Stefan Schaefer (@sl-schaefer.bsky.social)

Stefan Schaefer

@sl-schaefer.bsky.social

Computational Biophysicist | interested in protein dynamics, membrane proteins, and novel methods to study them

@sl-schaefer.bsky.social

Played around a bit with Blender over the weekend and made a movie of a computational assay I had set up a while ago. Gasdermin-D binds to PIP lipids and I wanted to know what impact it has to just populate the most prominent binding site. PIP3, even more than PIP2, stabilizes GSDMD oligomers!

Stefan Schaefer

@sl-schaefer.bsky.social

14 Sept

The full story, including experimental data that shows this stabilization with super-res. microscopy is also out by now: doi.org/10.1126/scia...

doi.orgDirect visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosisPI(3,4,5)P3 lipid remodeling during pyroptotic cell death structurally stabilizes GSDMD pores at the plasma membrane.

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