Stem Cell Reports

Stem Cell Reports & other Cell Press journals are inviting submissions for a special issue on New Approach Methodologies (NAMs). The issue will spotlight innovations from organoids, AI, computational models, & more. Submit by 31 March 2027: 👉 https://bit.ly/4wJHX3I ISSCR

Stem Cell Reports Early Career Editor Amy Wong 🇨🇦 is attending the Till & McCulloch Meeting in Vancouver, Canada in November 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports! https://ow.ly/i9Ir50ZXcjm

Stem Cell Reports Editor-in-Chief Janet Rossant is attending the Till & McCulloch Meeting in Vancouver, Canada in November 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports! https://ow.ly/CCHK50ZXc8K

Mark 20 years of iPSC discovery with a special issue of Stem Cell Reports. The journal welcomes original research and perspectives exploring the impact, advances, and future of iPSC science. Submit by 1 December 2026. Learn more 👉 https://bit.ly/4wGN3hd Cell Press ISSCR

Stem Cell Reports is proud to be named the Official Meeting Journal of the Australasian Society for Stem Cell Research (ASSCR) 2026 Annual Scientific Meeting, taking place 9-11 November 2026 at The Glasshouse in Melbourne, Australia. Learn more: https://ow.ly/J0Yq50ZXOwi

As part of the 20th anniversary celebration of iPS cells, we invited leaders in the field to reflect on how the discovery of iPSCs has impacted their own research and the field of stem cell research and its applications more broadly. Listen to the episode 👉 https://ow.ly/omFb50ZVyCt

20 years after the discovery of iPSCs, the story is still being written. In a new Voices piece, scientists reflect on how iPSC technology transformed their research and the frontiers it could open next. https://ow.ly/nJJl50ZUAZy

Stem Cell Reports Early Career Editor Luca Peruzzotti-Jametti is attending the Brayn Conference 2026 in Catania, Italy on 30 September - 2 October. Connect with him there to discuss whether your research is a fit for publishing in Stem Cell Reports! https://ow.ly/vVbb50ZQhCu

Help commemorate 20 years of iPSC discovery by contributing to a special issue of Stem Cell Reports. The journal is seeking original research and perspectives that reflect the impact and future of iPSC science. Submissions are due 1 December 2026. Learn more 👉 https://bit.ly/4wGN3hd

Researchers from the National University of Singapore recently discussed how they identified a new developmental mechanism that contributes to the absence of the nose using stem cell models. Listen to the latest episode of The Stem Cell Report podcast to learn more: https://ow.ly/X7gg50ZfXIw

Listen to the latest episode of The Stem Cell Report podcast to hear how researchers from the National University of Singapore are addressing human craniofacial development using stem cell models 👉 https://ow.ly/5FQ950ZfXzY

👏 Thank you, Martin Pera, for your transformative leadership of Stem Cell Reports. From launching The Stem Cell Report podcast to creating the Early Career Editorial Board & advancing research rigor, Martin helped shape the journal & elevate voices across the community. https://ow.ly/Ng8l50Z7G4O

Check out the paper in @stemcellreports.bsky.social www.cell.com/stem-cell-re... A collaborative effort between researchers at @fraunhoferitmp.bsky.social, @eu-openscreen.bsky.social, @mdc-berlin.bsky.social, and @hhu.de

🎉 Welcome to the newest Early Career Editors of Stem Cell Reports! Their global perspectives will help shape the future of stem cell science and publishing. 🌍Read more: https://ow.ly/Sji850Z7FmI Alessandro Bertero, Shifeng Xue,

Guests on the latest episode of The Stem Cell Report shared reports from Health Canada–regulated Phase I and Phase II trials evaluating freshly cultured umbilical cord–derived MSCs in patients with COVID-19-related ARDS. https://ow.ly/Cnr750Z2u4n

From basic discovery to clinical translation, @ISSCR_org's open-access society journal showcases research shaping the field. @stemcellreports.bsky.social is the Official Meeting Journal of #ISSCR2026. Learn more about the journal and meet the editorial team this July! invt.io/1bxbkyomhe6

In the latest episode of The Stem Cell Report, guest share how their work explores a therapeutic strategy to improve ARDS outcomes using MSCs, which will be important for optimizing and targeting future cellular therapies. Listen to the full episode 👉https://ow.ly/Iytp50Z2sa9

New podcast episode! Guests from The Ottawa Hospital report results from a Health Canada-regulated Phase I and Phase II trials evaluating freshly cultured umbilical cord-derived MSCs in patients with COVID-19-related ARDS. Listen now 👉https://ow.ly/F7e650Z2rZK

Stem Cell Reports is proud to be the official meeting journal of BaCell 3D, taking place 22-24 June, 2026 in Basel, Switzerland. https://www.isscr.org/unaffiliated-events/bacell3d

Online now! Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neurons. https://ow.ly/4WPA50YXPf8

Are human organoids fit for drug discovery? New review explores screening strategies, ML-enabled readouts, and advantages over traditional models, while addressing major challenges like scalability, robustness, throughput, and standardization needed for pharma adoption. https://ow.ly/nBPJ50YXP6z

Online Now! NRG-1 restoration reactivates NPCs and fosters hippocampal repair by supporting neurogenesis, neuronal complexity, synaptogenesis, and remyelination that reverses memory loss in mice with progressive brain demyelination👉 https://bit.ly/4t9sB6K

Stem Cell Reports, ISSCR's open-access, peer-reviewed journal, has been named the Official Conference Journal of the BaCell3D Organoid Conference, taking place 22-24 June 2026 in Basel, Switzerland. Read more 👉 https://ow.ly/Bo7Q50YRJff

Online now in Stem Cell Reports! TOE1 is a β-catenin interacting protein and novel regulator of hematopoietic cell proliferation through PAK2 modulation https://ow.ly/297I50YP49O ISSCR | Cell Press The Gairdner Foundation | SickKids Foundation

Check out this new #organoid research in Stem Cell Reports: MECP2 mutations rewire human embryonic stem cell fate and bias cortical lineage commitment https://ow.ly/N37850YP3V3 ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New paper provides ultrastructural and 3-D features of ventricular-subventricular zone (V-SVZ) neuroblasts in postnatal microminipigs, establishing them as a tractable gyrencephalic model for postnatal neurogenesis. https://ow.ly/gRnc50YKv4L ISSCR | The Gairdner Foundation | SickKids Foundation

Online Now! An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines that enables production of highly functional stem cell-islets suitable for type 1 diabetes cell therapy. https://ow.ly/RUML50YKuVP ISSCR | Cell Press

In this anniversary episode, Janet Rossant is joined by a few of our past guests who helped define the conversations of the past five years. Revisit where their work stood then, explore where it has gone since, & take a closer look at what lies ahead 👉https://ow.ly/WcRv50YJ0Uo

Check out this new intestinal #organoid research: Phenotypic screening identified that glycyrrhizin confers protection against tumor necrosis factor-induced cell death, which may be a novel therapeutic compound for Crohn’s disease. https://ow.ly/VZvQ50YKuMG

New #RareDisease research! Bosma arrhinia microphthalmia syndrome (BAMS) is marked by the absence of a nose and eye/reproductive anomalies, which may result from impaired differentiation to cranial placode cells and changes in cell adhesion. https://ow.ly/kRPX50YGFGl

Stem Cell Reports, ISSCR's open-access, peer-reviewed journal, has been named the Official Conference Journal of the BaCell3D Organoid Conference, taking place 22-24 June 2026 in Basel, Switzerland. Read more 👉 https://ow.ly/mesl50YInK1

Chemotherapy-induced thrombocytopenia (CIT) is a severe complication in elderly cancer patients. New research shows that dietary restriction mitigates CIT in aged mice via mitochondrial potentiation in hematopoietic stem cells and megakaryocyte progenitors. https://ow.ly/VpFm50YEMX5

A nuclear receptor screen identifies Rora as a dose-dependent regulator of cell fate. Transcription factor dosage—not just identity—drives reprogramming efficiency, pointing to nuclear receptor modulation as a lever for cell plasticity https://ow.ly/B4jU50YEN1g

A screen of 49 nuclear receptors identifies the ROR subfamily as OKS (OCT4/KLF4/SOX2) enhancers. Rora acts as a dose-dependent regulator of cell fate, tuning reprogramming efficiency. https://ow.ly/XPlQ50YEMWN Cell Press | The Gairdner Foundation | SickKids Foundation

Stem Cell Reports is pleased to announce the appointment of Hongmei Wang, Ph.D., as an Associate Editor. Dr. Wang is a professor of State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS). Read more 👉https://ow.ly/rfEu50YGw9E

New research from Duke University in Stem Cell Reports uses multimodal human podocyte injury models to discover kidney disease targets, highlighting the predictive power of human-relevant experimental models. https://ow.ly/5gsa50YEMWk Cell Press | The Gairdner Foundation | SickKids Foundation

Online Now! A semi-automated multi-electrode arrays (MEA) spike sorting method for high-throughput assessment of cultured neurons; enhances the resolution & utility of MEA in disease modeling and drug development using hPSC-derived neurons. https://ow.ly/lzkW50YEMVV

Stem Cell Reports is proud to be the official meeting journal for the 20th Annual Wisconsin Stem Cell Symposium! Learn more about the event 👉 https://stemcells.wisc.edu/7376-2/

Thrombopoietin (THPO)-driven neonatal hematopoiesis establishes the hematopoietic stem cell and multipotent progenitor cell hierarchy. While its role is limited in adults, THPO is critical during early development for a structured hematopoietic system. https://ow.ly/sOca50YARe5

New! 3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease, providing platform for mechanistic studies and therapeutic testing. https://ow.ly/XkVS50YALSQ Cell Press | The Gairdner Foundation | SickKids Foundation

Stem Cell Reports announces measures to strengthen scientific rigor with new publication standards today. Advancing transparency, reproducibility, and trust in stem cell science. www.isscr.org/isscr-news/s... @isscr.org @cellpress.bsky.social @sickkidsvs.bsky.social

The challenges of choosing your pluripotent stem cell line. A new letter explores whether to use a “ready-to-use” hPSC line or make a new one, and how that choice impacts suitability for the intended clinical indication and resulting cell types. https://ow.ly/5rCu50YALJY

New review in Stem Cell Reports from CiRA, Kyoto University discusses the developmental origins and functions of microglia, current differentiation approaches, and how these models help elucidate disease-relevant phenotypes and molecular mechanisms in neurodegeneration. https://ow.ly/q8qF50YALC3

Online now: Mechano-electrical stimulation enhances peripheral nerve regeneration by activating and directing neural crest stem cell differentiation, supporting a novel therapeutic approach to stem cell modulation for nerve repair. https://ow.ly/8Ayu50YALtR

Out Now in Stem Cell Reports! A practical framework for hiPSC model development with stem cell-specific guidance on reporting diversity and a four criteria tool (purpose, plausibility, readiness, and power) to determine when and how to incorporate diversity in research.  https://ow.ly/qkSE50YwSug

Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning supporting a model in which fate potential and timing co-regulate the spatial and laminar organization of cortical cell types. https://ow.ly/gjc850YwSjP

New from CiRA in Stem Cell Reports! Deuterosomal cells are the responsible lineage for multiciliogenesis in human airway differentiation. An iPSC-based platform for investigating mechanisms underlying airway multiciliogenesis and modeling primary ciliary dyskinesia. https://ow.ly/8afr50YwSbK

Toward standardized iPSC testing: A multi-year international study highlights variability in flow cytometry (pluripotency) and qPCR (genomic integrity) assays, underscoring the urgent need for harmonized QC to support global adoption of iPSC-derived therapies. https://ow.ly/s1G850YwS6f

Propofol, a common anesthetic, shows region-specific effects in human forebrain organoids, enhancing growth, neuronal excitability, and action potential activity. A new model to study anesthetic impacts on early brain development. https://ow.ly/XGvE50YwRUK