Mohammed Khallaf

Mohammed Khallaf

@khallaf.bsky.social

Neuroscientist exploring sensory biology in naked mole-rats, mice, and flies. https://scholar.google.com/citations?user=ax7a1CwAAAAJ&hl=en

197 followers171 following82 posts

Each naked mole-rat has its own behavioral identity! The way it moves reveals who it is, its colony, and its social rank! Great work from @yukihaba.bsky.social

Ishmail Abdus-Saboor@ishmailsaboor.bsky.social

Excited to share my lab’s latest preprint led by postdoc @yukihaba.bsky.social and grad student Ryan Schwark. We surprisingly find that spontaneous behavior in isolation predicts a naked mole-rat’s identity, its colony membership, and even rank within its colony. www.biorxiv.org/content/10.6...

Mohammed Khallaf reposted

So grateful to @thetransmitter.bsky.social for the opportunity to talk about a paper that truly shaped how I think about my science by @fowleruci.bsky.social and @paulkennyphd.bsky.social! They helped make causal sense of the association that people call “Mr. Big“ in the context of 🚬!

The Transmitter @thetransmitter.bsky.social

In “This paper changed my life,” @drjkhokhar.bsky.social describes how a 2011 Nature study by Christie Fowler et al. set the standard for how to functionally validate genetic association study findings and was transformative for addiction neuroscience. www.thetransmitter.org/this-paper-c...

Mohammed Khallaf reposted

We're about to start an exciting new project with generous support from the @erc.europa.eu In SIMBIO, we want to know how bacterial endosymbionts modify neurons on the genetic and functional level and how this shapes the evolution of their host's mating behavior.

How do microbial symbionts shape neural circuits, mating behavior & evolution? With the new #ERC-funded project SIMBIO, Philipp Brand @pbrand.bsky.social and his team @mpibrain.bsky.social will explore how microbes shape brains and behavior. #ERCStG 🔗 brain.mpg.de/brand-erc-st...

Mohammed Khallaf reposted

For too long, we have only had 2 sex-specifically spliced genes in the mosquito. Welcome to the world, MOSN! Males: big protein. Females: small protein. Fascinating new domain of unknown function. Congrats Yael Tsitohay + Nipun Basrur. Collab with Sean Eddy + Li Zhao www.biorxiv.org/content/10.6...

biorxiv.orgEvolution of MOSN, a novel sex-specifically spliced neuronal gene in the Aedes aegypti mosquitoSex-specific RNA splicing is a conserved mechanism for generating sexual dimorphism in insects, with the best-studied examples being fruitless and doublesex. To ask whether additional sex-specifically...

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Join us in Oldenburg and study the #SensoryBasis 👀👂👃🤚👅🧭, Mechanisms 🧠🧬🧪, and Impacts of #AnimalNavigation in our Cluster of Excellence "NaviSense" as a PhD student 🎓 👇 In case you would like to discuss project ideas related to #insect #navigation, feel free to contact me 🤗 🐜❤️ #NaviSense #CoE #ExStra

SFB 1372@sfb1372.bsky.social

NaviSense, the Cluster of Excellence on Animal Navigation at the University of Oldenburg, is looking for motivated doctoral researchers to join their interdisciplinary team! Find more details here: 🔗 uol.de/job1191en #DoctoralResearcher #AnimalNavigation #Oldenburg

Mohammed Khallaf reposted

Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!

cell.comThe sex and reproductive plasticity of intestinal muscles instruct gut sizeAdult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

“I believe my findings are just the tip of a bigger iceberg.” Read more about the work from Alessandro, a postdoc in our Organ Development and Physiology Lab led by @irenemiguel-aliaga.bsky.social, who studied changes in the female intestine during and after reproduction: https://bit.ly/4bElX2u

Mohammed Khallaf reposted

We’re recruiting postdocs! Join our @wellcometrust.bsky.social funded programme 'Decoding competition in the brain'. How does the brain resolve competing needs and prioritise behaviour? 📅 Deadline: 1 September Apply: rezavallab.org Please share! www.jobs.ac.uk/job/DSM781/r...

jobs.ac.ukResearch Fellow (Postdoctoral) at University of BirminghamRecruiting now: Research Fellow (Postdoctoral) on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board
uobles.bsky.social@uobles.bsky.social

Professor Carolina Rezaval has been awarded a Wellcome Discovery Award for £2.9 million to investigate how the brain makes decisions under competition. www.birmingham.ac.uk/news/2026/2....

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Finally got my Canadian visa sorted (the joys of being a non-EU traveler 😅), so I’m flying out this weekend for the NeuroEthology congress! I’ll be presenting a poster on courtship behaviour and vocalisation in naked mole-rats. If anyone wants to catch up or meet for the first time, let’s chat!

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Beautiful work on the evolution of sensory perception. Existing neuronal lineages are often recoded throughout evolution by the expression of novel olfactory receptor genes. The Arguello lab reconstructed all the steps in this sensory neuron recoding. A must-read!

tomtom-auer.bsky.social@tomtom-auer.bsky.social

How do duplicated receptor genes "find a home" in olfactory circuits? Great study by the Arguello lab shows the re-coding of olfactory channels across species. Neat combination of phylogenetic reconstruction, sc-transcriptomics and more. Check out the pre-print: www.biorxiv.org/content/10.6...

Mohammed Khallaf reposted

How do duplicated receptor genes "find a home" in olfactory circuits? Great study by the Arguello lab shows the re-coding of olfactory channels across species. Neat combination of phylogenetic reconstruction, sc-transcriptomics and more. Check out the pre-print: www.biorxiv.org/content/10.6...

biorxiv.orgEvolutionary Recoding of Olfactory Sensory NeuronsOdorant receptors ( Or s) are the interface between an animal’s nervous system and its olfactory environment. In insect genomes, the Or s are often the largest gene family, and their rapid duplication...

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Excited to have this #PainResearch paper out from our @phar.cam.ac.uk lab: "Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease" journals.lww.com/painrpts/ful...

journals.lww.comMonoclonal antibody inhibition of PAR2 reduces phenotype... : PAIN Reportsmising therapeutic target for visceral pain management in IBD. Objectives: We set out to determine signaling mechanisms deployed by PAR2 in the lumbar splanchnic nerve and whether inhibiting PAR2 with the mouse monoclonal antibody (mAb), PAR650097 (mPAR650097) provided therapeutic benefit in dextran sulfate sodium (DSS)-induced colitis. Methods: We first used ex vivo electrophysiological recordings of mouse lumbar splanchnic nerve to determine how stimulation of PAR2 alters afferent activity and the intracellular signaling mechanisms involved. Second, we used the DSS model of colitis in mice and determined how mPAR650097 altered disease activity, behavior, colon histology, and the activity of nociceptive circuitry. Results: Protease-activated receptor 2 stimulation in the colon activated visceral afferent fibers and sensitized them to mechanical and chemical stimuli. We found that endosomal internalization and protein kinase A/C signaling mediate both activating and sensitizing effects of PAR2 in visceral pain. We further show that inhibiting PAR2 with the mAb mPAR650097 reduces DSS-induced colitis severity and pain. mPAR650097 also reduced several colitis-induced pain correlates at key points along the pain-signaling axis, including peripheral nociceptive neuron signaling and sensitivity, expression of proinflammatory mediators, spinal cord signaling, and, fundamentally, behavior. Conclusion: These findings illustrate that mAb inhibition of PAR2 represents a promising approach to provide relief from abdominal pain in those living with IBD....

Mohammed Khallaf reposted

And another great paper in Cell from the best ever behavioralist, Dr. Shimaa Ebrahim!!!

shimaaebrahim.bsky.social@shimaaebrahim.bsky.social

nam12.safelinks.protection.outlook.com?url=https%3A... I’m thrilled to share my journey from the kitchen to the lab, which has ultimately led me to publish in Cell Journals. I hope you enjoy reading my latest paper:

Mohammed Khallaf reposted

🎉New paper out from the lab, led by @baptistepiqueret.bsky.social: ant larvae chemically suppress the reproduction of their caregivers. bit.ly/4t8uZLG An example of how social interactions are regulated at the molecular level. The work was made possible by the unique environment @mpi-ce.bsky.social

pnas.orgpnas.org

A research team from @yukoulrich.bsky.social‘s lab at our institute has identified the first brood pheromone in ants—thereby proving that larvae of clonal raider ants actively influence the colony’s reproduction cycle. www.ice.mpg.de/550783/PR_Pi...

Mohammed Khallaf reposted

New Review 👇 The molecular evolution of vertebrate organs: www.nature.com/articles/s41... Margarida Cardoso-Moreira discusses rates of evolution of organs and cell types, molecular mechanisms of organ evolution and how complex traits contributed to the diversification of vertebrates.

nature.comThe molecular evolution of vertebrate organs - Nature Ecology & EvolutionThis Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms of organ evolution and how complex tr...

Mohammed Khallaf reposted

🗞️Our March issue is live, with killifish artwork by Dario Valenzano on the cover!🎨Read work on senescence in mammary gland remodelling, structural protein changes as readouts of Alzheimer’s disease, the 201 Parkinson’s disease trial & more ✨https://nature.com/nataging/volumes/6/issues/3

Mohammed Khallaf reposted

We are very proud: Julio Antonio Otárola Jiménez successfully defended his PhD thesis today! His research topic was "From Courtship to Egg-Laying: How Chemical Cues and Experience Shape Reproductive Strategies in Drosophila melanogaster". Congratulations, Julio!

Mohammed Khallaf reposted

Why is Spotted Wing Drosophila attracted to fruit at its prime, instead of overripe fruit like other flies? Xue and Dweck found the neuron receptor shifts responsible for this $500M agricultural problem, in this impressive 2-author work out of the CT Ag Experiment Station!

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Mohammed Khallaf reposted

Mohammed Khallaf reposted