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It is a really exciting time for #HPV #vaccines - @who.int also just approved a fourth HPV vaccine for single-dose use. Single dose regimens have the potential to help dramatically expand access globally.

"In 2023, 37 countries were implementing the single-dose schedule. As of 10 September 2024, 57 countries are implementing the single-dose schedule. WHO estimates that the single-dose schedule adoption has resulted in at least 6 million additional girls being reached with HPV vaccines in 2023."

#HPV #vaccines can play a huge role in mitigating health disparities in #cervicalcancer. "Every two minutes, a woman dies from this preventable disease globally, and 90% of these deaths occur in low- and middle-income countries. Of the 20 hardest hit countries by cervical cancer 19 are in Africa."

The JAMA article is a relatively simple ecological analysis of time series data (and rare events, too) - can't prove causality. But the rapid acceleration in decline of cervical cancer mortality - & timing in relation to #hpv #vaccine intro - is highly suggestive. #pedsIDsky #pedsky #IDsky

there are several studies with individual level data, all with encouraging results. Not sure if this is behind a paywall, if yes I will post the main figure from the publication. academic.oup.com/jnci/article...

Thanks! That article has a great overview of the history as well for anyone unfamiliar: #HPV #vaccines were licensed based on effectiveness against HPV infection and precancerous lesions (CIN) because the lag time between infection and cancer is so long. Some argued that this wasn't sufficient.