)

Thanks everyone for helping! I think there's enough here to warrant a transparent analysis from the authors that shows details of exactly what was done. Duplicate value pairs are a good catch and I found a few more.

Retracted today from Scientific Reports following my comments. Graphene oxide against cancer cells. The unlikely collaboration involved authors from Ethiopia, Chile, India, China, and South Korea. Two of the diagrams were easily identifiable as AI slop.

I expect the (obvious) slop schematic window is closing, these diagrams generally look better now. Fun while it lasted! But I still think there are ways to detect AI generated images.

Catching up with MDPI corrections. A published meta-analysis accidentally compared body fat in the probiotic group to weight in the control group. Unsurprisingly comparing two different variables resulted in an obviously wrong forest plot. The authors did correct this after I spotted it.

What will work for pancreatic cancer? Revolution Medicines and their BORING chemistry (YUCK!) or MD Anderson and Lorenzo Cohen with actual MAGIC!

Sholto David@sholtodavid.bsky.social

Good to see that Lorenzo Cohen is still wasting MD Anderson's NIH money on psychic interventions, all peer reviewed of course. From the Materials and Methods: "Briefly, the therapist rapidly cycles through images or symbols of future events they want to have or experience."

Good to see that Lorenzo Cohen is still wasting MD Anderson's NIH money on psychic interventions, all peer reviewed of course. From the Materials and Methods: "Briefly, the therapist rapidly cycles through images or symbols of future events they want to have or experience."

Silly correction at Cell Death & Disease. Authors elected to correct just one of these images after accepting that there was an overlapping area, but disputed the other obviously cloned parts. Who accepted the correction at Springer Nature? Sometimes it feels like there are no adults in the loop.