Vern Dolinsky

Incretin hormones GLP-1 and GIP connect #metabolism and cardiovascular #health. Our new REVIEW highlights the latest about how endogenous incretins shape cardiometabolic disease @dream-diabetes.bsky.social @um-pharmacology.bsky.social @um-radyfhs.bsky.social cdnsciencepub.com/doi/10.1139/...

🌟New Member Announcement🌟 We’re excited to welcome Dr. Payam Peymani to the team! His research examines the use, safety, effectiveness, and long-term health effects of #medications with a focus on #pregnancy, #maternal and child health, and emerging treatments for #obesity and type 2 #diabetes.

Influence of maternal #obesity, gestational weight gain and gestational #diabetes on offspring (n=238) metabolites: Positive association with lipid profiles up to 2 years of age #DOHaD www.sciencedirect.com/science/arti...

Maternal BMI and Gestational Weight Gain are association with increased risk of early-onset cardiovascular disease in offspring: Swedish national registry cohort (n=2.5M) #DOHaD #pregnancy #obesity jamanetwork.com/journals/jam...

A retrospective cohort study of n=50,000 births in China highlights greater body length and weight in the first 6 years of life. #DOHaD www.frontiersin.org/journals/end...

Introducing the second keynote speaker for the 15th Annual DREAM Symposium: New Perspectives in Diabetes, Dr. Dylan Burger from @uottawa.ca! Mark your calendars for Nov 5! More info: tinyurl.com/msa657rp Register here: forms.office.com/r/aAeqTaiS0z #diabetes #research #type2diabetes #type1diabetes

DREAM co-lead @verndolinsky.bsky.social and PhD student Khushali Trivedi attended the Canadian Lipid and Vascular Summit last week in Edmonton, AB. Dr. Dolinsky presented the 2026 Simon Pierre Noël Lecture and Khushali received the PhD Oral Presentation Award. Congrats! Making the DREAM theme proud!

The Type 1 Diabetes Exercise and Mentorship (TEAM) Trial is recruiting teens living with type 1 diabetes in Winnipeg and Mississauga. This 12-week peer mentorship + physical activity program aims to improve physical activity and quality of life while reducing diabetes-related distress: teamtrial.ca

Metabolites co-correlating with maternal #obesity and gestational weight and offspring obesity: a prospective birth cohort www.sciencedirect.com/science/arti...

Genes with epigenetic alterations in human pancreatic islets impacts #mitochondria function, #insulin secretion and type 2 #diabetes @natcomms.nature.com @dreamdiabetes.bsky.social pmc.ncbi.nlm.nih.gov/articles/PMC...

#Mitochondria and protein homeostasis pathways are transcriptionally impaired in islets during type 1 #diabetes pathogenesis www.biorxiv.org/content/10.6...

Maternal #exercise is associated with enhanced systolic reserve and altered #mitochondria respiration in adult female offspring #DOHaD @apspublications.bsky.social journals.physiology.org/doi/full/10....

Due to my role at the Terry Fox Research Institute I no longer comment publically on CIHR but this largest funder of Canadian health research made an important statement today: cihr-irsc.gc.ca/e/54795.html and I can’t just watch this beloved agency crash.

New paper from the lab! 🎉 reliable antibodies are the cornerstone of our work! New studies by Jasmine in our group identified a reliable antibody for detecting notoriously difficult cell cycle protein p16INK4a in mouse and human! www.tandfonline.com/doi/full/10.... @dreamdiabetes.bsky.social

Congrats to Dr. Samantha Pauls on being featured by @um-radyfhs.bsky.social! Her research explores how immune cell #metabolism drives chronic inflammation, with the goal of developing new strategies to prevent diseases like type 2 #diabetes and cardiovascular disease👏 umtoday.ca/stories/infl...

Cross-sectional study from the UK Biobank (n=half a million) highlighting the importance of examining cardiometabolic risk in the context of socioeconomic differences and sex @dreamdiabetes.bsky.social bmjpublichealth.bmj.com/content/4/2/...

Maternal butyrate administration ameliorates fetal fatty liver and maternal #obesity metabolic alterations #DOHaD www.sciencedirect.com/science/arti...

REVIEW: Mommy Issues: How Maternal Diet Shapes Offspring #Mitochondria Physiology #DOHaD academic.oup.com/jas/article/...

REVIEW: Intergenerational #obesity prevention through nanogenomic targeting of gestational #diabetes epigenetics @dohadcanada.bsky.social www.sciencedirect.com/science/arti...

Review: Maternal #nutrition may help break the intergenerational cycle of #obesity. Dietary strategies from fiber and omega-3s to probiotics and vitamins can improve offspring health. @dohadcanada.bsky.social link.springer.com/article/10.1...

#Cardiac energy #metabolism in #diabetes: emerging therapeutic targets and clinical implications @dreamdiabetes.bsky.social @apspublications.bsky.social journals.physiology.org/doi/full/10....

Addressing bioenergetic deficits and restoring #mitochondria health in transplanted islets using mesenchymal stem cells @dreamdiabetes.bsky.social academic.oup.com/stcltm/artic...

Early #pregnancy Triglyceride-glucose index as a predictor of gestational #diabetes: Evidence from prospective cohort study (n=870) @FrontEndocrinol www.frontiersin.org/journals/end...

REVIEW: How the first 9 months shape the rest of your life: Impact of gestational #diabetes on the metabolic future #DOHaD @dohadcanada.bsky.social @dreamdiabetes.bsky.social dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

The impact of maternal metabolic flexibility during gestation on infant adiposity in individuals (n=47) with #obesity #DOHaD @apspublications.bsky.social journals.physiology.org/doi/full/10....

The Next Generation Study is exploring why type 2 #diabetes affects some First Nation families across generations. #DOHaD Exposure to diabetes during #pregnancy influence child development, long term #health. Aim is to improve prevention efforts and early treatment. Learn More: tinyurl.com/3zc2tydz

Skeletal muscle #mitochondria bioenergetics in #pregnancy in a comparison of in vivo and in vitro outcomes shows that mitochondrial adaptations to aerobic exercise are blunted in late pregnancy (n=10 women) academic.oup.com/jes/article/...

Short-term time-restricted feeding improves metabolic rhythms and liver #mitochondrial bioenergetic function in high-fat diet-fed mice @apsphysiology.bsky.social @chrisadoucette.bsky.social journals.physiology.org/doi/full/10....

The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse #Heart too @chrisadoucette.bsky.social journals.physiology.org/doi/full/10....

Single cell analysis of human pancreatic islets (n=48 donors) reveals increased population of senescent beta cell population and 511 differentially expressed genes in type 2 #diabetes Integration with proteomic/mouse model data reveals 58 candidate genes link.springer.com/article/10.1...

Celebrating 10 years of DOHaD Canada! 🎉 Our 2026 Annual Scientific Meeting brought together outstanding trainees, researchers, and speakers to explore the biological and psychosocial foundations of lifelong health. Thank you to everyone who attended. @kconnor.bsky.social #DOHaDCanada2026

Retrospective cohort study: Detection of young-onset type 2 #diabetes using deep learning across primary and secondary care: Nationwide study from Denmark (n=16828 youth-onset T2D population) @thelancet.com @dreamdiabetes.bsky.social www.thelancet.com/journals/lan...

REVIEW: #Metabolic syndrome and #kidney dysfunction: emerging molecular and cellular mechanisms at the metabolic–renal interface #mitochondria @dreamdiabetes.bsky.social www.frontiersin.org/journals/end...

📅Save the Date! The 15th Annual DREAM Symposium: New Perspectives in Diabetes will be held on Nov 5 and the DREAM Trainee Day on Nov 4 in Winnipeg, MB. More info and abstract guidelines: tinyurl.com/msa657rp Abstracts due Sept 9. Register here: forms.office.com/r/aAeqTaiS0z @chrimanitoba.bsky.social

REVIEW: #Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for #diabetes @dreamdiabetes.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

REVIEW: #Heart Failure in Type 1 vs. Type 2 #diabetes Shared Pathways, Distinct Challenges onlinelibrary.wiley.com/doi/10.1155/...

REVIEW: #Proteomics of the #heart @apspublications.bsky.social journals.physiology.org/doi/full/10....

Functional validation of a non-canonical HNF1B splice-site variant in MODY5 #diabetes www.frontiersin.org/journals/end...

Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model #diabetes @dreamdiabetes.bsky.social @chrisadoucette.bsky.social insight.jci.org/articles/vie...

Maternal #obesity alters adipogenic potential and #mitochondrial maximal respiration in infant mesenchymal stem cells #DOHaD @dohadcanada.bsky.social www.frontiersin.org/journals/end...

Really cool study showing the single-cell multiomic atlas of #stemcell #islet differentiation. #diabetes Pre-print from bioRxiV: www.biorxiv.org/content/10.6...

Cross-ancestry analysis of gestational #diabetes in British, Finnish and Chinese populations identifies novel loci and biological pathways www.frontiersin.org/journals/end...

Better late than never! 2025 was another fantastic year for the @dreamdiabetes.bsky.social theme. Let’s look back and highlight some important achievements and successes from #2025 in no particular order (🧵1/9):

Only 2 more days! Don't miss the April 30 deadline for early bird registration for the great DOHaD Canada Meeting. A great opportunity to network and share knowledge. See you in London Ontario!! #DOHaD #epigenetics #pregnancy #biology

BBDC member @danieljdrucker.bsky.social discusses his research in the latest University of Toronto Magazine. Read the story now! magazine.utoronto.ca/research-ide...

i’d suggest a footnote. but i’d also strongly suggest not using it. applicants: please do your own reading of papers & thinking about research plans. discuss with colleagues, students and fellows. it’s really fun & rewarding to interact with humans & to be collectively creative

On March 23, 2026, the iCARE Participant Advisory Group began expanding nationally, welcoming three patient partners from Ontario iCARE sites for the first time for an arts-based workshop on advancing youth and family partnership in equitable, patient-centred type 2 diabetes research.

DREAM researcher Dr. Brandy Wicklow was recently featured on @ctvnewswinnipeg.bsky.social, where she shared insight on the growing type 2 diabetes crisis among youth in Manitoba—especially in First Nations communities. Watch here: www.ctvnews.ca/winnipeg/vid... @chrimanitoba.bsky.social #diabetes

TOMORROW don't miss hearing from Suresh Mishra about his research

GPR146 in #fat tissue drives adipose-liver crosstalk by increasing adipogenesis and lipolysis. Reducing GPR146 protects against hepatic steatosis in mice #obesity @natcomms.nature.com www.nature.com/articles/s41...