stapleslab.bsky.social

stapleslab.bsky.social

@stapleslab.bsky.social

174 followers261 following23 posts

stapleslab.bsky.social reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: IFI16 senses and protects stalled replication forks Online now:

dlvr.itIFI16 senses and protects stalled replication forksGamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.

stapleslab.bsky.social reposted

Aga Gambus
@agagambus.bsky.social

Last 3 days to apply for this post. Deadline 27/10/25

Aga Gambus@agagambus.bsky.social

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

jobs.ac.ukSenior Research Technician at University of BirminghamExplore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

stapleslab.bsky.social reposted

Alessandro Costa
@costalaboratory.bsky.social

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

crick.wd3.myworkdayjobs.comPostdoctoral Fellow - Costa LabSalary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

stapleslab.bsky.social reposted

Unterholzner Lab
@unterholznerlab.bsky.social

Pre-print alert! Together with @stapleslab.bsky.social and @cejkalab.bsky.social we find that IFI16 binds to stalled replication forks where it acts as innate immune sensor for replication stress, and protects the nascent DNA from degradation. 👇👇

stapleslab.bsky.social@stapleslab.bsky.social

New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social www.biorxiv.org/content/10.1...

biorxiv.orgIFI16 senses and protects stalled replication forksReplication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...
stapleslab.bsky.social
@stapleslab.bsky.social

New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social www.biorxiv.org/content/10.1...

biorxiv.orgIFI16 senses and protects stalled replication forksReplication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...

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