Torben Ott

Torben Ott

@torbenottlab.org

🧠Neuroscientist | 🎓PI Decision Circuits Lab at Humboldt University and Bernstein Center Berlin, Germany | experiment🔗theory | #behavior #dopamine #serotonin #psychedelics 🌐 https://torbenottlab.org

223 followers127 following9 posts

Torben Ott reposted

The vOICe vision BCI 🧠🇪🇺
@seeingwithsound.bsky.social

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise (in mice) www.biorxiv.org/content/10.6... by @roberto-defilippo.bsky.social @torbenottlab.org et al.

biorxiv.orgPsilocybin collapses visual change detection and drives cortical dynamics toward a state of surprisePsilocybin profoundly alters visual perception, yet the neuronal mechanisms underlying these effects remain unclear. Here we combined large-scale Neuropixels recordings with cell-type-specific optogen...
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Torben Ott
@torbenottlab.org

4/ Unexpectedly, psilocybin's effect were not global or uniform but dependent on the image structure: Only images with long, continuous contours recruited change-encoding neurons that were modulated by psilocybin.

Torben Ott
@torbenottlab.org

5/ Our findings point to a previously unrecognized role for SST interneurons in the acute psychedelic state, potentially linking altered surprise signals to visual distortions. A huge thank-you to the entire OpenScope team, especially @jeromelecoq.bsky.social, for making this work possible!

Torben Ott
@torbenottlab.org

2/ We found a striking behavioral effect: psilocybin reduced change-detection performance to chance, without causing obvious motor deficits. At the same time, visual stimuli drove a strong 4-Hz oscillation across visual cortex, especially in VISp and SST interneurons.

Torben Ott
@torbenottlab.org

3/ Surprisingly, despite this oscillation, image id encoding was completely intact! By contrast, this oscillation was closely linked to CHANGE encoding, pushing visual cortex dynamics in SST interneurons towards states usually associated with surprise.

Torben Ott reposted

Peter Kok
@peterkok.bsky.social

Our study using layer fMRI to study the direction of communication between the hippocampus and cortex during perceptual predictions is finally out in Science Advances! Predicted-but-omitted shapes are represented in CA2/3 and correlate specifically with deep layers of PHC, suggesting feedback. 🧠🟦

science.orgCommunication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortexHigh-resolution neuroimaging reveals stimulus-specific predictions sent from hippocampus to the neocortex during perception.

Torben Ott reposted

Jacob Bakermans
@bakermansjjw.bsky.social

Happy to share the latest version of our work on compositional maps in hippocampus with Jo Warren, @jcrwhittington.bsky.social, @behrenstimb.bsky.social. We propose hippocampus constructs maps from cortical building blocks in replay – now with empirical support! www.nature.com/articles/s41... 1/9

nature.comConstructing future behavior in the hippocampal formation through composition and replay - Nature NeuroscienceA model of compositional state spaces in the hippocampus shows latent learning and rapid generalization. Bakermans et al. show that this model predicts the emergence of place responses in replay.

Torben Ott reposted

ari ☀️
@khoudary.bsky.social

super excited that the first paper from my PhD is now out! we develop a "philosophical toolkit" for computational cognitive modeling & use it to conceptually re-analyze a long-standing debate about evidence accumulation models of decision making 🧠📈 onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.comReasoning Goals and Representational Decisions in Computational Cognitive Neuroscience: Lessons From the Drift Diffusion ModelThe appropriate form of the drift diffusion model depends on how one wishes to reason about their target with the model. If the goal is to parsimoniously explain the speed-accuracy tradeoff, the appr...

Torben Ott reposted

Josh Johansen
@jojolab.bsky.social

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8) rdcu.be/el19t

rdcu.bePrefrontal encoding of an internal model for emotional inferenceNature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.

Torben Ott reposted

Paul Frankland
@franklandlab.bsky.social

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

rdcu.beSystems consolidation reorganizes hippocampal engram circuitryNature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Torben Ott reposted

Helen Barron
@helencbarron.bsky.social

*** Come join us !! We are recruiting !! *** How does the brain generate beliefs that go beyond direct experience? How do these mechanisms go awry in psychosis? The Barron lab tinyurl.com/bdf4drjf @MRCBNDU @NDCNOxford are recruiting a new postdoc tinyurl.com/ut4vbwt4 to work in mouse models

tinyurl.comBarron Group | mrcbnduOur group investigates how cells and circuits in the brain work together to perform computations that support memory. Using a wide range of technical approaches, we investigate how these computations ...

Torben Ott reposted

Emerson Harkin
@efharkin.bsky.social

I'm excited to share that the last chapter of my PhD thesis is now published in Nature! 🍾 What drives serotonin neurons? We think it's the expectation of future reward and --- critically --- how fast this expectation is increasing. 📈 doi.org/10.1038/s415... 1/6

doi.orgA prospective code for value in the serotonin system - NatureMerging ideas from reinforcement learning theory with recent insights into the filtering properties of the dorsal raphe nucleus, a unifying perspective is found explaining why serotonin neurons are ac...

Torben Ott reposted

Science Magazine
@science.org

"Academics tend to be averse to discussing mental health openly, and higher education’s mental health safety net is patchy—a forgotten footnote that all too often fails its students." #MentalHealthAwarenessMonth scim.ag/4m61iaU

Torben Ott reposted

Jascha Achterberg
@achterbrain.bsky.social

Super interesting work with a computational model of how auditory hallucinations may arise: journals.plos.org/plosbiology/... #neuroscience #compneuro

journals.plos.orgImpaired motor-to-sensory transformation mediates auditory hallucinationsCan the absence of inhibition lead to auditory hallucinations? This study shows that the impairment of motor-based sensory predictions causes erroneous monitoring of imprecise internal auditory repres...

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