Aditya Krishna

Aditya Krishna

@adikrish.bsky.social

PhD student at Johns Hopkins Bat Lab | Hopkins Kavli NDI Distinguished Graduate Fellow| bats, hippocampus, superior colliculus

140 followers289 following10 posts

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Aditya Krishna reposted

Aditya Krishna reposted

How do 🐁deal with complex landscapes? Turns out they learn a lot very quickly. We think they do this by learning a set of repeated sparse paths, which form a type of compressed world model. Joint work with the Hermundstad lab, led by Tzuhsuan Ma and Alison Comrie: www.biorxiv.org/content/10.6...

Aditya Krishna reposted

Aditya Krishna reposted

Aditya Krishna reposted

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Aditya Krishna reposted

Today marks the 25th anniversary (😯) of our publication on discovery of FOXP2. To commemorate, I’ll repost a few prior threads about the gene. Here’s my explainer of how we tracked down FOXP2 & implicated it in speech/language deficits, in the days before completion of the human genome project.🗣️🧬🧪👇

Simon Fisher@profsimonfisher.bsky.social

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350.... A personal thread about the ups & downs of the journey we took to get to that point....1/n 🗣️🧬🧪

Aditya Krishna reposted

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

Aditya Krishna reposted

Aditya Krishna reposted

Aditya Krishna reposted

Now out in Hippocampus!! 📣💥 We examined anatomical inputs to the hippocampal region in six species - the tenrec, rat, marmoset, cat, macaque, and human - and found that hippocampal processing operates on fundamentally different types of information across species! (1/3) dx.doi.org/10.1002/hipo...

dx.doi.orgPhylogeny of Cortical‐Hippocampal Projections Reveals Selective Elimination of Input From Sensory RegionsThe study of cross-species differences in the organization of the cerebral cortex received significant attention during the past century. However, the evolutionary principles governing changes in bra...

Aditya Krishna reposted

Aditya Krishna reposted

I’m very excited to share our new paper, led by the very talented Jack Bowler, a postdoc in the lab! www.nature.com/articles/s41... We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N

nature.comStructured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex - Nature NeuroscienceThe authors use recurrent neural networks to predict how structured prior experience shapes neural dynamics as mice learn flexible timing strategies during complex context-dependent behavior.

Fantastic new work from Nikita Finger in the lab, investigating sensory conflict in Egyptian fruit bats by fitting them with prisms!!

jhubatlab.bsky.social@jhubatlab.bsky.social

What happens when a bat’s eyes and ears disagree? www.biorxiv.org/content/10.6... Dr. Nikita Finger Johns Hopkins University and Medical School

Aditya Krishna reposted

Aditya Krishna reposted

Our work on goal-directed theta sweeps is out! We found two different types of theta sweeps in the rat hippocampus. During random foraging, left-right alternating sweeps dominated (Vollan, 25). However, during memory-guided navigation sweeps pointing to hidden goal locations emerged with learning.

We highlight evidence that structures external to the canonical auditory pathway, such as the hippocampus, cerebellum, basal ganglia, and SC, play a critical role in shaping auditory processing during natural behavior.

We propose that auditory perception, especially under challenging listening conditions, is best understood as an emergent property of dynamic interactions between the canonical auditory pathway and cognitive networks.

Aditya Krishna reposted

New paper from Ulanovsky's group: With brain recordings from🦇 flying in a 200m tunnel, the group discovered that place cells of CA1 exhibit dense spatial coding, i.e., multiple place fields, and cells of CA3 exhibit ultrasparse coding, i.e., one place field. www.nature.com/articles/s41...

nature.comSparse-to-dense coding transformation between hippocampal areas CA3 and CA1 - NatureThe hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.

Aditya Krishna reposted

How does #vision shape spatial maps in the hippocampus? Check out our brand new preprint 👇 As someone who did a PhD on the #hippocampus & postdoc on visual cortex and superior colliculus, it's such a joy to start closing the loop - especially with such a great team! 😊

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Vision shapes neural maps of space through an ancient midbrain pathway https://www.biorxiv.org/content/10.64898/2026.05.16.725555v1

Aditya Krishna reposted

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

nature.comA synaptic locus of song learning - NatureCombining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapse...

Aditya Krishna reposted

Aditya Krishna reposted

Really excited to see this in print!

Cedric Boeckx@cedricboeckx.bsky.social

“Specific expansion of motor cortical projections in a singing mouse” Great new work by @arkarupbanerjee.bsky.social E. Isco @cliffscience.bsky.social @xmikezheng20.bsky.social @tonyzador.bsky.social & colleagues on the neural basis of vocal dexterity, now out in @nature.com 🧪🧠

Aditya Krishna reposted

Preprint alert! We've done the first ever wireless brain recordings from the high-level visual & motor regions (IT/PMv/PFC) in monkeys engaged in natural behaviors as well as during controlled screen-based tasks. Read below for a lay summary and the link for details! 1/8

Aditya Krishna reposted

Very excited to announce the first preprint from the lab @ucsantabarbara.bsky.social -- "Predictive pursuit emerges in high-dimensional RNNs." @wtredman.bsky.social (starting his own group at JHU this fall) summarizes the work nicely in this thread.

Will Redman@wtredman.bsky.social

New preprint out 🚨 “Predictive pursuit emerges in high-dimensional recurrent neural networks”! This was an awesome collaboration with co-first author @fatihdinc.bsky.social , @andyalexander.bsky.social, @xiaoxiao-lin.bsky.social, and May Chen biorxiv.org/content/10.6... 1/

Aditya Krishna reposted

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

Edvard I Moser@edvardmoser.bsky.social

Is spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats — before pups open eyes and ears and before they start upright walking. 🧵1:4 👇 www.biorxiv.org/content/10.6...

Aditya Krishna reposted

A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...

pnas.orgPlace cells in CA1 lack topographical organization of firing locations | PNASTopography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

Aditya Krishna reposted

New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP

Aditya Krishna reposted

The hippocampal map has its own attentional control signal! Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉 www.biorxiv.org/content/10.6... 🧵(1/6)

biorxiv.orgAttention-like regulation of theta sweeps in the brain's spatial navigation circuitSpatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

Aditya Krishna reposted

Where does learning through imitation happen in the brain? In juvenile zebra finches, we pinpoint a synaptic locus of song learning in a cortico-basal ganglia circuit and leverage this localization to measure the timescale of consolidation and make birds learn faster! #neuroskyence (1/14)

biorxiv.orgA synaptic locus of song learningLearning by imitation is the foundation for verbal and musical expression, but its underlying neural basis remains obscure. A juvenile male zebra finch imitates the multisyllabic song of an adult tutor in a process that depends on a song-specialized cortico-basal ganglia circuit, affording a powerful system to identify the synaptic substrates of imitative motor learning. Plasticity at a particular set of cortico-basal ganglia synapses is hypothesized to drive rapid learning-related changes in song before these changes are subsequently consolidated in downstream circuits. Nevertheless, this hypothesis is untested and the synaptic locus where learning initially occurs is unknown. By combining a computational framework to quantify song learning with synapse-specific optogenetic and chemogenetic manipulations within and directly downstream of the cortico-basal ganglia circuit, we identified the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning and characterized the hours-long timescale over which these changes consolidate. Furthermore, transiently augmenting postsynaptic activity in the basal ganglia briefly accelerates learning rates and persistently alters song, demonstrating a direct link between basal ganglia activity and rapid learning. These results localize the specific cortico-basal ganglia synapses that enable a juvenile songbird to learn to sing and reveal the circuit logic and behavioral timescales of this imitative learning paradigm. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, K99 NS144525 (DCS), F32 MH132152 (DCS), F31 HD098772 (SB), R01 NS099288 (RM), RF1 NS118424 (RM and JP)