The Woo Lab

The Woo Lab

@thewoolab.bsky.social

Official Account for Christina Woo’s Lab at Harvard CCB| chembio, protein mods, chemoproteomics, TPD | Student-run account | posts by Christina signed CMW

184 followers42 following18 posts

The Woo Lab
@thewoolab.bsky.social

‼️Important Deadlines‼️📅 Scholarship💰: 14 October 2026 Short Talk Abstract 🎤: 14 October 2026 Poster Abstract 🎨: 19 January 2027 Early Registration ✅: 10 December 2026

The Woo Lab
@thewoolab.bsky.social

The Woo Lab was proud to hood the three PhD’s of the class of 2026! Cheers 🥂 and congratulations 🎉 to Dr. Vanessa Dippon, Dr. Alison Mody, and Dr. Hannah Lloyd! 🫶🏼

The Woo Lab
@thewoolab.bsky.social

We hope you all enjoyed Christina's talk as much as we enjoy sharing our science! Seems like it was a packed house 🫡

Leiden Early Drug Discovery & Development (LED3)@led3hub.bsky.social

We are very happy that Christina Woo (@thewoolab.bsky.social) visited us for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation. #TPD #ChemBio #ChemSky

The Woo Lab
@thewoolab.bsky.social

Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...

nature.comSmall molecule splicing modulators that disrupt O-GlcNAc homeostasis - Nature CommunicationsAuthors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These ...
The Woo Lab
@thewoolab.bsky.social

Another Woo Lab Dr. is in: Congrats to our newest Ph.D, Dr. Alison Mody!🫡 Cheers to a wonderful Ph.D. and a sweet (pun intended) thesis talk, all the world’s alpacas are celebrating with you in spirit 🦙🩵🟦💐🎉

The Woo Lab
@thewoolab.bsky.social

we hope you enjoyed this paper as much as we do! 😉😘 if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD

The Woo Lab@thewoolab.bsky.social

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

The Woo Lab
@thewoolab.bsky.social

While allostery is biochemical cooperation, this was an epitome of scientific collaboration💙. We'd like to thank our collaborators at GSK and the Lander Lab at Scripps, without whom this work would not have been possible 💙💐🤝

The Woo Lab
@thewoolab.bsky.social

He’s gonna be gonna be golden! ⭐️ While we’re sad that our beloved postdoc, Dr. Zhenguang Zhao, is leaving, we’re excited for his next steps as he becomes Prof. Zhao at China Pharmaceutical University! 🤩✨🌟

The Woo Lab
@thewoolab.bsky.social

wow! Thanks for the shoutout 🥹 Hopefully our papers in the coming year will continue to impress 😉 stay tuned!!

Stephan Hacker@stephanhacker2.bsky.social

Cereblon is one of the most used E3 ligases for degraders. After showing that C-terminal cyclic imids on proteins are ligands for cereblon, the @thewoolab.bsky.social showed that PCMT1 can install them on asparagines via SAM-dependent methyl ester formation. (5/12) www.nature.com/articles/s41...

nature.comPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical BiologyThe enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...

The Woo Lab reposted

Stephan Hacker
@stephanhacker2.bsky.social

Last paper post of the year! Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon. www.nature.com/articles/s41... #ChemSky #ChemBio #TPD

nature.comPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical BiologyThe enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...
The Woo Lab
@thewoolab.bsky.social

We’re popping the champagne prior to New Year’s because our work on how PCMT1 enzymatically forms the CRBN degron is officially out in Nature ChemBio🥂!! Congrats to Zhenguang, Wenqing, Ethan, Shiyun, and all the authors! 🎉💜🍾 www.nature.com/articles/s41...

nature.comPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical BiologyThe enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...
The Woo Lab
@thewoolab.bsky.social

Let us take you to the land of sweets with our latest work in @CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538

The Woo Lab
@thewoolab.bsky.social

After some ~technical difficulties~ the Woo Lab is officially (back) on BlueSky!! Apologies for ignoring all the love for the past month 😅 Excited to share some exciting science on this platform 😉✨💜

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