Ali D. Güler

bsky.app/profile/did:...

The dorsal vagal complex is a satiety center in the brainstem that exhibits rhythmic activity independent of the brain's main clock. This study examines the factors that entraining DVC oscillations, revealing that these #circadian rhythms are entrained by meal timing. 🧪 #AcademicSky plos.io/4xqnlhB

Our CeA GLP-1 story is now online. We've got a lot more cooking in this area and I think this will inform future circuit-guided GLP-1 therapeutics: www.sciencedirect.com/science/arti... Great job to my first PhD student, Miguel Duran, who has had a hell of a week.

Here's the article. diabetesjournals.org/care/article...

Now in peer-reviewed form: www.nature.com/articles/s41...

Awesome work by @aguler.bsky.social and team providing critical new insights into the mechanisms of next-gen (small molecule) GLP-1R agonists!!!! Turns out the CeA is important :) www.nature.com/articles/s41...

Congratulations! Exciting work; it seems like CeA is critical for hedonic food consumption, who would have guessed 😉

Chemogenetic inhibition of CeA GLP-1R neurons resulted in a strong rescue of Ex-4-mediated reductions in high fat diet intake using a hedonic intermittent access paradigm. This suggests that this cell type is playing a pivotal role in the neural circuitry mediating reductions in appetite by GLP-1s.

But what about the target of these drugs? Those that express the GLP-1 receptor. Turns out the CeA has many cells that express GLP-1R, enriched in the medial portion. Our initial characterization here: pubmed.ncbi.nlm.nih.gov/35002645/

But is this just an association or is there a causal relationship? Here's where we used inhibitory chemogenetics combined with an army of FED3s (hat tip @kravitzlab.com) to assess whether activation of the CeA was required for the hypophagic actions of Ex4.

Really thrilled to share my lab's latest work where we characterize the role of the CeA in integrating exogenous GLP-1 signals. www.biorxiv.org/content/10.6...

Terns is developing drugs for cancer and weight loss. Its lead candidate is TERN-701, a small molecule designed to treat chronic myeloid leukemia. #chemsky 🧪

🧠 BREAKTHROUGH: UMSOM researchers at @genomescience.bsky.social created NeMO Analytics, a massive multi‑omic database combining data from 188 studies — revealing new insights into how the neocortex develops across species. 📰 More: bit.ly/4uPvLP3 #Neuroscience #BICAN #BrainResearch #Medsky #MedEd

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again. #Pinks #ProudBlue

This is amazing 👇

Dosing on the way down improves outcomes for glioblastoma. Thanks Maddy Frank for covering this collaboration with @oliviawalch.bsky.social and WashU grad student @mariafelicita.bsky.social. #chronotherapy #circadian #medicine source.washu.edu/2025/11/timi...

Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events. Deafening Quiet from the Scientific Establishment jeremymberg.github.io/jeremyberg.g... 1/14

Interested in a tenure track position teaching and doing research with undergrads at a PUI? We are looking for a broadly-defined microbiologist who can teach Med Micro and Immunology. Apply at universityofscrantonjobs.com/postings/8308. Pls share widely to feeds (& on twitter if you still tweet)! 🦠

I am not a political pawn. I am a living, breathing human being who has dedicated her life to a scientific problem that I believe matters for human health. The article below tells our story; I hope you will read it and share it www.nytimes.com/2025/09/14/m...

Don't miss this opportunity to be our colleague! Very exciting initiative here at UVA!

Come be my colleague! Happy to answer any questions about what it's like living in Charlottesville and being in the department.

We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄 Apply today & help shape the future of neuroscience: 👉 apply.interfolio.com/172892

🚨 We’re hiring! 🧪 @uvabio.bsky.social UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠 Apply by Oct 15, 2025. Start Aug 2026. 👉 apply.interfolio.com/172892 #Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits https://www.biorxiv.org/content/10.1101/2025.08.12.669936v1

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...

My team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here: research.jhu.edu/rdt/funding-... For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc. Good luck!

It doesn't matter if the Executive Order is illegal. The NIH has demonstrated consistently that it will follow orders from the OMB. Expect immediate action from the NIH on this order. As I told you months ago, the old NIH is gone.

www.nytimes.com/2025/08/07/h...

People who were overweight or had obesity lost a substantial amount of weight after taking a daily pill made by Eli Lilly, the company reported Wednesday. If the pill is approved by the FDA, it'll provide an alternative to weight-loss injectables like Ozempic.

"What struck me was that many of my colleagues at universities [last week] were like, ‘Oh, my God, they’re stopping grants!’ And it seemed to activate people in a way that I hadn’t seen before. Whereas a lot of us at NIH thought, ‘Oh, they just did another thing [to stop grants].’” 🧪

#JNeurosci: Stritzel et al. found that brief nighttime exposure to dim red light conditions widely used in rodent research caused circadian disruption and red light stimuli were detected by the rodent visual system. ‪@colorado.edu‬ @vulintus.com‬ https://doi.org/10.1523/JNEUROSCI.0157-25.2025

If they really had our backs, they would take steps RIGHT NOW to stop the NIH from continuing with the multi year mandate pushed by Vought and the OMB.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

Houston researchers found that low-dose metformin needs Rap1 in the brain to lower blood sugar. Without brain Rap1, metformin doesn’t work, but other diabetes drugs still do. The ventromedial hypothalamus is the key control site. www.science.org/doi/10.1126/...

Blame the damn human not the poor mouse! open.substack.com/pub/zendudes...

Here's the provision to block multi-year funding: (the bill text PDF will later be updated with this as an adopted amendment: www.appropriations.senate.gov/imo/media/do...)

The bill is not posted but multiple sources tell me that it contains a provision that multi-year funding cannot exceed fiscal year 2024 levels. I will check as soon as it is posted.