Themistoklis Paraschiakos

Themistoklis Paraschiakos

@themispa.bsky.social

Physician-scientist exploring protein interactions, actin dynamics & synthetic nanobodies. Merging wet lab & bioinformatics. Always curious.

11 followers 30 following5 posts

Themistoklis Paraschiakos reposted

Themistoklis Paraschiakos

@themispa.bsky.social

How do hundreds of proteins grip the cell’s actin skeleton? After 4 years of work, we discovered a tiny, 9-amino-acid conserved motif that acts as a universal molecular anchor—defining a whole new class of actin-binding proteins! Read it here: www.nature.com/articles/s41...

nature.comEvolutionarily conserved short linear motifs drive actin filament binding - Nature Cell BiologyParaschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...

Themistoklis Paraschiakos

@themispa.bsky.social

How do hundreds of proteins grip the cell’s actin skeleton? After 4 years of work, we discovered a tiny, 9-amino-acid conserved motif that acts as a universal molecular anchor—defining a whole new class of actin-binding proteins! Read it here: www.nature.com/articles/s41...

nature.comEvolutionarily conserved short linear motifs drive actin filament binding - Nature Cell BiologyParaschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...

Themistoklis Paraschiakos

@themispa.bsky.social

All sparked by one pattern in a sequence alignment. Huge thanks to everyone involved, especially Biao, Michael, Kostja, and the Windhorst, @linderlab.bsky.social & Marlovits. Very happy to finally share the work!

Themistoklis Paraschiakos

@themispa.bsky.social

How do hundreds of proteins grip the cell’s actin skeleton? After 4 years of work, we discovered a tiny, 9-amino-acid conserved motif that acts as a universal molecular anchor—defining a whole new class of actin-binding proteins! Read it here: www.nature.com/articles/s41...

nature.comEvolutionarily conserved short linear motifs drive actin filament binding - Nature Cell BiologyParaschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...

Themistoklis Paraschiakos

@themispa.bsky.social

Using our computational pipeline (SLiMFold), we found this motif in 103 diverse human proteins. We resolved how it engages actin using biochemistry, cell imaging & cryo-EM. Fun fact: it’s the exact same motif found in LifeAct, the widely used imaging probe!

Themistoklis Paraschiakos

@themispa.bsky.social

How do hundreds of proteins grip the cell’s actin skeleton? After 4 years of work, we discovered a tiny, 9-amino-acid conserved motif that acts as a universal molecular anchor—defining a whole new class of actin-binding proteins! Read it here: www.nature.com/articles/s41...

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