VectorBuilder

Institute for Human Genetics at UCSF

This May, the VectorBuilder team is heading to key conferences across the globe! 🌍 Come meet our team and learn how our research and CDMO solutions are helping accelerate breakthroughs.

VectorBuilder reposted

@ihgatucsf.bsky.social

30 Apr

Take a break and have lunch with @vectorbuilder.bsky.social :) humangenetics.ucsf.edu/lunch-and-le...

4 May

Tired of the clone wars? VectorBuilder’s got your back. Check out our Vector Design Studio and use our stable cell line engineering service to find the cells you’re looking for. Happy Star Wars Day, and may the force be with you!

1 May

It's the final day of CDMO Week 🧬 The conversation doesn’t stop here, this is just the beginning for what’s next in gene delivery!

30 Apr

Day 4 of #CDMOWeek 🧬 Juggling vector design, optimization & manufacturing? 😵‍💫 VectorBuilder helps you do it all, end to end 🚀 From vector design to GMP, all in one place (no chaos). Talk to the CliniVec™ team today for a free consultation!

nytimes.comHow to Turn a Chicken Egg Into a Drug Factory

29 Apr

For day three of our #CDMOWeek, we’re sharing a recent article from the @nytimes.com highlighting how our customers at Neion Bio are rethinking biologics manufacturing, developing chicken-based systems that aims to use eggs as platforms for drug production. www.nytimes.com/2026/03/26/s...

29 Apr

Instead of traditional cell culture, their approach focuses on engineering This exciting approach could offer a simpler, more scalable, and more affordable way to produce complex biologics. We can't wait to see the next steps!

en.vectorbuilder.comVectorBuilder | Revolutionizing Gene Delivery.A free-to-use tool for scientists to design and order custom DNA vectors. Select promoters/ORFs from our database or enter your own sequences.

29 Apr

Interested in avian embryo models? Explore our RCAS vectors for replication-competent gene delivery and stable expression. en.vectorbuilder.com/resources/ve...

28 Apr

It's Day 2 of #CDMOWeek! Meet the VectorBuilder team at #ISCT2026 in Dublin, Ireland! Be sure to stop by Booth 1905 to learn how VectorBuilder is supporting cell and gene therapy development and translational research from our latest array of products and services.

27 Apr

It’s day 1 of #CDMOWeek 🧬 VectorBuilder is a full-service CDMO supporting every stage of gene therapy—from vector design to GMP manufacturing and QC. Hear from our Head of CDMO Operations, Dr. Alan Griffith, on how we can support your pipeline 👇

20 Apr

☀️VectorBuddy and the VectorBuilder team are in sunny San Diego for @theaacr.bsky.social annual conference, #AACR2026! We are excited to discuss our newest offerings and services to support your cancer research, so be sure to check out Booth 4153.

17 Apr

Are you ready to kick-off #IMMUNOLOGY2026 ? The VectorBuilder team is excited to join the American Association of Immunologists (aai.org) at their annual IMMUNOLOGY conference in Boston. 🗓️ April 15-19, 2026 📍Booth 427 - Thomas M. Menio Convention & Exhibition Center Hall A

Our new preprint introduces MuteFree™ AAV, a high-stability vector system designed to address ITR instability, a common challenge in gene therapy development. The manuscript is now available on bioRxiv. www.biorxiv.org/content/10.6...

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MuteFree™ AAV preserves ITR integrity through optimized plasmid design, enabling consistent, high-fidelity AAV production within standard workflows. By improving stability at the source, it supports more reliable and scalable gene therapy manufacturing.

Will you be at the @asgct.bsky.social Annual Meeting? Join us at the Tools and Technology Forum, where Dr. Bruce Lahn will present “From Research to Clinic: A Practical Guide to Optimizing Therapeutic Vector Design.”

ITR mutations, found in ~40% of AAV transfer plasmids, can reduce yield, introduce variability, and impact therapeutic performance.

13 Apr

VectorBuilder is pleased to exhibit at British Society for Gene and Cell Therapy’s Annual Conference 2026 (bsgct.bsky.social). Have a chat with Christina McClure and Tasnim Hussain to learn about our latest offerings and services for your research and therapeutic development projects.

nature.comNeuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis - Nature AgingYoung, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability...

13 Apr

Alzheimer’s disease develops before symptoms appear, but early brain changes are not fully understood. New work from the Misha Zilberter lab shows APOE4 drives neuronal hyperexcitability in mice and identifies Nell2 as a mediator. CRISPRi KD of Nell2 normalized activity, pointing to an early target.

Misha Zilberter@mzilberter.bsky.social

Our paper is now online at @nataging.nature.com! Alzheimer’s disease begins decades before symptoms—but what drives those earliest changes is still not well understood. We set out to understand how APOE4 disrupts neuronal and network function across aging. 🧵: 1/15 www.nature.com/articles/s43...

10 Apr

For the scientists who know good science and good style go hand in hand 🧬 Coming soon… and yes, you’ll definitely want some.

9 Apr

To celebrate 12 years of VectorBuilder, we’re making it easier to get your next few projects off the ground! We’ve set up a ""Savings Roadmap"" that scales with your research: 1st Order: 20% OFF (Code: Thankyou1st) 2nd Order: 15% OFF 3rd Order: 10% OFF

hubs.laVectorBuilder | Revolutionizing Gene Delivery.A free-to-use tool for scientists to design and order custom DNA vectors. Select promoters/ORFs from our database or enter your own sequences.

9 Apr

Whether you need a complex vector design or a high-titer virus, we are here to help you! New and existing customers (with <3 orders) are eligible to join the innovation assembly line. Activate your savings pass now: hubs.la/Q0483HlC0

8 Apr

Francis Enane@fenane.bsky.social

Interested in learning about the next wave of medicines? Register for this seminar as we discuss the promise of #mRNATherapy as alternative to #ViralBased #GeneTherapy. We will cover a wide range of applicable therapy areas and #translationalstrategies.#raredisease #Cancer #LNP #PrecisionMedicine

7 Apr

Viruses deserve better PR 🦠 Inspiration: @rspbscotland.bsky.social

7 Apr

Viruses deserve better PR 🦠 (cont.)

3 Apr

Trying to figure out if mosaic screening is right for your cancer research? Dr. James Allen, HHMI Hanna Gray Fellow & incoming faculty at Mayo Clinic, highlights mosaic screening approaches in zebrafish and its applications to discovering genetic interactions that contribute to pediatric leukemia.

3 Apr

Check out the full seminar here! youtu.be/0DgvIUSo3wY

youtu.beyoutu.be

2 Apr

mRNA is moving beyond vaccines, but where is it going next? Join our next Gene Delivery Seminar to learn how advances in mRNA design are enabling precise, transient protein expression across diverse disease areas.

us06web.zoom.usWelcome! You are invited to join a webinar: Gene Delivery Seminar: Francis Enane, PhD. After registering, you will receive a confirmation email about joining the webinar.From Blueprint to Biology: Designing Transient mRNA Therapeutics for Next‑Wave Medicine. mRNA is moving beyond vaccines, emerging as a powerful platform for precise, transient protein expression acr...

2 Apr

Dr. @fenane.bsky.social will highlight advances in mRNA design and stability, including optimized UTRs, nucleoside modifications, and emerging modalities like sa-RNA and circ-RNA. You’ll also learn how new LNP technologies are unlocking tissue-targeted delivery! Register now to save your spot:

1 Apr

99% of grad students agree: cloning is their favorite technique. The other 1% are still troubleshooting. …okay fine, we made that up. Happy April Fools’ Day! Leave the cloning to us 🧬

31 Mar

This April, the VectorBuilder team is heading to key conferences across the globe! 🌍 Come meet our team and learn how our research and CDMO solutions are helping accelerate breakthroughs.

dlvr.itIn vivo production of an anti-HIV antibody in mice by non-viral gene knock-in in primate hematopoietic stem and progenitor cellsDeveloping therapies that support long-lasting immunity is challenging to treat HIV. Adair and colleagues demonstrate that antibody-encoding genes can be precisely inserted into the genome of macaque hematopoietic stem cells without viral vectors. When transplanted into mice, these stem cells mature into antibody-producing B cells capable of neutralizing HIV infection.

31 Mar

HIV requires lifelong treatment to maintain viral control, driving interest in approaches that enable sustained anti-HIV antibody production. New work from Jack Castelli, PhD and the Adair lab shows CRISPR knock-in in primate HSPCs enables long-term antibody production in vivo.

Molecular Therapy Family of Journals@moltherapy.bsky.social

27 Mar

Still paying for molecular biology software? VectorBee is the forever-free platform for vector design, editing, annotation, and analysis. No more paywalls, because your research deserves better! Try VectorBee today: hubs.la/Q048fYHx0

26 Mar

Happening today! 🧬 Join today’s Gene Delivery Seminar to learn how you can optimize your lentiviral vectors for reliable gene delivery!

VectorBuilder@vectorbuilder.bsky.social

🧬 What makes lentivirus such a powerful gene delivery tool? Join our next Gene Delivery Seminar to learn how you can optimize lentiviral vectors for stronger performance in your research and clinical applications.

25 Mar

People are buzzin’ about VectorBee! 🐝 Researchers like Dr. Zubair Khalid @zubairkhalidphd.bsky.social are exploring how VectorBee can support their workflows in the lab. Our goal is to make research tools more accessible, without subscriptions, locked features, or limitations.

25 Mar

We love hearing how VectorBee is helping scientists and are constantly working to improve its features. Check out the latest upgrades in VectorBee 3.0: 🐝https://hubs.la/Q048fYHS0

23 Mar

Going to #CDU2026? Our team will be excited to chat at CRISPR Down Under in Melbourne next week. 🧬 Stop and chat with Dr. Chee Ho H'ng (Territory Manager) to learn more about the new CRISPR and research solutions we can support for your research. See you there!

us06web.zoom.usWelcome! You are invited to join a webinar: Gene Delivery Seminar: Skye Storrie. After registering, you will receive a confirmation email about joining the webinar.Engineering Effective Lentiviral Vectors: Selection, Design, and Optimization for Research and Therapy This seminar examines the key attributes that make lentivirus a powerful and widely used gene de...

19 Mar

Successful gene delivery starts with choosing the right vector 🧬 Our next Gene Delivery Seminar is one week away and will focus on strategies to optimize lentiviral vector production and performance in your research. Reserve your spot here: us06web.zoom.us/webinar/regi...

VectorBuilder@vectorbuilder.bsky.social

18 Mar

🐝 What should every student learn about vector design? In this last video, Dr. Shirley Coomber explains how VectorBee helps students understand the core elements of plasmid design, from selecting promoters to building functional expression vectors.

vectorbee.comVectorBee | Comprehensive Vector Design with Unlimited CustomizationVectorBee is a free molecular biology software featuring a user-friendly interface that enables users to easily design, edit, and analyze DNA/RNA sequences filing in .vbee.

18 Mar

Tools like VectorBee help students visualize and apply these concepts, turning vector design into an interactive learning experience. Download VectorBee, forever free, and start designing your own vectors: vectorbee.com/en/

17 Mar

🐝 We recently visited Dr. Shirley Coomber’s Molecular Biology Research Skills workshop at King's College London to see how students are learning vector design with VectorBee.

17 Mar

During the session, students constructed plasmids step by step while exploring biological analysis tools. They then used these skills to design an E. coli expression vector for a gene of interest before moving into the practical lab.

17 Mar

It was inspiring to see how VectorBee transforms vector design from a theoretical concept into an interactive learning experience. Stay tuned for our last VectorBee in Education video, where Dr. Coomber explains the key elements students need to understand when designing vectors.

16 Mar

🐝 Did you know VectorBee is helping train the next generation of scientists? In this first video, Dr. Shirley Coomber shares how she uses VectorBee to teach plasmid design in her Molecular Biology Research Skills course @kingscollegelondon.bsky.social

16 Mar

By designing expression vectors for genes of interest in a computer-based exercise, students prepare to move from theory to applying those skills in the lab and future research. VectorBee is a forever-free tool built to support molecular biology education worldwide.

16 Mar

Stay tuned for our next video, where we visit the classroom to see how students are using VectorBee! Download VectorBee and try it yourself: www.vectorbee.com/en/

13 Mar

Fine-tune your coding sequences with VectorBee 3.0. Choose CDS translation, select reading frames, display labels on vector and sequence maps, and preview predicted protein size. 🐝 Try VectorBee, forever free: www.vectorbee.com/en/

us06web.zoom.usus06web.zoom.us

12 Mar

Why does lentivirus remain one of the most widely used gene delivery platforms? 🧬 In our upcoming Gene Delivery Seminar, you’ll learn about the features that make lentiviral vectors so effective and how you can optimize them for your research. Register here: us06web.zoom.us/webinar/regi...

VectorBuilder@vectorbuilder.bsky.social

12 Mar

Work with your enzymes, your way. Quickly identify restriction sites for selected enzymes using the new Enzyme List Visualization feature and run more interactive gel simulations in VectorBee 3.0 🐝 Try VectorBee, forever free: www.vectorbee.com/en/

11 Mar

Experience the smoothest sequence alignments with VectorBee 3.0. You can now edit chromatogram samples directly within alignment projects, with improved visualization and chromatogram–sequence interaction. Plus expanded import options, alignment draft saving, and sample information editing.