Xin Gu Lab at DFCI/HMS

Xin Gu Lab at DFCI/HMS

@xingulab.bsky.social

Enthusiastic about transcription factor turnover!

60 followers35 following13 posts

Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social

Super grateful for this generous support for my lab! And excited to make more cool discoveries!

Dana-Farber News@danafarbernews.bsky.social

Congratulations to @danafarber.bsky.social’s @nickpolizzi.bsky.social and Xin Gu, PhD, recipients of NIH New Innovator Awards supporting early career investigators pursuing highly innovative research with potential for broad impact on biomedical and behavioral science. ➡️bit.ly/4hKLs46

Xin Gu Lab at DFCI/HMS reposted

Ronald Breaker
@ronbreaker.bsky.social

My lab at #Yale has two #riboswitch research openings: 1. Postdoc with mammalian gene manipulation experience (tinyurl.com/zzb269em); 2. Postdoc (or BS, MS) with bioinformatics skills (tinyurl.com/3j73jfcn). Send your cv to me or to Kavita at kumari.thakur@yale.edu.

tinyurl.comPostdoctoral Associate in Eukaryotic Cellular Molecular Genetics and RNA Biology — Department of Molecular, Cellular and Developmental Biology (MCDB)
Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social

Incredibly grateful for the generous support from @pew.org !! So excited to be part of this awesome community!

Dana-Farber News@danafarbernews.bsky.social

Congratulations to @danafarber.bsky.social’s Xin Gu, PhD, on being named a 2026 Pew Scholar in Biomedical Sciences. As a Pew Scholar, Gu will study a newly discovered pathway that cells use to selectively break down proteins that regulate gene activity. ➡️bit.ly/3SjUfB4

Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social

Super excited to contribute to this special interest subgroup!!! Thank you for this opportunity, Abby and Iain!

Abby Buchwalter@abbybuch.bsky.social

It's an amazing time to be a cell biologist, as new tech makes probing cellular processes in physiological contexts more tractable. This is the theme of a Special Interest Subgroup that @iaincheeseman.bsky.social and I are hosting at #cellbio2025. Join us on Saturday 12/5! @ascbiology.bsky.social

Xin Gu Lab at DFCI/HMS reposted

Harvard Med Cell Biology
@harvardcellbio.bsky.social

New work from @xingulab.bsky.social @sshaolab.bsky.social & Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation. www.cell.com/molecular-ce...

cell.comStructural basis for the midnolin-proteasome pathway and its role in suppressing myelomaNardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable...
Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social

So happy and proud to see our story online!! Thank you, the midnolin team!

Molecular Cell@cp-molcell.bsky.social

Online Now: Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma Online now:

dlvr.itStructural basis for the midnolin-proteasome pathway and its role in suppressing myelomaNardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable a unique form of ubiquitination-independent proteolysis. This study also unveils midnolin downregulation as a key driver of multiple myeloma through the aberrant stabilization of IRF4.

Xin Gu Lab at DFCI/HMS reposted

Susan Shao
@sshaolab.bsky.social

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay Come join us for a fun time and invigorating scientific discussions in Vienna! meetings.embo.org/event/25-rna...

meetings.embo.orgRNA meets protein decayEstablishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

Xin Gu Lab at DFCI/HMS reposted

Susan Shao
@sshaolab.bsky.social

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

Xin Gu Lab at DFCI/HMS@xingulab.bsky.social

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...

biorxiv.orgStructural basis for the midnolin-proteasome pathway and its role in suppressing myelomaThe midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...

biorxiv.orgStructural basis for the midnolin-proteasome pathway and its role in suppressing myelomaThe midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...

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