themorrislab.bsky.social

themorrislab.bsky.social

@themorrislab.bsky.social

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themorrislab.bsky.social reposted

Garvin SUMO Biology Lab
@garvinlab.bsky.social

Nice to see this one out in @natcomms.nature.com from @themorrislab.bsky.social, @leneyms.bsky.social, @anoopsinghchauhan.bsky.social, @profstewartlab.bsky.social. Still, plenty of surprises into how RNF168 works! rdcu.be/eiXxy

rdcu.bePIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistanceNature Communications - The ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step...
themorrislab.bsky.social
@themorrislab.bsky.social

How is RNF168 cleared from sites of DNA damage? It’s complicated; www.nature.com/articles/s41...

nature.comPIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance - Nature CommunicationsThe ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step post-translational cascade regulating RNF...
themorrislab.bsky.social
@themorrislab.bsky.social

We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social dlvr.it/TJN3yl @cp-molcell.bsky.social @unibirmingham.bsky.social

dlvr.itSUMO4 promotes SUMO deconjugation required for DNA double-strand-break repairGarvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

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