Yassi Aghazadeh

Congratulations are in order for Usama for finishing his M.Sc. at @mcgill.ca Experimental Medicine!

First 22 hours of zebrafish development. Credit to @zebrafish007.bsky.social at #WeinsteinLab. #ZebrafishZunday 🧪

Inspiring #DesignDay @mcgilluniversity.bsky.social! Proud of Giselle for her capstone presentation on improving islet-on-a-chip platforms to better model development & obtaining a BSc in Bioeng. The fabrication/3D printing wouldn’t be possible w/o collaboration w Juncker lab & @hoeslilab.bsky.social

Great work by @tigerhzjian.bsky.social

Congratulations to all the awardees of IRCM foundation scholarship, including our own Théa Milland & Noah Verreault. I appreciate the donors who made this possible. These awards are competitive & externally reviewed - I highly appreciate the reviewers for their time, effort and support of students!

Junior PI position in cancer research open at the IRCM. Apply below 👇🏽 #PIposition #assistantprofessor #cancer #openposition #ircm

Today in the 🇨🇦 National Grad course in #Islet Biology and #Diabetes we welcome superstars Cristina Nostro and @yassiag.bsky.social to discuss the latest on using #stemcell derived islet cells as a strategy to treat (cure?) #T1D!

Wrapping up a great year for the lab. We in 2025 we expanded and reached some important milestones as a growing team. Grateful for the collective effort and momentum. Wishing friends and colleagues a restful holiday season and a happy start to the new year.

Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪 #PancSky www.nature.com/articles/s41...

(3/3) SCN has supported this work every step of the way. From 2016–2028, SCN has committed over $11.5 million in funding for innovative diabetes research and clinical trials. ✨ Meet the SCN-funded researchers are helping pave the way.

(3/3) Le RCS a soutenu chaque étape de ces travaux, s’engageant à fournir plus de 11,5 M$ de 2016 à 2028 pour des recherches innovantes et des essais cliniques sur le diabète. ✨ Faites connaissance avec les chercheurs soutenus par le RCS qui contribuent à tracer le chemin dans ce domaine.

Proud PI moment at @RéseauThéCell: 🏅 Ying Deng – Best Poster PhD 🏅 Thea Milland – Best Poster MSc 🏅 Giselle de Leon – Best Poster BSc Representing @ircm.bsky.social , Ying and Thea @umontreal.ca , Giselle @mcgill.ca Grateful to organizers Kim Santerre and Dr Corinne Hoesli for this meeting!

It was great honor to attend and present at @navbo.bsky.social Vascular 2025 meeting. Huge thanks to the organizers for putting this tremendous meeting together. And what a special session focusing on vascularization of organoids and disease on a chip models.

📢 McGill University is hiring! The Department of Pharmacology and Therapeutics, with the Meakins-Christie Labs at the RI-MUHC, invites applications for a tenure-track Assistant Professor in Pluripotent Stem Cells in Regenerative Medicine. Learn more and apply. ➡️ stemcellnetwork.ca/wp-content/u...

Interesting and impactful new work by Estall lab: “Here, we identify a novel biological pathway downstream of glucagon that promotes the hepatic lipid accumulation associated with fasting” 👇🏽👇🏽👇🏽 #Glucagon #MASLD #Fasting

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health. 🔗 bit.ly/3HGWhX3

I’m one of the mentors for this year long internship :) Apply if you have interest in writing and Science Communication. There’s opportunity to get some of your pieces in DB @devbiol.bsky.social! Apply today!!

Very proud to share the first review from the lab with contributions of all lab members. Writing this gave our new lab opportunity to read and discuss many papers and grow as a team. www.frontiersin.org/journals/imm...

Very excited about our project aiming at advancing cell therapies for type 1 diabetes. and very thankful for receiving funding from @stemcellnetwork.ca

Preza et al. show that a circadian transcription factor specific to maturing stem cell-derived-β cells, DEC1, regulates insulin responsiveness to glucose. 🧪 #PancSky #StemCells www.biorxiv.org/content/10.1...

Stem cell-based models of early human development Read this Development at a Glance Article by Lizhong Liu @liliulab.bsky.social and Jun Wu @jun-wu-lab.bsky.social: journals.biologists.com/dev/article/...

Bonifacio and Ziegler summarize current evidence and guidance while emphasizing the need for continued research alongside broader screening application in #type1diabetes. 🧪 #PancSky dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, alleviates ER stress and reduces beta-cell immunogenicity www.cell.com/cell/fulltex...

Enterovirus infections may occur throughout the natural history of type 1 #diabetes and may be associated to islet cell HLA-I hyperexpression. @teresarc.bsky.social @sarahibex.bsky.social #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓

I've been really hoping someone would do a study like this! www.mcponline.org/article/S153...

Nice discussion on the usefulness of genetic and autoantibody screening in children for T1D

Happy Persian new year, Norouz, and the beginning of spring! 🌸🪻☀️

Today, rising stars @drprentice.bsky.social and @yassiag.bsky.social swing through the 🇨🇦 National #Islet and #Diabetes Course to discuss the latest on vascularizing stem cell-derived islet cells, adipose-islet communication, beta cell proliferation, and more @cirtn.bsky.social

Honored to have recieved this together with Dr Hoesli and @martinsauvageau.bsky.social

More cause to celebrate in this anti science climate! Happy international day of women and gender minorities in science 🧬

Read the latest Special Topic on Endothelial Cell and Pericyte Homeostasis and Pathogenesis in JHC: "Role of the Pancreatic Islet Microvasculature in Health and Disease." Click to read for FREE: bit.ly/4fihNMw #capillary #diabetes #endothelialcell

#RECRUITMENT | Shape Your Future in Biomedical Research At the IRCM, you can choose the program that best suits you and start your journey towards a rewarding career in research. The recruitment period runs from December 15, 2024, to January 31, 2025. www.ircm.qc.ca/en/studies #DrivenByLife

Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉 meetings.embo.org/event/25-liv...

Amidst the craziness in the world right now I feel there is even more reason to celebrate: Xuetao's paper is now online! Check it out : www.cell.com/stem-cell-re... 1/3

Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

This CityNews report highlights the expertise of Dr. Jane Yardley of the IRCM whose research focuses on physical activity in postmenopausal women living with type 1 diabetes. bit.ly/4fHOvXL

Important discussion in @devbiol.bsky.social by Scott Gilbert. As scientists, and as developmental biologists, we really need to share the facts we know with the public. #DevBio

#SciencePOP | Discover the 2024 winners in pictures Before a delighted audience, finalists of 12 institutions from all across Quebec gathered and competed in three high-level challenges. www.ircm.qc.ca/en/news-deta...

We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word! www.nature.com/naturecareer...

Check out our review led by the amazing @rlhull-meichle.bsky.social on the role of pancreatic microvascualture in health and disease and beta cell replacement therapies: journals.sagepub.com/doi/full/10....

We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!! www.imperial.ac.uk/jobs/search-...

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

On this #WorldDiabetesDay we took the opportunity to bring special attention to type ONE diabetes by #BlueBalloonChallenge, & to highlight the need for new therapies + exercise. Sneak peak below with @JaneYardley2 @Herve_VR @Olilideng @ircm_mtl @DiabetesCanada (full video tmrw)